Endocrine Abstracts

Purpose: The postoperative levels of cortisol and ACTH are the most commonly used markers for the prediction of Cushing’s disease (CD) remission after transsphenoidal surgery (TSS). However, there is still no consensus on the collection time and threshold values of basal cortisol and ACTH levels after surgery to predict remission of CD.Aim: To study the significance of early postoperative serum cortisol and plasma ACTH testing in the prognosis of C...

In several studies, the state of the endothelial function is analyzed in clinical thyrotoxicosis. Increased level of von Willebrand factor is detected. Many events of association of trombosis at these patients with high level of VWF are described. An association between autoimmune thyroid disease and pulmonary arterial hypertension (PAH) has been reported too. We have studied factors which influence on level of VWF at patients with a clinical thyrotoxicosis of a various genesi...

Thyroid disease is associated with atherosclerosis cardiovascular disease. This is undoubted for overt hypothyroidism, but is controversy in subclinical hypothyroidism hittle is known about the relationship between insulin resistance and thyroid function. It is well known that insulin resistance is the main part of metabolic syndrome. We aimed to investigate the relationship between thyroid function, body mass index (BMI) and homeostasis model assessment index for insulin resi...

Subclinical hypothyroidism (SH) is very frequent condition in older population. If can occur in 12–20% of patients older than 60. It is well known today that thyroid hormones can increase gene expression of APO-B receptors in the liver and by this way improve catabolism of atherogenic lipoproteins. They also can regulate processes of contractility and weakening of heart muscle. Decrease of cardiac output and diastolic disfunction of left ventricle can be revealed in SH pa...

Subclinical thyrotoxicosis (ST) characterized by low serum TSH and normal FT4 and FT3 concentrations. ST may cause changes of geometry of heart and developments of diastolic dysfunction. Influence of ST on this evolutions depending on age of patients, duration of S?, effect of TSH level is not clear. In present research the effects of ST on changes of EchoCG at a different age were studied. The present study includes 66 normotensive patients with ST witho...

Introduction: Nivolumab, an anti–programmed cell death-1 (PD-1) monoclonal antibody, is a promising treatment of variety advanced malignancies. Immune checkpoint inhibitors can cause immune-related adverse events, including endocrine pathology. Destructive thyroiditis is one of the most frequently observed nivolumab-induced endocrine irAEs which associated with the presence of anti–thyroid peroxidase antibodies (TPO-Abs) and anti-thyroglobulin antibodies (Tg-Abs) pri...

Backgraund: Insulinoma is the most common functional pancreatic neuroendocrine tumor originating from β-cells, with unregulated insulin production and rarely associated with MEN-I syndrome. Diagnosis and treatment of insulinoma are a challenge in the practice of endocrinologist.Aim: To determine on the basis of retrospective analysis the optimal approaches to the management of patients with organic hyperinsulinism.Materials an...

Purpose: Primary hyperparathyroidism (PHPT) is the third common endocrine disorder which often manifest with skeletal or renal disfunction. In developed countries asymptomatic form is the most common and such severe manifestations as osteofibrosis cystica are very rare.Clinical case: We present the case of 49-years-75 × 66 old caucasian woman, with history of urolithiasis, nephrolithotripsy in 2014. In November 2016 she was diagnosed with left femur...

Accumulating facts show that incretin-modulating therapy could be beneficial in both glycemic control and nephroprotection in type 2 diabetes (DM2). Clinical evidence for nephroprotective potential of DPP-4 inhibitors is limited and predictive determinants are unknown. The study conducted with DM2 patients aimed to assess renal effects of vildagliptin addition and identify their clinical and laboratory predictors. The study enrolled 44 insulin-treated male and female type 2 di...

PurposePostoperative central diabetes insipidus (PCDI) is one of the complications of transsfenoidal adenomectomy (TSA) in patients with Cushing’s disease. Identification of predictors of PCDI development and clinical course could optimize the management of such patients.AimTo study the prevalence of PCDI in patients with Cushing’s disease after transsphenoidal adenomectomy and to find the risk fact...