Endocrine Abstracts

Introduction: Glycogen storage disease type 1a (GSD1a) is an inborn error of metabolism with several metabolic decompensations including anaerobic glycolysis and lactic acidosis but few known about GSD1a-related hypercalcemia. Here we aimed to present a putative relationship between serum Ca and the affected metabolic parameters during metabolic decompensation of GSD1a.Case report: Two patients with GSD1a and hypercalcemia were retrospectively analyzed. ...

Introduction: Generously supported by IPSEN)-->Acromegaly increases cancer risk. We aimed to determine the prevalence and the predictors of tumors in acromegalic patients treated at our department.Design: We retrospectively evaluated 142 acromegalic patients (75 females (mean age 52.1±10.4 years and 67 males (mean age 49.4±12.7 years)) treated at university center, endocrinology outpatient clinic betw...

Objective: Thyroid dysfunctions have various effects on glucose and lipid metabolism. Adiponectin (ADP) is an adipokine decreased in obesity and insulin resistance. In this study, we aimed to investigate the role for ADP in thyroid dysfunction related changes in glucose and lipid metabolism.Methods: Newly diagnosed overt hypothyroid (n=20) and thyrotoxic (n=23) adult patients with a body mass index (BMI)<30 kg/m2 were include...

Nivolumab is the first programmed death 1 (PD-1) immune checkpoint inhibitor. It is approved for use in advanced melanoma and squamous non small cell lung cancer (NSCLC). PD-1 immune checkpoint inhibitors can cause autoimmune disease of endocrine glands, including the thyroid. Here, we present a case of thyroiditis after nivolumab therapy.A 61 year-old female patient with NSCLC was consulted to endocrinology department for abnormal thyroid function test ...

Objective: Gestational diabetes mellitus (GDM) is a multifactorial disorder with environmental factors and genetic modifiers. IGF2BP2 gene polymorphisms are shown to be involved in T2DM and diabetic nephropathy. Here, we aimed to document the association between IGF2BP2 gene polymorphism and GDM to understand the pathogenesis of GDM.Design: Matched, case-control study.Method: Ninety-three patients with GDM and 89 healthy pregnant s...

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

Objective: Gestational diabetes mellitus (GDM) is the consequence of increased insulin resistance during pregnancy in predisposed individuals who already have impaired insulin secretion due to beta-cell dysfunction as in maturity onset diabetes of young (MODY) cases. Here we aimed to document the association between MODY subtypes and GDM to understand the pathogenesis of GD.Design: Matched, case-control study.Method: Ninety-three p...

Introduction: Pregnancy occurs relatively rare women with acromegaly. However, in recent years, pregnancy has become more likely to occur in acromegalic women possibly due to improvements in acromegaly treatment, and advanced assisted reproduction techniques.Methods: In this case series, we retrospectively analyzed 11 pregnancies of 8 acromegalic women followed in the university hospital in a time range between 2009–2019. Data were obtained from pa...

Introduction: We report the first case of metastatic adrenocortical carcinoma (ACC) concomitantly secreting cortisol, aldosterone, catecholamines and androgens with the extensive distant metastasis at the time of diagnosis.Case report: A 57-year-old woman referred for left adrenal mass (5.5×4.0 cm) two years after the diagnosis of breast cancer. The patient’s medical history revealed hypertension and diabetes mellitus. She has cushingoid and hy...

Diabetes mellitus is a common and growing global health problem leading to several complications. Among these, periodontal diseases are considered as the sixth complication of diabetes. The goals of this cross-sectional study were to assess Turkish diabetic patients’ oral health behaviors and association with demographic characteristics, access to dental care and need for improved health education. The study sample consisted of 121 diabetic patients (43 M/78 F), with a me...