Searchable abstracts of presentations at key conferences in endocrinology

ea0056p585 | Obesity | ECE2018

Relationship between human adipose tissue autophagy, obesity and glycemic status

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Lhamyani Said , Gentile Adriana-Mariel , Alcaide-Torres Juan , bekay Rajaa El , Tinahones Francisco J

Introduction and aims: Autophagy is an essential process for cell homeostasis that implies recycling and degradation of damaged organelles and long-lived proteins. It is induced during caloric restriction (in order to obtain energy) or other stress-inducing conditions. Autophagy is initiated by autophagosome formation, a double-membrane vesicle which engulfs cellular components and delivers them for degradation by fusing with lysosomes. Thus, proper autophagy regulation favour...

ea0081ep258 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of mimic-mir-21/au@ nanosystem on browning activation: a possible therapeutic tool against obesity

Lhamyani Said , Gentile Adriana-Mariel , Giraldez Perez Rosa Maria , Grueso Elia , Mengual Mesa Maria , Estepa Enrique , Olveira Gabriel , Tinahones Francisco-Jose , Bekay Rajaa El

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

ea0070aep1022 | Hot topics (including COVID-19) | ECE2020

miRNAs regulating BDNF and BDNFas in adipose tissue: Potential link between obesity and mood disorders

Lhamyani Said , Clemente Mercedes , Gentile Adriana , Chacón Pedro , Javier Pavón Francisco , José Tinahones Francisco , Olveira Gabriel , El Bekay Rajaa

Background and aim: Obesity (Ob) is tightly associated with metabolic diseases such as type 2 diabetes (DT2) andinsulin resistance (IR). Furthermore, obesity has been identified as one of the primary causes of mood disorders (MDs) including depression. Several studies have demonstrated the link between Ob, adiposity, neuroinflammation and MDs. The Brain-Derived Neurotrophic Factor (BDNF) and its regulator, the non-coding RNA BDNF antisense RNA (BDNFas), play an import...

ea0073ep52 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The association of depression with adipose tissue inflammation related to obesity

Lhamyani Said , Mariel Gentile Adriana , Maria Isabel Cabrera Gonzalez , Sanchez Marin Laura , Serrano Antonia , Francisco José Tinahones , Olveira Gabriel , El Bekay Rajaa

Background and aimMajor depressive disorder (MDD) is one of the common mental disorder that affect more than 350 million subjects. MDD has been reported to be associated with systemic inflammation and obesity. However, there are no data that relate adipose tissue (AT) inflammation to MDD. The analysis of inflammatory markers in AT could pave the way to clarify the potential association between MDD and obesity. For this reason, the aim of our study was to...