Searchable abstracts of presentations at key conferences in endocrinology

ea0063ep2 | Adrenal and Neuroendocrine Tumours | ECE2019

Congenital adrenal hyperplasia (salt wasting form) with central precocious puberty: A combined therapeutic approach using a nighttime glucocorticoid dose, an aromatase inhibitor and a gonadotropin-releasing hormone analogue

Barbacariu Ioana-Cristina , Cristea Cristina , Dragoman Paula-Maria , Pavăl Cristina Victoria , Siriteanu Andreea-Mariana , Cretu Cristina , Preda Cristina

Congenital adrenal hyperplasia (CAH) describes a group of autosomal recessive disorders where the cortisol biosynthesis is impaired. There are two forms of CAH: the classic form, which includes the salt-wasting and the simple virilizing forms, and the nonclassic form. CAH due to 21-hydroxylase deficiency accounts for 95% of cases. Treatment of the classic form of CAH is targeted at replacing cortisol and aldosterone and effectively controlling excess androgen symptoms by using...

ea0022p860 | Thyroid | ECE2010

Thyroid incidentaloma: palpable problems of an impalpable nodule

Vulpoi Carmen , Mogos Voichita , Ciobanu Delia , Preda Cristina , Cristea Cristina , Ungureanu Maria-Christina , Leustean Letitia , Zbranca Eusebie

The widespread of sensitive imaging methods have substantially increased the incidental finding of subclinical thyroid nodules. The ‘epidemic’ of thyroid incidentaloma has raised numerous discussions regarding their management: Is it necessary to investigate all nodules or is surveillance sufficient? Which criteria should be used in order to identify the nodules which must be investigated by fine-needle aspiration (FNA) (size, echogenicity, vascularisation)? Should w...

ea0081ep1045 | Thyroid | ECE2022

Metachronous renal cell carcinoma metastasis to the thyroid

Cretu Cristina , Cristea Cristina , Barbacariu Ioana- Cristina , Dragoman Paula , Livenschi Lucia Flavia , Florescu Diana Nicoleta , Danila Radu , Ciobanu Delia , Preda Cristina

Introduction: Metastatic disease into the thyroid is a rare event, despite the gland’s rich vascular supply. Renal cell carcinoma (RCC) is an unusual neoplasm that not only has the potential to recur after a latent disease-free interval, but also has the potential to metastasize to rare sites like the thyroid. However, of the clinically significant secondary neoplasms of the thyroid, metastatic RCC is the culprit in most cases. Case report: We prese...

ea0014p504 | (1) | ECE2007

Unusual onset of Graves’ disease – case report

Cristea Cristina , Ciornohuz Adriana , Zbranca Eusebie

Graves’ thyrotoxicosis frequently occurs after delivery through immune rebound mechanism. A 34 years old patient, in postpartum period was referred to rheumatologist for gradually gait impairment. Examination showed only weakness of pelvic girdle muscles which required an extensive differential diagnosis including: neurological diseases and inflammatory/metabolic/toxic myopathies. Routine lab tests were unremarkable except low cholesterol (128 mg/dl) and slightly increase...

ea0014p591 | (1) | ECE2007

Self-concept in patients with PCOS

Gotca Ioan , Cristea Cristina , Leustean Letitia , Ioana Draghici , Zbranca Eusebie

Polycystic ovary syndrome (PCOS) is a major source of psychological morbidity and can negatively affect quality of life. The aim of the study was to identify characteristics of self-concept in female patients diagnosed with PCOS (n=22, mean age 26+/− 11 years) and comparative analysis with a control group (n=22).Methods: Psychology questionnaire, selection tests based on geometrical figures/ words and also graph logical analysis were ...

ea0099ep90 | Adrenal and Cardiovascular Endocrinology | ECE2024

Familial glucocorticoid deficiency type 2 – a case report

Chelaru Nicoleta , Cretu Cristina , Cabac Mariana , Cristea Cristina

Background: Mutations in the ACTH receptor (MC2R) gene or in its melanocortin accessory protein (MRAP) gene disrupt receptor expression, signaling, and constitutive activity of the MC2R, leading to familial glucocorticoid deficiency (FGD) type 1 and type 2 respectively. FGD is a life-threatening, rare autosomal recessive disorder characterized by impaired cortisol synthesis and classically preserved mineralocorticoid production. There have also been described other mutations t...

ea0032p607 | Female reproduction | ECE2013

Main determinants of serum uric acid concentrations in polycystic ovary syndrome patients

Leustean Letitia , Preda Cristina , Ungureanu Maria Christina , Cristea Cristina , Mogos Voichita , Ungureanu Didona , Vulpoi Carmen

Introduction: Uric acid may increase cardiovascular risk, exerting proinflammatory, pro-oxidant and proliferative actions at the endothelial cell level. Classic and non-classic cardiovascular risk markers cluster in women with polycystic ovary syndrome (PCOS), uric acid being proposed as one of them. The studies available at present regarding serum uric acid levels in PCOS patients are scarce and controversial. The aim of the study was to examine the relationship between uric ...

ea0014p180 | (1) | ECE2007

Lower catch-up growth under rGH therapy at pre-pubertal pituitary dwarves diagnosed at an older age

Branisteanu Dumitru , Galesanu Corina , Cristea Cristina , Zbranca Eusebie , Vulpoi Carmen , Preda Cristina , Mogos Voichita

Growth hormone deficiency leads to profoundly decreased growth velocity and, when untreated, to pituitary dwarfism. We evaluated growth evolution for one to four years under rGH therapy (0.07 IU/kg/day, subcutaneously) at seventeen idiopathic pituitary dwarves with isolated GH deficiency, 13 boys and 4 girls, with a wide span of age at therapy onset (between 4 and 24 years old). Diagnosis was set subsequent to at least two negative GH stimulation tests. All patients were pre-p...

ea0014p470 | (1) | ECE2007

Thyrotoxic hypokalemic periodic paralysis in two Caucasian females

Preda Cristina , Leustean Letitia , Vulpoi Carmen , Cristea Cristina , Ungureanu Christina , Zbranca Eusebie

Hypokalemic periodic paralysis is an uncommon complication of thyrotoxicosis especially in Caucasian women. It is most frequent in east asian and Japanese males and is characterized by recurrent episodes of motor weekness of variable intensity associated with hyperthyroidism. It is usually associated with low plasma potassium levels and is often precipitated by physical activity. This condition is a self limiting disorder that is cured by the treatment of the underlying hypert...

ea0063ep14 | Adrenal and Neuroendocrine Tumours | ECE2019

The diagnosis of Cushing’s syndrome in pulmonary adenocarcinoma associated with an unilateral adrenal mass - case report

Paval Cristina Victoria , Cristea Cristina , Siriteanu Andreea-Mariana , Barbacariu Ioana-Cristina , Dragoman Paula Maria , Cretu Cristina , Preda Cristina

Cushing’s syndrome is a collection of signs and symptoms due to prolonged exposure to cortisol. It can be difficult to diagnose, particularly endogenous Cushing’s syndrome, because other conditions share the same signs and symptoms. Diagnosing Cushing’s syndrome can be a long and extensive process, it’s treatment may be also an important challenge. We present the case of a 49-year-old man, with a history of asthma and pulmonary cribriform adenocarcinoma (ra...