Searchable abstracts of presentations at key conferences in endocrinology

ea0086hdi1.5 | How do I...? 1 | SFEBES2022

How do I monitor a patient on mitotane?

Ronchi Cristina

Adrenocortical carcinoma (ACC) is a rare endocrine tumour with a generally poor prognosis. Mitotane is the only approved drug for treatment of advanced ACC (“palliative” setting). However, response is relatively poor with up to 20% of patients experiencing objective response (Megerle 2018). Moreover, adjuvant treatment with mitotane is frequently recommended for patients at high risk of disease recurrence after surgery (Terzolo 2007, Fassnacht 2018). Of note, mitotan...

ea0070ep324 | Pituitary and Neuroendocrinology | ECE2020

Significant weight loss as an unusual presentation of empty sella – case report

Ene Cristina

Introduction: Unexplained weight loss is a cause for concern; it might indicate an underlying condition, usualy a catabolic state. In empty sella, the progressive loss of pituitary hormone secretion is usually a slow process, with symptoms varying from one person to another and depends on the underlying cause. Usually the weight remain relatively constant or we could have several arguments for weight gain.Case report: A 57 years old man with significant ...

ea0099ep782 | Calcium and Bone | ECE2024

Klinefelter Syndrome and Primary hyperparathyroidism—just a coincidence?

Ene Cristina

Background: Two prevalent and underdiagnosed endocrine disorders are primary hyperparathyroidism and Klinefelter syndrome. The main cause of primary hyperparathyroidism is parathyroid adenoma. Less commonly multiple parathyroid hyperplasia have been described with or without genetic mutations. Klinefelter syndrome could also be seen as a genetic disorder, being a chromosomal condition. Methods: We report an uncommon association, without any family histor...

ea0099ep7 | Thyroid | ECE2024

Recurrent subacute thyroiditis - a genetic disease or a still not well-undestood one?

Ene Cristina

Background: Subacute thyroiditis is considered a rare form of inflammatory thyroid disease, triggered by a viral infection. The prevalence is higher in women and in the middle-aged groups. The rate of subacute thyroiditis recurrence is between 1.4% and 20%, with wide discrepancies between different studies; the relapse may occur soon after de treatment or even years after, and recent studies show an HLA-dependence.Methods: We present a case report of rec...

ea0077s6.1 | Characterising the cortex to improve clinical care | SFEBES2021

Characterizing the Cortex to Improve Clinical Care. Single cell sequencing: lessons for the pathogenesis of adrenocortical tumours

Ronchi Cristina L

Key learning points• Adrenocortical tumors comprise frequent benign adenomas and rare aggressive carcinomas (ACC).• cAMP/PKA pathway plays a central role in the pathogenesis of cortisol-producing adenomas - associated with Cushing syndrome, while molecular alterations in Wnt/β-catenin, Rb/p53 pathway and chromatin remodeling are frequent in ACCs.<p class="a...

ea0086bpw2.1 | New advances in neuroendocrinology | SFEBES2022

How does the brain know what you’ve eaten?

Garcia-Caceres Cristina

The underlying basis for understanding of how brain control energy homeostasis, resides in a functional and coordinate communicating pathways between peripheral endocrine organs and the brain, in which the hypothalamus plays a pivotal role in the integration and processing of peripheral metabolic cues into satiety and feeding signals. Glial cells in particular astrocytes, as being an integral cell type of the neurovascular unit forming direct physical contacts with cerebral b...

ea0066p85 | Thyroid | BSPED2019

Paediatric Graves disease – management in a District General Hospital

Viswanath Vidya , Matei Cristina

Background: Graves disease is the most common cause of hyperthyroidism or thyrotoxicosis in children. The prevalance is 1 in 10 000 among children. It is important to reinforce the awareness amongst clinicians as patients can present with wide range of clinical symptoms. The range of presentations in our study included a child treated for one year for Attention Deficit Hyperactivity Disorder (ADHD) to a child who had diarrhoea and abdominal pain and presented as appendicitis i...

ea0063p1218 | Thyroid 3 | ECE2019

Association of polycystic ovary syndrome and graves’ disease – case report

Radu Cristina Corina Pop

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, only a few cases indicating association between PCOS and Graves’ disease are reported.Case report: We present a woman aged 29 with Graves' disease certified by suppressed TSH (0.001 mUI/l), high FT4 (6.6 ng/dl) associated with elevated TRAb (...

ea0063ep111 | Pituitary and Neuroendocrinology | ECE2019

A case of primary autoimmune hypophysitis associated with hashimoto’s disease, alopecia areata and chronic hepatitis

Pop-Radu Cristina Corina

Background: Primary autoimmune hypophysitis (PAH) is a rare chronic inflammatory condition of the pituitary gland that occurs more commonly in females during pregnancy or in the post-partum period. It is strongly associated with other autoimmune disorders. The various forms of hypophysitis are misdiagnosed as pituitary adenoma in 40% cases.Objective: First of all, we propose to present a case of PAH associated with other autoimmune diseases. Our second a...

ea0049ep241 | Bone &amp; Osteoporosis | ECE2017

Normocalcemic primary hyperparathyroidism (NPH)

Pop-Radu Cristina Corina

Normocalcemic primary hyperparathyroidism (NPH) is characterized by normal total and ionized serum calcium concentrations and consistently elevated PTH levels. These patients have no obvious causes for secondary elevations of PTH, such as renal disease, vitamin D deficiency or malnutrition. The group consisted of 22 postmenopausal women, six premenopausal women, and two men, aged 58±2 years (range 31–77) investigated between 2011 and 2016.Resul...