Searchable abstracts of presentations at key conferences in endocrinology

ea0077op6.3 | Endocrine Cancer and Late Effects | SFEBES2021

An unusual presentation of hypoglycaemia: An investigative challenge

Chia Eng Pei , Avari Parizad , Chen Runzi , Spalding Duncan , Oliver Nick , Wernig Florian

Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones such as pro-opiomelanocortin, proinsulin, proglucagon into biologically active peptides. Inherited genomic mutations of PCSK1 present with malabsorptive diarrhoea, hyperinsulinemic hypoglycaemia, central adrenal and thyroid defects and severe obesity. Somatic mutations of insulinomas are associated with genetic defects interfering with insulin secreti...

ea0086p303 | Adrenal and Cardiovascular | SFEBES2022

Prednisone is 100% converted to Prednisolone by first pass metabolism

Chia Eng Pei , Lazarus Kate , Narula Kavita , Choudhury Sirazum , Tan Tricia , Meeran Karim

Prednisolone is widely prescribed in the UK, whereas prednisone is used instead for the same indications in the United States. Both have utility as anti-inflammatory agents and for use as glucocorticoid replacement therapy at lower doses. Oral prednisone is converted to prednisolone by first pass hepatic metabolism by 11 beta HSD-1. This study was undertaken to compare the bioavailability of prednisone against prednisolone. To determine the conversion of prednisone to predniso...

ea0038p41 | Clinical biochemistry | SFEBES2015

Audit of the diagnosis and management of primary hyperparathyroidism

Eng Pei Chia , Lorna Langstaff , Felicity Kaplan , George Mochloulis , Peter Winocour

Introduction: Primary hyperparathyroidism (PHPT) is a clinical condition often recognized as a result of biochemical screening. While surgery is indicated in symptomatic hypercalcaemic states, the need and timing of surgery in asymptomatic patients is not always clearcut. We conducted a retrospective audit on the diagnosis and management of primary hyperparathyroidism between the years 2010 and 2014.Method: Patients were identified through our histopatho...

ea0077op4.4 | Metabolism, Obesity and Diabetes | SFEBES2021

Audit of Clinical Outcomes with Dexamethasone in Patients Hospitalised with COVID-19

Narendranathan Divani , Richards Molly , Cassin-Scott Rebecca , Chia Eng Pei , Distaso Walter , Tan Tricia , Izzy-Engbeaya Chioma , Salem Victoria

Background: Dexamethasone significantly improved outcomes in patients requiring supplementary oxygen and in ventilated patients with COVID-19 in the RECOVERY trial. Consequently, dexamethasone is now routinely used in these patients. However, dysglycaemia is commonly associated with steroid use and is an established risk factor for poorer outcomes in COVID-19. In this study, we aimed to elucidate the effect of dexamethasone use in patients hospitalised with COVID-19 in a real-...

ea0077p186 | Metabolism, Obesity and Diabetes | SFEBES2021

Predictors of adverse outcomes in COVID-19: A retrospective cohort study comparing the first two waves of COVID-19 hospital admissions in London, with a focus on diabetes

Hashmi Durreshahwar , Shaikhali Yusuf , Cassin-Scott Rebecca , Eng Pei , Distaso Walter , Tan Tricia , Salem Victoria , Izzy-Engbeaya Chioma

Introduction: Diabetes has been associated with poorer outcomes with COVID-19 infection, but precise predictors of mortality in patients with diabetes remain unclear. We assessed predictors of adverse outcomes in patients hospitalised with COVID-19 in Imperial College Healthcare NHS Trust (ICHNT) hospitals during the first and second waves of COVID-19 to determine if outcomes for patients with diabetes have evolved with new variants and treatments.Method...

ea0081ep999 | Thyroid | ECE2022

Serum selenium status in UK Graves’ disease patients with and without orbitopathy

Maden Carla , Eng Pei Chia , Choa Dri , Agha-Jaffar Rochan , Cox Jeremy , Yee Michael , Robinson Stephen , Fayers Tessa

Introduction: Selenium supplementation is recommended for all patients with mild Graves’ orbitopathy (GO). The thyroid gland contains high levels of selenium, which has an anti-oxidant effect and a role in the metabolism of thyroid hormones. The study on which this recommendation is based was conducted in countries of a selenium-deficient region and did not measure subjects’ selenium concentrations. There is therefore no consensus on optimum dose, duration, or safety...

ea0081ep1099 | Thyroid | ECE2022

COVID-19 vaccine-associated subacute thyroiditis

Chia Eng Pei , Davidson Lien , Agha-Jaffar Rochan , Cox Jeremy , Yee Michael , Moriarty Maura , Robinson Stephen , Vakilgilani Tannaz , Bravis Vassiliki

Introduction: Subactue thyroiditis (SAT) is a self-limiting inflammatory condition caused by follicular destruction of the thyroid gland, commonly precipitated by viral upper respiratory tract infection 2 weeks preceding the onset of thyroid symptoms. However, SAT following COVID-19 vaccination is rare. Herein, we report two cases of subacute thyroiditis which presented after administration of COVID-19 vaccine. Case series: The first patient was a 42 yea...

ea0086p311 | Bone and Calcium | SFEBES2022

Comparison of newly derived and existing formulae for the estimation of biologically active calcium

Salih Ahmed , Phylactou Maria , Comninos Alexander , Labib Marina , Chia Eng Pei , Clarke Sophie , Tan Tricia , Moore Pope , Cegla Jaimini , Dhillo Waljit , Abbara Ali

Introduction: Free ionised calcium is the biologically active component of total circulating calcium but is infrequently measured due to sampling requirements. Therefore, total calcium is ‘adjusted’ for albumin to provide a closer estimate of the biologically active ionised calcium level (e.g. James, Orell, Payne and Berry formulae). Here, we aim to derive a novel equation to estimate ionised calcium from readily available biochemical parameters and compare its perfo...

ea0086p326 | Metabolism, Obesity and Diabetes | SFEBES2022

Examining the relationship between gestational diabetes, maternal pre-pregnancy body mass index (BMI) and large for gestation age neonates by ethnicity

Chia Eng Pei , Veidi Chiara , Mullins Edward , Terry Jayne , Jones Bryony , Dornhorst Anne , Uduku Chukwuma , Sykes Lynne , Yu Christina , Robinson Stephen , Agha-Jaffar Rochan

Objective: To determine if the impact of pre-pregnancy body mass index (BMI), fasting glucose levels and post load glucose levels on large for gestational age neonates varies with ethnicity.Data sources: Electronic health records of all eligible pregnant women in an inner city service. Study designRetrospective analysis of pregnant women at risk of developing gestational diabetes mellitus (2016-2019) of. Population or sampleEligible pregnant women. Synth...

ea0090rc10.2 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2023

Increased risk of cirrhosis in post-menopausal women with NAFLD

Izzi-Engbeaya Chioma , Eng Pei , Dunin-Borkowska Aleksandra , Forlano Roberta , Mullish Benjamin H , Sigon Giordano , Lin Vicky , Tan Tricia , Yee Michael , Manousou Pinelopi , Dhillo Waljit

Background: Non-alcoholic liver disease (NAFLD) affects up to 30% of adults worldwide. With the prevalence of NAFLD increasing after menopause, women aged >55 years are more likely to progress to advanced fibrosis than men. Moreover, liver decompensation secondary to NAFLD is more frequent in women compared to men. However, the causes of these differential outcomes are not fully understood.Methodology: We performed a retrospective cohort study utilis...