Endocrine Abstracts

Background: Linear growth is often impaired after successful liver transplantation. Factors that negatively impacted growth are age, graft function and corticosteroid immunosuppression. Short-statured prepubertal liver transplant recipients who do not show sufficient compensatory growth after transplantation benefit from treatment with recombinant human growth hormone (rhGH).Cas report: We communicate the results after the first year of rhGH treatment in...

Background: Lu-NETs are a heterogeneous family of neoplasms ranging from quite indolent lesions with extremely aggressive tumors with very poor prognosis. These neuroendocrine entities are further summarized into two groups according to their biological aggressiveness: Well-differentiated: carcinoids typical (G1) and atypical (G2).Poorly-differentiate: SCLC (Combined) and LCNEC (Combined) (G3). Alarm signal on the aggressive evolution of the SCLCCase rep...

Objectives: To evaluate the effect of alendronate, alfacalcidol, and combinat agent of alendronate and alfacalcidol, in BMD change assess by Digital X-ray Radiogrammetry in postmenopausal women.Materials and methods: Nine thousand and two hundred and sixty four healthy women with ages between 20 and 89 years referred to our densitometry service using DXR-BMD. Six thousand and six hundred and twelve from these were in postmenopause. Using WHO-criteria for...

One of the clinical complications associated with the long term use of bisphosphonates treatment in osteoporosis is the atypical femoral fracture (AFF).Even the absolute risk is low and acceptable compared with the number of fractures prevented, there are still reasonable concerns due to the wide prescription of bisphosphonates and the existence of several case series proving that bisphosphonates have a strong association with this unique fracture type. We present a case of a ...

Transsphenoidal surgery still appears to be the best option for most of the patients with GH secreting adenomas. In many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Alternatives include medical therapy with somatostatin analogues, GH-receptor antagonists and dopamine agonists. These drugs can be used alone or in combination. Radiation therapy with conventional fractionated photons or radiosurgery with proton beam could also be eff...

Introduction: We studied the relationship between vitamin D deficiency and tuberculin skin test (TST) to assess the delayed cellular immunity in older age home residents.Design: This was a case–control study.Methods: We evaluated TST in 50 nursing home residents (35 women and 15 men, aged 58–89 years) with 25-hydroxyvitamin D (25(OH)D) concentrations <50 nmol. A one-stage TST was performed using 0.1 ml of PPD RT23. An...

Introduction: GH therapy (rhGH) improves growth outcome in children born small for gestational age (SGA). Growth velocity is maximum in the first year of therapy. Early diagnosis and treatment optimizes the final height.Objectives: Evaluation of efficacy and safety profile in the first 3 years of rhGH treatment in ten SGA children.Methods: The study enrolled ten SGA children (6 boys, 4 girls). All patients were given a mean dose of...

Introduction: Somatostatin analogs, formerly used as adjuvants in acromegaly treatment, are widely used as primary treatment today.Objective: To investigate the efficacy of octreotide therapy in acromegalic patients as primary or secondary therapy.Materials and methods: Four acromegalic patients diagnosed at the Endocrinological Clinic (males, mean age 35–75 years, age range 26–49 years, all patients with macroadenoma) we...

Introduction: In Romania, the prevalence of postmenopausal osteoporosis in urban centers was estimated by a study in 2007 to be 16.5%. Using alendronate we are increasing bone mineral density and reducing bone turn-over in women with postmenopausal osteoporosis.Materials and methods: There were examined 55 postmenopausal women with osteoporosis (average age 62±4.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer ...

Aim: To evaluate the effect of risedronate vs ibandronate in treatment of systemic osteoporosis in postmenopausal women.Materials and methods: We examined 57 postmenopausal women with systemic osteoporosis (average age 61±3.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer (HOLOGIC Delphi W; SN 7044909) on lumbar spine. Examination was performed before the onset of treatment and after a period of 1, 2 and 3 year...