Endocrine Abstracts

Context: Evidence suggests that gabapentin, a γ-aminobutyric acid analogue, is effective in the treatment of hot flushes in women with natural or tamoxifen-induced menopause.Objective and design: To investigate the efficacy and tolerability of gabapentin for the treatment of menopausal hot flushes, a systematic review of all pertinent trials and a meta-analysis of those that were randomized placebo-controlled (RCT) were performed.<p class="abste...

Traditionally, male hypogonadism is classified into hypogonadotrophic (the archetype being Kallmann syndrome) and hypergonadotrophic (the archetype being Klinefelter syndrome). Late-onset hypogonadism (LOH) constitutes a separate entity that can be defined as the state where men of advanced age demonstrate low serum testosterone (T) concentrations in combination with a spectrum of symptoms reminiscent of those of ‘classic’ male hypogonadism (e.g. reduced sexual funct...

Aim: Infertility, defined as the non-achievement of pregnancy by a couple after 12 months of free sexual intercourse, affects 4 - 17% of couples worlwide. In 20% of cases, the cause is found exclusively or mainly in the man. The purpose of this study is to evaluate infertility as a risk factor for increased psychological stress.Material and Methods: A case – control study was conducted in which the levels of psychological stress of men with infertil...

Background and aim: Low energy availability (LEA) may lead to menstrual disorders and low bone mineral density, predisposing to the female athlete triad (FAT) syndrome. The primary aim of this review was to systematically investigate the impact of sports on the energy status of professional female athletes compared to sedentary, recreationally active controls, with regard to their menstrual status and bone mineral density (BMD). A secondary aim was the estimation of the combin...

Introduction: The maximum period of bisphosphonate use has not been determined, as their long-term appliance has been associated with adverse effects, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF).The aim of this study was to systematically present existent data regarding the effect of bisphosphonate discontinuation on fracture risk and bone mineral density (BMD).Methods/design: MEDLINE, Scopus, EMBASE...

Background and Objective: Although several epidemiological studies have been conducted, the impact of Follicle Stimulating Hormone Receptor (FSHR) polymorphisms on male infertility remains unclear. The aim of this study was to investigate the prevalence of specific FSHR Single Nucleotide Polymorphisms (SNPs) in the Greek population and associate the latter with the clinical phenotype.Patients and Methods: We enrolled 96 subjects: men with idiopathic non-...

Introduction: Discontinuation of denosumab may rarely lead to rebound fractures, although the evidence is low, since available data have derived from case reports and post-hoc analyses.Case presentation: A 45-year old Caucasian male was presented at the outpatient clinic in February 2016 for evaluation and management of severe osteoporosis, which had been complicated with multiple vertebral low energy fractures at the 10 th to 12th ...

Purpose: Androgens promote early follicular development and granulosa cell proliferation by augmenting follicle-stimulating hormone (FSH) receptor expression in granulosa cells. Several retrospective studies have evaluated the association between basal androgen concentrations and follicular development in women undergoing ovarian stimulation for in vitro fertilization (IVF) with conflicting results. The aim of this study was to investigate whether basal androgen concentrations...

Objective: To systematically review and meta-analyze the best available evidence regarding the effect of vitamin D supplementation, either as monotherapy or in combination with protein and exercise, on sarcopenia indices (muscle strength, muscle mass, muscle performance).Materials and methods: A comprehensive search was conducted in Medline, Cochrane Central, and Scopus databases, up to December 31st, 2018. Data were expressed as standardized ...

Introduction: Lactation-related osteoporosis is a very rare entity, usually diagnosed with one or more fractures, during the early postpartum period. Due to the rarity of this condition, no consensus still exists with regard to thetype and optimal duration of treatment.Case presentation: A 39-year old Caucasian female was presented at the outpatient clinic in December 2016 for evaluation and management of severely low bone mineral density (BMD) and multi...