Endocrine Abstracts

Introduction: Von Hippel–Lindau (VHL) disease is a rare disorder, characterized by the development of a variety of benign and malignant tumors. It is autosomal dominantly inherited disease that causes retinal or central nervous system hemangioblastomas, endolymphatic sac tumors, renal cell carcinomas, pancreatic cysts and tumors, pheochromocytoma and epididymal cystadenomas. The condition is associated with inactivation of a tumor suppression gene.C...

Diabetic mothers have an increased risk for pregnancy (early pregnancy loss, polyhydramnios, pre-eclampsia, premature labor) and progression of diabetic complications. We present a case of the progression of diabetic-related complications including autonomic neuropathy (AN) which caused severe vomiting during pregnancy. A 27-year-old type 1 diabetic woman with pregnancy of 8 weeks gestational age (GW) was admitted to our hospital for glycemia and diabetic-related complications...

Objective: To document the incidence of type 1 diabetes mellitus in Lithuanian 15–39 years of age population from 1991 to 2012.Research design and methods: A specifically developed contact system with all endocrinologists and diabetologists and general practitioners involved in the diabetes care covering 100% of the Lithuanian population aged 15–39, was the initial data source. Annual reports from regional family physicians, endocrinologist&#14...

Annexin A1 (ANXA1), a Ca2+ and phospholipid binding protein, serves as a paracrine/justacrine mediator of glucocorticoid action in the neuroendocrine system. Within the anterior pituitary gland ANXA1 is produced by folliculo-stellate (FS) cells and, following serine-27 phosphorylation (Ser27-P) and membrane translocation, acts on adjoining corticotroph cells to suppress ACTH release via a mechanism involving formyl peptide receptor (FPR) activation. To ex...

Introduction: Struma ovarii (SO) is a rare ovarian tumor that occurs as part of a teratoma or is found in serous or mucinous cystadenomas and consist of more than 50% thyroid tissue. More uncommon is to diagnose thyroid cancer in struma ovarii and thyroid gland of two different origins. We present a case of follicular thyroid carcinoma arising in struma ovarii of the right ovary and papillary thyroid gland carcinoma.Case: A 70-year-old woman admitted to ...

Introduction: Aortic dilation (AD) is the life threating complication of Turner syndrome (TS). The reported prevalence of AD in TS various between 12 and 39%. Factors predicting enlargement of diameter of aorta (DA) are still under investigation.Aim: To assess the prevalence of AD in TS in Lithuanian population, to evaluate the possible predictors of AD development.Methods: Forty-three patients with TS aged ≥18 year were enro...

We have previously demonstrated that in experimental Parkinson’s disease local production of oestrogens protects against striatal dopamine loss in vivo (Gillies GE. et al. Pharmacol Biochem Behav. 2004;78:513–22). As neurodegenerative disease is invariably accompanied by neuroinflammation, much interest has focused on oestrogen receptor (ER)-dependent suppression of inflammatory activation of microglia, the primary innate immune cell-type in the brain, ...

The main pathological finding in Parkinson’s disease (PD) is the loss of dopaminergic cells in the substantia nigra (SNc). Current dopamine-replacement therapies alleviate symptoms but do not prevent disease progression. The pathophysiology of PD is unknown, but oxidative stress and neuroinflammation have been implicated. A better understanding of the cause of dopaminergic cell death may lead to the discovery of new therapies that can slow disease progression.<p class...

Introduction: Turner syndrome (TS) is associated with specific physical features, as well as a particular neuropsychological profile and social and behavioral features. It is common practice in the case of TS to treat short stature with growth hormone preparations and to induce puberty with estrogens at an age as close to normal puberty as possible. Nevertheless results of some studies show that despite the treatment, some women with TS still experience psychosocial problems, ...

Introduction: Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare, autosomal dominantly inherited syndrome that causes tumors of the endocrine glands [1]. This syndrome is most commonly associated with neuroendocrine tumors of the parathyroid glands, pituitary gland and pancreas [2].Case: A 30-year-old woman was admitted to the Hospital of Lithuanian University of Health Sciences, Kaunas Clinics for unconsciousness and significant hypoglycaemia: 1.0 - 3...