Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep794 | Reproductive and Developmental Endocrinology | ECE2020

Investigating the impact of preoperative obesity-associated hyperandrogenemia in women and hypogonadism in men on weight loss following bariatric surgery

Beiglböck Hannes , Fellinger Paul , Ranzenberger-Haider Tamara , Itariu Bianca , Prager Gerhard , Kautzky-Willer Alexandra , Krebs Michael , Wolf Peter

Background: In severe obesity, hypogonadism in men and androgen excess in women are frequently observed. Sex hormones play an important role in body composition, glucose and lipid metabolism. Bariatric surgery is the most effective treatment strategy to combat morbid obesity. However, if preoperative gonadal dysfunction impacts weight loss and metabolic improvements after surgery is not known.Methods: 49 men and 104 women were included in a retrospective...

ea0070ep341 | Pituitary and Neuroendocrinology | ECE2020

Long-term-follow-up of patients with gastric bypass surgery secondary to craniopharyngioma associated hypothalamic obesity

Beiglböck Hannes , Fellinger Paul , Ranzenberger-Haider Tamara , Vila Greisa , Luger Anton , Kautzky-Willer Alexandra , Krebs Michael , Wolf Peter

Background: Patients being cured of craniopharyngioma (CP) often suffer from severe hypothalamic obesity due to tumor localization or therapeutic interventions, which has a major impact on increased mortality and reduced quality of life. Gastric bypass surgery (GBS) was suggested to be an effective therapeutic option for weight reduction in those patients. However, long-term changes in body weight and postsurgical complications are unknown.Methods: 5 pat...

ea0081p403 | Pituitary and Neuroendocrinology | ECE2022

GH/IGF-I impact hepatic lipid accumulation in non-acromegalic individuals with and without non-alcoholic fatty liver disease

Fellinger Paul , Beiglboeck Hannes , Pfleger Lorenz , Smajis Sabina , Gajdosik Martin , Marculescu Rodrig , Vila Greisa , Winhofer Yvonne , Kautzky-Willer Alexandra , Krebs Michael , Krssak Martin , Wolf Peter

Background: Growth hormone (GH) plays an important role in modifying body composition. In acromegaly, a state of chronic GH/IGF-I excess, visceral and ectopic fat mass, especially in the liver, are significantly reduced. The aim of this study was to investigate the impact of GH/IGF-I on hepatocellular lipid content (HCL) and energy metabolism in a non-acromegalic cohort of patients with and without non-alcoholic fatty liver disease (NAFLD).Methods: We pe...

ea0063gp189 | Adrenal and Neuroendocrine - Clinical | ECE2019

Plasma renin concentration is associated with cardiac function and morphology in primary adrenal insufficiency

Wolf Peter , Beiglbock Hannes , Fellinger Paul , Pfleger Lorenz , Aschauer Stefan , Gessl Alois , Trattnig Siegfried , Kautzky-Willer Alexandra , Luger Anton , Winhofer Yvonne , Krssak Martin , Krebs Michael

Background: Despite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, primary adrenal insufficiency (AI) is associated with an increased mortality, mainly due to cardiovascular disease. The role of MC replacement is not known. Therefore we assessed whether renin concentrations during routine GC and MC substitution therapy are associated with cardiac function and morphology.Methods: 17 patients with AI underwent magnetic resonan...

ea0090ep744 | Pituitary and Neuroendocrinology | ECE2023

Growth hormone treatment tends to promote hepatic VLDL1-triglyceride export in humans

Baumgartner Clemens , Metz Matthaeus , Schnait Franziska , Tosin Anna , Beghini Marianna , Fellinger Paul , Beiglboeck Hannes , Pfleger Lorenz , Vila Greisa , Luger Anton , Kautzky-Willer Alexandra , Stangl Herbert , Krssak Martin , Furnsinn Clemens , Scherer Thomas , Krebs Michael , Wolf Peter

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a systemic, metabolic condition associated with increased morbidity and mortality. Defined by an increase in hepatic lipid content (HCL), NAFLD develops in consequence of lipid oversupply and/or a diminished disposal of hepatic lipids. The latter may include an impaired export of triglycerides (TG) via the secretion of very-low density lipoprotein1 (VLDL1) particles, an important mechanism of the liver to protect itsel...

ea0073aep62 | Adrenal and Cardiovascular Endocrinology | ECE2021

Patients with congenital adrenal hyperplasia show an adverse cardiovascular risk profile compared to patients with autoimmune adrenalitis

Hannes Beiglböck , Magdalena Bögl , Fellinger Paul , Metz Matthaeus , Vila Greisa , Luger Anton , Trattnig Siegfried , Kautzky-Willer Alexandra , Krssak Martin , Krebs Michael , Peter Wolf

BackgroundDespite adequate hormone replacement therapy, evidence suggests an increased mortality in patients suffering from primary adrenal insufficiency, mainly because of cardiovascular diseases. Congenital adrenal hyperplasia (CAH) and autoimmune adrenalitis (AI) are two entities with a different pathophysiological background and might therefore show divergent cardiovascular risk profiles.Methods9 patients...

ea0099oc12.3 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | Part II | ECE2024

Growth hormone promotes in-vivo hepatic triglyceride export in humans

Baumgartner Clemens , Metz Matthaeus , Pfleger Lorenz , Tosin Anna , Beghini Marianna , Beiglboeck Hannes , Fellinger Paul , Schnait Franziska , Vila Greisa , Luger Anton , Kautzky-Willer Alexandra , Freudenthaler Angelika , Baumgartner-Parzer Sabina , Stangl Herbert , Krssak Martin , Scherer Thomas , Krebs Michael , Wolf Peter

Overview: Non-alcoholic fatty liver disease (NAFLD) is defined as a chronic increase in intrahepatic lipids (IHL). A surplus of IHL can be compensated through increased lipid export via very-low density lipoprotein (VLDL) particles. Growth hormone (GH) is known to reduce visceral and ectopic fat. However, the main pathways responsible for the in-vivo decrease of IHL under the influence of GH are yet to be determined.Methods: We assessed hepatic lipid met...

ea0099rc5.7 | Rapid Communications 5: Pituitary and Neuroendocrinology | Part I | ECE2024

Changes of hepatic metabolism and lipidomic profile with biochemical improvement of acromegaly

Fellinger Paul , Pfleger Lorenz , Beiglboeck Hannes , Baumgartner Clemens , Marella Nara , Micko Alexander , Wolfsberger Stefan , Vila Greisa , Lmger Anton , Kautzky-Willer Alexandra , Krssak Martin , Scherer Thomas , Wolf Peter , Krebs Michael , Winhofer Yvonne

Overview: Despite marked insulin resistance, patients with active acromegaly have low hepatocellular lipid content (IHL) and an unfavourable hepatic lipid composition (UI). As previously shown, inadequate mitochondrial activity in the liver might counteract lipid accumulation in the liver. The purpose of this study was to understand changes in hepatic metabolism, and lipidomic profile with therapy of acromegaly.Methods: We prospectively included thirteen...