Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep359 | Reproductive and Developmental Endocrinology | ECE2024

Klinefelter syndrome (KS) prevalence at invasive prenatal diagnosis (ipd) procedures: a systematic review of the literature

Costantino Francesco , De Vincentis Sara , Chiara Decaroli Maria , Rochira Vincenzo

Introduction: KS prevalence is estimated to range from 0.1-0.2 % in men and actually the estimated frequency is of about 1:500 to 1:1000 men1. However, the real prevalence remains unknown due also to the fact that the disease is often overlooked and undermanaged1.Aim and methods: We performed a systematic literature search including studies published between 1971 and January 2024 to investigate the real prenatal prevalence of KS (in...

ea0081ep851 | Reproductive and Developmental Endocrinology | ECE2022

Eunuchoid skeletal proportions in male hypogonadism: a comparative analysis of anthropometric measures between men with congenital hypogonadotropic hypogonadism (CHH) and Klinefelter Syndrome (KS)

De Vincentis Sara , Corleto Rossella , Bellelli Alessio , Zirilli Lucia , Santamaria Emanuele , Granata Antonio , Rochira Vincenzo

Background: Patients with CHH and KS have eunuchoid body proportions of the skeleton compared to normal male subjects, characterized by tall stature, and reduced upper-to-lower segment ratio (U/l). Vice versa, steroids exposure deeply differs between CHH and KS at puberty, with both testosterone and estradiol being very low only in CHH. At present, body skeletal proportions comparison between CHH and KS is not available.Aim: To compare anthropom...

ea0090p585 | Calcium and Bone | ECE2023

Evidence of a non-classical phenotype of hypoparathyroidism in a cohort of adult patients with iron overload diseases

Evangelisti Selene , De Vincentis Sara , Rossi Barbara , Chiara Decaroli Maria , Locaso Michela , Ferrara Francesca , Rochira Vincenzo

Background: Iron overload disorders (IOD) are associated with a higher occurrence of unbalanced calcium (Ca)-phosphorous (P) metabolism, including hypoparathyroidism (HPT). However, data about prevalence and presentation of HPT in this setting are scanty. A Ca/P ratio <2.32 has been proposed to detect HPT in the general population.Aim: To characterize Ca-P homeostasis, particularly the prevalence of HPT, in a cohort of adult patients with IOD compare...

ea0067o1 | Oral Presentations | EYES2019

Prevalence of thyroid disfunctions in a large cohort of Human Immunodeficiency Virus (HIV)-Infected Patients

Tartaro Giulia , De Vincentis Sara , Brigante Giulia , Diazzi Chiara , Malagoli Andrea , Guaraldi Giovanni , Rochira Vincenzo

Objective: Highly Active Antiretroviral therapy (HAART) has been associated with several endocrine abnormalities. Data concerning thyroid dysfunction in HIV are still controversial. The aim of this study was to investigate the prevalence of thyroid dysfunctions and their association with HAART and HIV-infection in a large cohort of HIV-infected patients.Methods: A retrospective cross-sectional study was carried out involving HIV-infected patients whose t...

ea0049gp146 | Male Reproduction and Endocrine Disruptors | ECE2017

Psychological rather than organic and/or relational components are involved in sexual dysfunction in Young/Middle aged human immunodeficiency virus (HIV)-Infected Men

Decaroli Maria Chiara , De Vincentis Sara , Diazzi Chiara , Zona Stefano , Guaraldi Giovanni , Santi Daniele , Rochira Vincenzo

Background: HIV-infection is associated to an increased prevalence of erectile dysfunction (ED). In HIV-infected men ED seems to be less related to serum Testosterone (T), depending from other factors.Aim: To investigate the role of different components (organic, relational, psychological) of erectile function by using validate questionnaires in HIV-infected men with normal serum T.Methodology: Prospective, cross-sectional, observa...

ea0056p215 | Calcium &amp; Vitamin D metabolism | ECE2018

Reliabilty of serum Calcium to Phosphorus (Ca/P) ratio as an accurate and inexpensive toolto define disorders of Ca-P metabolism: preliminary data

De Vincentis Sara , Monzani Maria Laura , Kara Elda , Guaraldi Giovanni , Rochira Vincenzo , Madeo Bruno

Background: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (>3.5 if Ca and P are expressed in mg/dl) from healthy subjects [1]. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP), might impair the Ca/P ratio.Aim: To ...

ea0090rc8.2 | Rapid Communications 8: Calcium and Bone | ECE2023

Sarcopenia, low bone mineral density and hidden obesity in young adult Men Living with HIV (MLWH): prevalence and relationship with sex steroids

De Vincentis Sara , Decaroli Maria Chiara , Greco Carla , Diazzi Chiara , Fanelli Flaminia , Mezzullo Marco , Pagotto Uberto , Guaraldi Giovanni , Rochira Vincenzo

Background: HIV is associated with decreased bone mineral density (BMD) and decreased muscle mass. Osteoporosis and sarcopenia often co-exist and their onset is multifactorial. Sex steroids play a key role in the homeostasis of bone health and body composition in HIV-uninfected men, but data in MLWH are scanty.Aim: To investigate the frequency of low BMD and sarcopenia and their relationship with gonadal function in MLWH younger than 50.<p class="abs...

ea0035p701 | Male reproduction | ECE2014

Gonadal and sexual function in young/middle aged human immunodeficiency virus (HIV)-infected men

Santi Daniele , Brigante Giulia , Diazzi Chiara , De Vincentis Sara , Zona Stefano , Guaraldi Giovanni , Simoni Manuela , Rochira Vincenzo

Background: HIV-infection is associated to an increased prevalence of age-related comorbidities, such as erectile dysfunction (ED) and testosterone (T)-deficiency.Aim: Definition of ED and T-deficiency in HIV-infected men using validated sexual questionnaires and the gold standard assay for T measurement: isotopic dilution–liquid chromatography–tandem mass spectrometry (ID–LC–MS/MS)Methodology: Prospective, cros...

ea0032p84 | Bone and Osteoporosis | ECE2013

Effects of treatment for acromegaly on bone mineral density: is pegvisomant protective on lumbar BMD?

Brigante Giulia , Santi Daniele , Diazzi Chiara , De Vincentis Sara , Ferrannini Giulia , Madeo Bruno , Carani Cesare , Simoni Manuela , Rochira Vincenzo

Background: GH–IGF1 status is important for bone health. Acromegaly affects bone status, but less is known on the role of treatments for acromegaly on bone mineral density (BMD). Pegvisomant (Peg) is effective in treating acromegaly by reducing IGF1. As serum GH is not influenced by Peg, it is not known if residual, direct GH effects on bone (not IGF1 mediated) are preserved during treatment.Methods: To evaluate the effects of Peg on BMD, we compare...

ea0032p1005 | Thyroid (non-cancer) | ECE2013

TSH-deficiency is associated with a lower thyroid gland volume in hypopituitaric patients compared to healthy volunteers: a cross-sectional study

Santi Daniele , Brigante Giulia , Gnarini Valentina , Madeo Bruno , De Vincentis Sara , Carani Cesare , Faustini-Fustini Marco , Balestrieri Antonio , Rochira Vincenzo

Introduction: Thyroid volume (TV) depends on age, gender, anthropometry, smoking and iodine status. IGF1 plays a role on thyroid growth, as demonstrated in acromegaly and GH-deficiency. Finally, TSH is a well recognised permissive factor for thyroid tissue growth. The aim of the study is to evaluate the long-term effect of TSH-deficiency on TV in hypopituitaric patients compared with healthy volunteers.Methods: We performed a cross-sectional, controlled ...