Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep152 | Calcium and Vitamin D metabolism | ECE2016

Calcium as a marker of metabolic decompensation in glycogen storage disease type-1a

Sendur Suleyman Nahit , Unluturk Ugur , Dagdelen Selcuk

Introduction: Glycogen storage disease type 1a (GSD1a) is an inborn error of metabolism with several metabolic decompensations including anaerobic glycolysis and lactic acidosis but few known about GSD1a-related hypercalcemia. Here we aimed to present a putative relationship between serum Ca and the affected metabolic parameters during metabolic decompensation of GSD1a.Case report: Two patients with GSD1a and hypercalcemia were retrospectively analyzed. ...

ea0032p900 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Increased thyroid cancer risk in acromegaly

Dagdelen Selcuk , Cinar Nese , Erbas Tomris

Introduction: Generously supported by IPSEN)-->Acromegaly increases cancer risk. We aimed to determine the prevalence and the predictors of tumors in acromegalic patients treated at our department.Design: We retrospectively evaluated 142 acromegalic patients (75 females (mean age 52.1±10.4 years and 67 males (mean age 49.4±12.7 years)) treated at university center, endocrinology outpatient clinic betw...

ea0022oc2.5 | Thyroid | ECE2010

Thyroid dysfunction related abnormalities in adiponectin and glucose metabolism before and after treatment

Ozdemir Didem , Dagdelen Selcuk , Usman Aydan

Objective: Thyroid dysfunctions have various effects on glucose and lipid metabolism. Adiponectin (ADP) is an adipokine decreased in obesity and insulin resistance. In this study, we aimed to investigate the role for ADP in thyroid dysfunction related changes in glucose and lipid metabolism.Methods: Newly diagnosed overt hypothyroid (n=20) and thyrotoxic (n=23) adult patients with a body mass index (BMI)<30 kg/m2 were include...

ea0041gp67 | Clinical Case Reports | ECE2016

Nivolumab associated thyroiditis in a patient with squamous non small cell lung cancer

Sendur Ayse , Sendur Suleyman Nahit , Demirkazik Ahmet , Dagdelen Selcuk , Erbas Tomris

Nivolumab is the first programmed death 1 (PD-1) immune checkpoint inhibitor. It is approved for use in advanced melanoma and squamous non small cell lung cancer (NSCLC). PD-1 immune checkpoint inhibitors can cause autoimmune disease of endocrine glands, including the thyroid. Here, we present a case of thyroiditis after nivolumab therapy.A 61 year-old female patient with NSCLC was consulted to endocrinology department for abnormal thyroid function test ...

ea0041gp83 | Diabetes (1) | ECE2016

Does IGF2BP2 gene polymorphism have an effect on the development of gestational diabetes mellitus?

Ilke Cikman Duygu , Seyhan Cikman Muzaffer , Ali Kasifoglu Mehmet , Dagdelen Selcuk

Objective: Gestational diabetes mellitus (GDM) is a multifactorial disorder with environmental factors and genetic modifiers. IGF2BP2 gene polymorphisms are shown to be involved in T2DM and diabetic nephropathy. Here, we aimed to document the association between IGF2BP2 gene polymorphism and GDM to understand the pathogenesis of GDM.Design: Matched, case-control study.Method: Ninety-three patients with GDM and 89 healthy pregnant s...

ea0035p48 | Adrenal cortex | ECE2014

Retrospective analysis of adrenal ıncidentalomas: a single center experience

Akin Safak , Helvaci Nafiye , Dagdelen Selcuk , Yildiz Bulent Okan , Gurlek Alper , Erbas Tomris , Bayraktar Miyase

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

ea0035p388 | Diabetes (epidemiology, pathophysiology) | ECE2014

What is the contribution of MODY gene polymorphisms in the development of gestational diabetes mellitus?

Cikman Duygu Ilke , Cikman Muzaffer Seyhan , Erbas Tomris , Alikasifoglu Mehmet , Dagdelen Selcuk

Objective: Gestational diabetes mellitus (GDM) is the consequence of increased insulin resistance during pregnancy in predisposed individuals who already have impaired insulin secretion due to beta-cell dysfunction as in maturity onset diabetes of young (MODY) cases. Here we aimed to document the association between MODY subtypes and GDM to understand the pathogenesis of GD.Design: Matched, case-control study.Method: Ninety-three p...

ea0070aep1072 | Hot topics (including COVID-19) | ECE2020

Pregnancy outcomes in acromegaly: A single tertiary center case series

Gonul Iremli Burcin , Hanife Oguz Seda , Firlatan Busra , Dagdelen Selcuk , Erbas Tomris

Introduction: Pregnancy occurs relatively rare women with acromegaly. However, in recent years, pregnancy has become more likely to occur in acromegalic women possibly due to improvements in acromegaly treatment, and advanced assisted reproduction techniques.Methods: In this case series, we retrospectively analyzed 11 pregnancies of 8 acromegalic women followed in the university hospital in a time range between 2009–2019. Data were obtained from pa...

ea0032p62 | Adrenal cortex | ECE2013

Metastatic adrenocortical carcinoma presenting with concomitant secretion of glucocorticoid, mineralocorticoid, androgen, and catecholamines: a case report

Akin Safak , Dagdelen Selcuk , Yuksel Elif , Altindag Kadri , Sayek Iskender , Baydar Dilek Ertoy , Erbas Tomris

Introduction: We report the first case of metastatic adrenocortical carcinoma (ACC) concomitantly secreting cortisol, aldosterone, catecholamines and androgens with the extensive distant metastasis at the time of diagnosis.Case report: A 57-year-old woman referred for left adrenal mass (5.5×4.0 cm) two years after the diagnosis of breast cancer. The patient’s medical history revealed hypertension and diabetes mellitus. She has cushingoid and hy...

ea0035p442 | Diabetes complications | ECE2014

Dental care and periodontal disease in Turkish diabetic patients

Kaya Selin Kucukyurt , Sahin Demet , Askin Sezen Buyukozdemir , Ilhan Ayse , Erdal Sevgi , Dagdelen Selcuk , Nohutcu Rahime M , Erbas Tomris

Diabetes mellitus is a common and growing global health problem leading to several complications. Among these, periodontal diseases are considered as the sixth complication of diabetes. The goals of this cross-sectional study were to assess Turkish diabetic patients’ oral health behaviors and association with demographic characteristics, access to dental care and need for improved health education. The study sample consisted of 121 diabetic patients (43 M/78 F), with a me...