Searchable abstracts of presentations at key conferences in endocrinology

ea0090p496 | Thyroid | ECE2023

Amyloid Goiter, Papillary Thyroid Microcarcinoma and Diffuse Thyroid Lipomatosis – a case report of a rare association

de Assuncao Guilherme V. , Fonseca Liliana , Couto de Carvalho Andre , Freitas Claudia

Introduction: Amyloidosis is a disease characterized by the accumulation of an amorphous proteinaceous material, known as amyloid, in various organs and tissues of the body. Amyloid goiter is a remarkably rare pathologic condition due to thyroid massive amyloid infiltration of amyloid light chain (primary) or amyloid A (secondary amyloidosis) proteins. Case: 54 year-old male, with known history of chronic tophaceous gout medicated with anakinra and predn...

ea0090ep206 | Calcium and Bone | ECE2023

Severe PTH-dependent Hypercalcemia Secondary to Atypical Parathyroid Adenoma

Maia Ariana , Fonseca Liliana , Viveiros Ana Luisa , Neves Joao , Cardoso Helena

Introduction: Hypercalcemia is not uncommon in clinical practice and may present as a life-threatening emergency. Its main aetiologies are primary hyperparathyroidism (80% parathyroid adenomas; 20% multiglandular hyperplasia, <1% parathyroid carcinomas) and hypercalcemia of malignancy, with or without presence of bone metastases.Case Report: We present a case of a 77 years-old male, submitted to a subtotal gastrectomy at the age of 73 due to a perfor...

ea0049ep824 | Steroid metabolism + action | ECE2017

Ritonavir induced Cushing’s Syndrome in a patient under inhaled corticosteroids

Pereira Teresa Alves , Furtado Ines , Lopes Ana M , Fonseca Liliana , Palma Isabel

Introduction: Cushing’s Syndrome secondary to inhaled or topic corticosteroids is very rare, although there are reports of a link to cytochrome inhibitors. Ritonavir, a protease inhibitor used for treatment in human immunodeficiency virus (HIV) infection, is a potent inhibitor of cytochrome P450 3A4.The case: A 41 years old man - with personal history of asthma, HIV infection diagnosed in 2002 and hepatitis C infection since 1999 – was sent to ...

ea0049ep921 | Neuroendocrinology | ECE2017

Kallmann syndrome: about eleven clinical cases

Fonseca Liliana , Amaral Claudia , Dores Jorge , Palma Isabel , Carvalho Rui , Cardoso Helena , Vilaverde Joana , Borges Fatima

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...

ea0070ep235 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Flash glucose monitoring in type 1 diabetes: Real world data

Borges Duarte Diana , Santos Tiago , Fonseca Liliana , Teixeira Sofia , Vilaverde Joana , Cardoso Maria Helena

Introduction: Clinical trial data demonstrate improved glycemic control in individuals with type 1 diabetes (T1D),especially, reduction of time in hypoglycaemia with flash glucose monitoring (FGM);however real-life conditions can modify this scenario.Aim: To examine real world use and glycemic control following a standardized initiation process of FGM.Methods: Individuals aged 18 years or older with T1D were prospectively recruited...

ea0056p313 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Metabolic syndrome and triglyceride-rich lipoproteins

Paredes Silvia , Fonseca Liliana , Carlos Oliveira Jose , Ramos Helena , Palma Isabel

Introduction: Hypertriglyceridemia, a cardinal feature of metabolic syndrome (MS), is associated with cardiovascular disease and abnormal metabolism of apolipoproteins which may form the basis for this relationship. The aim of this study is to evaluate triglyceride-rich lipoproteins profile in MS patients.Material and methods: A retrospective study was performed, including patients evaluated in a tertiary hospital. Patients with thyroid dysfunction, neop...

ea0056p316 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Identifying metabolic unhealthy obesity using the product of triglycerides and glucose

Fonseca Liliana , Paredes Silvia , Carlos Olivera Jose , Ramos Helena , Palma Isabel

Introduction: There are significant physiologically and clinically differences in profiles between metabolic healthy and metabolic unhealthy obese individuals. Several markers are on study in order to better characterize the metabolic profile of metabolic unhealthy obese individuals. The aim of this work was to determine whether the triglycerides/glucose (TyG) index may be a valuable marker for identifying metabolically unhealthy obesity.Methodology: Met...

ea0081ep375 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Phenotypical variability in hepatocyte nuclear transcription factor 1 beta (HNF1β) gene mutation – A five case report

V de Assuncao Guilherme , Fonseca Liliana , Mendes Catarina , Teixeira Sofia , Joao Oliveira Maria , Dores Jorge , Borges Teresa , Cardoso Helena

Introduction: MODY 5 is a rare form of autosomal dominant monogenic diabetes with a broad phenotypical spectrum that occurs with pancreatic and extra-pancreatic clinical manifestations, such as: malformation and dysfunction of the pancreas, nephrourologic anomalies, impaired renal function, hepatopathy and neurocognitive defects. It is caused by a mutation of the gene encoding hepatocyte nuclear transcription factor 1 beta (HNF1β).Case 1: M...

ea0056p719 | Clinical case reports - Pituitary/Adrenal | ECE2018

From adrenal incidentalomas to Cushing’s disease

Alves Pereira Teresa , Ferreira Lia , Furtado Ines , Lopes Ana , Fonseca Liliana , Amaral Claudia , Palma Isabel , Cardoso Helena

Introduction: Adrenal incidentalomas are asymptomatic adrenal masses found accidentally during routine examination, not intended for adrenal pathology evaluation. The functionality of these lesions must be further investigated. Rarely, bilateral adrenal nodular hyperplasia can be detected in a patient with Cushing’s disease. The authors present the case of a patient with possible autonomous cortisol secretion of adrenal origin that eventually emerged as Cushing’s dis...

ea0056ep15 | Adrenal and Neuroendocrine Tumours | ECE2018

IGF-2-oma: a diagnosis to be considered in a patient with a leiomyosarcoma and recurrent hypoglycemia

Fonseca Liliana , Ferreira Lia , Pereira Teresa Alves , Lopes Ana , Almeida Raquel , Vilaverde Joana , Pereira Maria Teresa , Cardoso Helena

Introduction: Non-islet cell tumor induced hypoglycemia (NICTH) is a paraneoplastic phenomenon involving many types of tumors. It is associated with the secretion of incompletely processed precursors of IGF-2 resulting in a persistent insulin-like activity and hypoglycemia. Most commonly, IGF-2–linked hypoglycemia has been observed in patients with solid mesenchymal or epithelial tumors. Typically, elevated IGF-2 levels are associated with suppressed plasma levels of insu...