Endocrine Abstracts

Traumatic brain injury (TBI) which is a worldwide public health problem has been recently recognized as a cause of neuroendocrine dysfunction. Pituitary dysfunction due to TBI may be partial or complete and in retrospective studies as many as 25–50% of patients have been demonstrated to have some degree of pituitary hormone deficiencies. Recently five prospective studies investigating the 12 months follow-up of anterior pituitary function after TBI have been published. Ba...

Introduction: We investigated the levels of IGF1 in acute myocardial infarction (AMI) and sought to determine whether a decrease might influence the long-term prognosis.Material and methods: Sixty-five patients who were admitted to our hospital with AMI were included in the study along with 26 other patients without coronary artery disease (CAD) who served as the control group. Fasting blood samples of all of the patients with AMI were obtained at the ho...

Background: Type 1 DM has been shown to be associated with increased rate of hyperandrogenemia, polycystic ovarian changes (PCO) and PCOS. Although stimulated 17-OH progesterone responses to leuprolide has previously been shown to be increased in pubertal girls with type 1 DM, the effect of gonadotropin releasing hormone analog stimulation has not been studied in adult women.Materials and methods: Fifty-two adult women with type 1 DM and 15 healthy adult...

Objective: GH deficiency is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to determine i) serum PON1 activities, an established lipid antioxidant, ii) MDA levels which are end products of lipid peroxidation induced by ROS and iii) thiol groups as an antioxidant for evaluating oxidative stress in patients with GHD before and aft...

Objective: To investigate the clinical efficacy and safety of the finasteride (5 mg/day) plus flutamide (125 mg/day) combination therapy in unselected women with moderate to severe hirsutism.Patients and methods: Thirty hirsute women were randomly assigned to two treatment groups. Sixteen patients (group 1) were treated with flutamide (125 mg per day) and 14 patients (group 2) were treated with finasteride (5 mg per day) plus flutamide (125 mg per day) f...

The low-dose (1 μg) ACTH stimulation test or glucagon stimulation test (GST) are candidate tests for hypothalamo-pituitary-adrenal (HPA) axis evaluation in patients with pituitary disorders. In this study, we aimed to compare the combination of low-dose ACTH and GSTs (named as combination test) with each test results alone in the evaluation of HPA axis in patients with pituitary disorders whether combination test may overcome the problems when the test results are equivoc...

Introduction: Patients with Cushing’s Syndrome (CS) frequently have sleep complaints. The aim of the study was to evaluate the prevalance sleep disturbances and sleep structure of patients with CS.Materials and methods: 33 patients with CS were evaluated both clinically and with polysomnograhy (PSG) findings in terms of sleep disorders and data were compared with 20 healthy controls.Results: Seventeen (51.1%) patients with CS ...

Background: Acne, stria and decreased skin elasticity are dermatological features of Cushing’s syndrome (CS). Although it is known that collagen mass in skin is decreased in CS and glucocorticoids play a role in acneiform skin lesions, the dermatological findings of CS has not previously been measured by reliable methods.Objective: The aim of the present study was to measure skin elasticity, capacitance, sebum content, pH and temperature in CS befor...

Aim: Although there are some studies regarding the effects of cigarette smoking on serum total cortisol (STC) and salivary cortisol (SaC) levels, the results are still challenging. For this purpose, we aimed to determine the effects of cigarette smoking on STC and/ or SaC levels in a small group of healthy volunteers.Study design: 15 (five female and ten male) cigarette smoker with the mean age of 39.47±14.27, and 15 age and gender matched non-smoke...

Introduction: Appropriate replacement therapy of not only gonadotrophins, but other deficient pituitary hormones is important in patients with hypopituitarism for a successful pregnancy. Data regarding GH replacement therapy during pregnancy is limited. We would like to present a case with panhypopituitarism including severe GH deficiency due to Sheehan’s syndrome, who achieved successful pregnancy with GH replacement therapy in the first half of pregnancy.<p class="a...