Searchable abstracts of presentations at key conferences in endocrinology

ea0011p152 | Clinical case reports | ECE2006

Secondary amenorrhoea induced by dihydrocodeine ingestion resolves following opiate withdrawal

González S , Murray RD

Objective: Diamorphine and methadone administration are associated with dysfunction of the hypothalamo pituitary gonadal axis in premenopausal women. However, the effects of less potent opioids on this axis remain unclear.Methods: We report a case of a 42 year old woman referred with secondary amenorrhoea and low oestradiol levels (oestradiol <50 iu/l). She started menarche aged 14, followed by regular menstrual cycles, two successful pregnancies, tw...

ea0011p573 | Growth and development | ECE2006

Double blind placebo controlled study on the impact of RGH replacement on quality of life in patients with severe growth hormone deficiency

González S , Sugunendran S , Atkin SL

Objectives: Conflicting data of the benefits of GH replacement improving psychological and physical well being is available, though open GH studies generally agree on an overall improvement. For growth hormone deficient patients to continue on therapy after evaluation there should be a 7 point improvement in their QoL-AGHDA, as documented in the NICE guidelines. The aim of this study was to determine the impact of 0.4 mg of GH on QoL in severe GH deficient patients in a double...

ea0011p279 | Diabetes, metabolism and cardiovascular | ECE2006

Des-acyl ghrelin regulates glucose and lipid metabolism in HL-1 cardiomyocytes

Iglesias MJ , Piñeiro R , Eiras S , Rodiño B , González-Juanatey JR , Lago MF

Background: Des-acyl ghrelin (Des-G) is an isoform of ghrelin without the n-octanoyl modification at Ser3 present in this peptide. It is mainly produced in endocrine cells located in the stomach, in the mucosal layer of the fundus, and it is secreted into bloodstream where it circulates in higher amounts than ghrelin (2:1).Although Des-G was previously thought of as a non-functional peptide, since it does not activate GHS-R1a, recent studies have shown t...

ea0073aep685 | Thyroid | ECE2021

Iodized salt is sufficient to obtain an adequate nutritional status of iodine in pregnant woman

Silvia González Martínez , Ana Isabel Escudero Gomis , Delgado Elias , Edelmiro Luis Menendez Torre

IntroductionIodine is an essential micronutrient used by the thyroid gland to produce thyroid hormones. Iodine deficiency during pregnancy is related to impaired neurocognitive development of fetus and neonate. The WHO recommends iodization of salt as main measure to prevent iodine deficiency disorders. In pregnant population other international organizations recommend the use of iodine supplements to guarantee adequate nutritional status of iodine (medi...

ea0070aep36 | Adrenal and Cardiovascular Endocrinology | ECE2020

Identification of the genetic signature of vascular calcification in patients with type 2 diabetes mellitus by a computational approach

Andújar-Vera Francisco , García-Fontana Cristina , González-Salvatierra Sheila , Muñoz-Torres Manuel , García-Fontana Beatriz

Introduction: The analysis of the signaling pathways involved in vascular calcification is difficult due largely to the limitation in obtaining vascular tissue samples. Therefore, the use of bioinformatics tools for the identification of potential biomarkers associated with vascular calcification is an advantage for the advancement in the knowledge of the molecular pathways involved in this pathology.Objective: Increase understanding of the molecular mec...

ea0070aep457 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Real-life clinical experience with GLP1 analogs and SGLT2 inhibitors in the treatment of diabetes type 2 and obesity

Pérez-Rodríguez José , Calderón-Vicente Dulce , González-López Javier , Martín-Iglesias David , Alramadan Mubarak

Objectives: SGLT2 inhibitors and GLP1 analogs are the treatment of choice after metformin in patients with type 2 diabetes (DM2) and overweight-obesity (OB). The aim of this study is to analyze the effectiveness and safety of these treatments alone or in combination.Methodology: This is a retrospective observational study in the usual clinical practice. We analyzed the effects of SGLT2 inhibitors and GLP1 analogs treatments in patients with DM2 and OB wh...

ea0073pep15.5 | Presented ePosters 15: Late Breaking | ECE2021

Pheochromocytoma secreting IL-6; an atypical presentation

Laura García María , Lisdero Ana Paula , González Pernas Mariana , Speroni Romina , Segarra Ana , Otero Jimena , Genovesi Elbio , Belli Susana , Giselle Mumbach Aizhar

Pheochromocytoma (PCC) is a rare tumor that arises from the adrenal medulla, usually presents with headache, sweating and palpitations due to excessive catecholamine release. However, PCC may secrete neuropeptides, hormones and cytokines, such as interleukin-6 (IL-6)) resulting in unusual clinical manifestations. A 48-year-old woman with a previous history of type 1 neurofibromatosis (NF1) and hypertension was referred to discarded PCC. Laboratory tests revealed leukocytosis a...

ea0073aep760 | Thyroid | ECE2021

Graves’ Disease after COVID-19

Moreno Tirado Antonio , Paloma González Lázaro , Contreras Pascual Cristina , Montalban Mendez Cristina , Maria Zhao Montero Benítez , Florentino Del Val Zaballos

IntroductionGraves’ Disease is an autoimmune syndrome that include hyperthyroidism, goiter, thyroid eye disease, and occasionally, a dermopathy called pretibial or localized myxedema. As each autoinmune ailment to develop in sufferers with genetic susceptibility after a certain environmental exposure (infection, stress…). COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Since the out...

ea0070aep466 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effectiveness of PCSK9 inhibitors in familial hypercholesterolemia in asturias, spain

González Martínez Silvia , Rodriguez Escobedo Raul , Luis Fernández Morera Juan , José López Alba Alfonso , Antonio Álvarez Tamargo José , José Lamela Piteira Carlos , Villazón González Francisco

Introduction: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of LDL cholesterol (LDL-C) from birth. Treatment with statins and ezetimibe achieves in most cases large reductions in LDL-C. In those patients in whom the reduction in LDL-C is insufficient or who have intolerance to such treatments, the appearance of PCSK9 inhibitors has been an effective and safe alternative to achieve the LDL-C objectives.Materials and...

ea0070ep170 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of liver fibrosis in patients with diabesity

González Arnáiz Elena , Pintor De la Maza Begoña , González Roza Lucía , Ramos Bachiller Beatriz , Quiñones Castro Raisa , Ariadel Cobo Diana , Barajas Galindo David , Fondo Ana Urioste , Ballesteros Pomar María , Cano Rodriguez Isidoro

Background: NAFLD(non–alcoholic fatty liver disease) includes; non–alcoholic fatty liver(NAFL), non–alcoholic steatohepatitis (NASH) and its complications (fibrosis, cirrhosis and hepatocellular carcinoma). These diseases are currently the most common cause of liver disease in western countries, due to the obesity and DM2 epidemic. There are scores that determine the risk of liver fibrosis in a non–invasive way.Aims: To determine ...