Searchable abstracts of presentations at key conferences in endocrinology

ea0031p197 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

DPPIV and macronutrients regulate the expression of PYY3–36 in human gut epithelial cells

Kosicka Anna , Renshaw Derek , Zariwala Mohammed Gulrez

The enzyme dipeptidyl peptidase-IV (DPP-IV) is expressed by gut epithelial cells. DPP-IV cleaves X-proline dipeptides from the N-terminus of polypeptide hormones including GLP-1, GIP and PYY. DPP-IV causes a deactivation of the incretin hormones GLP-1 and GIP, whereas conversely, by converting PYY1–36 to PYY3–36 it allows specific activation of the Y2 receptors in the arcuate nucleus of the hypothalamus leading to hypophagia. Infused PYY3–36 has been ...

ea0050p335 | Obesity and Metabolism | SFEBES2017

Investigating the role of Annexin A1 in Adipogenesis and its ability to dampen Obesity associated Inflammation

Sajid Sehar , Renshaw Derek , Burke Bernard , Mee Christopher

Introduction: Obesity results in an imbalance of systemic adipokines as well as pro and anti-inflammatory biomarkers. The attenuation of anti-inflammatory proteins, including Annexin A1 (AnxA1) in human obesity, may be a contributing factor to the chronic inflammatory phenotype which results. However, increased AnxA1 mRNA and protein levels in mature adipocytes suggest an additional role for AnxA1 in adipose tissue biology.Ai...

ea0050p335 | Obesity and Metabolism | SFEBES2017

Investigating the role of Annexin A1 in Adipogenesis and its ability to dampen Obesity associated Inflammation

Sajid Sehar , Renshaw Derek , Burke Bernard , Mee Christopher

Introduction: Obesity results in an imbalance of systemic adipokines as well as pro and anti-inflammatory biomarkers. The attenuation of anti-inflammatory proteins, including Annexin A1 (AnxA1) in human obesity, may be a contributing factor to the chronic inflammatory phenotype which results. However, increased AnxA1 mRNA and protein levels in mature adipocytes suggest an additional role for AnxA1 in adipose tissue biology.Ai...

ea0061cd2.3 | Case Discussions: complex clinical cases 2.0 | OU2019

Exploring the roles of Annexin A1 in adipocytes using an in vitro model of obesity

Sajid Sehar , Burke Bernard , Mee Christopher , Renshaw Derek

Introduction: Adipose tissue oxygen consumption and blood flow are altered in obesity inducing local tissue hypoxia. Hypoxia affects several biological functions including adipogenesis, inflammation, insulin resistance and metabolism affecting the overall degree of adiposity. The expression of Annexin A1 (ANXA1); an anti-inflammatory protein, increases in the adipose tissue in response to obesity and further increases in the subcutaneous adipose tissue of old obese individuals...

ea0061p004 | (1) | OU2019

Evidence of aberrant inflammation in patients with Lipodystrophy

Sajid Sehar , Burke Bernard , Mee Christopher , Savage David , Renshaw Derek

Introduction: Lipodystrophy is a rare medical condition with a varied etiology that is characterised by a complete or partial loss of adipose tissue, which can be generalised, partial or localised. Patients have altered secretion of adipokines, such as, Leptin and Adiponectin. Ectopic lipid accumulation is common and leads to metabolic complications associated with insulin resistance (IR) such as, diabetes mellitus (DM) and hypertriglyceridemia. Levels of circulating inflammat...

ea0034p255 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Serum ferritin levels are correlated with total adiposity, but not BMI in obese males

Zariwala M Gulrez , Kosicka Ania , Mackenzie Richard , Renshaw Derek

According to the World Health Organisation iron deficiency is the most prevalent form of under-nutrition worldwide. Historically, the causes of iron deficiency were related principally to nutritional deficiencies and this remains a significant factor in many parts of the developing world. However, obesity is also a known cause of iron deficiency and is increasingly correlated with altered iron status and iron deficiency in affected individuals. As the obesity epidemic spreads ...

ea0031p136 | Cytokines and growth factors | SFEBES2013

Effect of acute hypoxia upon myostatin expression in healthy individuals

Elliott Bradley , Renshaw Derek , Getting Stephen , Watt Peter , Mackenzie Richard

We previously showed acute hypoxic conditions result in atrophy of myotubes in vitro. Chronic hypoxic exposure in vivo induces muscular atrophy in healthy mountaineering individuals and patients with COPD. Myotubes in vitro increase myostatin expression in response to hypoxic exposure. Further, hypoxic COPD patients show cachexia and increased serum myostatin expression. However, in vivo results are cofounded by disease factors in COPD patie...

ea0021p355 | Steroids | SFEBES2009

Salivary annexin 1 has a diurnal rhythm but does not share an awakening response with cortisol at 30 min

Renshaw Derek , Korbonits Marta , Flower Rod , Perretti Mauro , Fowkes Robert

Several hormones, including cortisol, have a circadian rhythm in plasma and saliva. Salivary cortisol is now extensively used for screening and following patients with various conditions where the regulation of hypothalamo-pituitary–adrenal axis is abnormal, for example in major depression where salivary cortisol levels show a disruption or loss of the circadian rhythm.Annexin 1 is a glucocorticoid-induced protein, which is responsible for mediating...

ea0015p330 | Steroids | SFEBES2008

Salivary cortisol: a possible regulator of salivary annexin 1

Renshaw Derek , Mancini Lucia , Flower Rod , Perretti Mauro

Several hormones, including cortisol, have a circadian rhythm in plasma and saliva. Salivary cortisol is now extensively used for screening and following patients with various conditions where the regulation of hypothalamo–pituitary–adrenal axis is abnormal, for example in major depression where salivary cortisol levels show a disruption or loss of circadian rhythm. Annexin 1 is a glucocorticoid-induced protein, which is responsible for mediating several anti-inflamm...

ea0077p184 | Metabolism, Obesity and Diabetes | SFEBES2021

Does human serum impact differentiation and mitochondrial function of human LHCN-M2 skeletal muscle cells?

Turner Mark , Saini Amarjit , Brown Holly , Anisi Sara , Stewart Claire , Renshaw Derek

Introduction: Skeletal muscle cells enable investigation of myogenesis and metabolic function in vitro. Exposure to human serum can provide insight into the impact of endocrine factors upon differentiation and mitochondrial function of skeletal muscle. The aim of these experiments was to optimise the culture conditions using human serum, which it was hypothesised would enhance myogenesis and mitochondrial function of LHCN-M2 human skeletal muscle cells.<p class="a...