Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep651 | Pituitary and Neuroendocrinology | ECE2020

Predictors of Cushing’s disease remission after transsphenoidal endoscopic surgery

Kuritsyna Natalia , Tsoy Uliana , Cherebillo Vladislav , Paltsev Artem , Tsiberkin Alexandr , Vasilieva Elena , Grineva Elena

Purpose: The postoperative levels of cortisol and ACTH are the most commonly used markers for the prediction of Cushing’s disease (CD) remission after transsphenoidal surgery (TSS). However, there is still no consensus on the collection time and threshold values of basal cortisol and ACTH levels after surgery to predict remission of CD.Aim: To study the significance of early postoperative serum cortisol and plasma ACTH testing in the prognosis of C...

ea0016p720 | Thyroid | ECE2008

Level of von Willebrand factor in thyrotoxicosis of a various genesis

Babenko Alina , Cadinskaya Margarita , Grineva Elena

In several studies, the state of the endothelial function is analyzed in clinical thyrotoxicosis. Increased level of von Willebrand factor is detected. Many events of association of trombosis at these patients with high level of VWF are described. An association between autoimmune thyroid disease and pulmonary arterial hypertension (PAH) has been reported too. We have studied factors which influence on level of VWF at patients with a clinical thyrotoxicosis of a various genesi...

ea0016p779 | Thyroid | ECE2008

Thyroid function is associated with insulin sensibility

Volkova Anna , Grineva Elena , Dora Svetlana

Thyroid disease is associated with atherosclerosis cardiovascular disease. This is undoubted for overt hypothyroidism, but is controversy in subclinical hypothyroidism hittle is known about the relationship between insulin resistance and thyroid function. It is well known that insulin resistance is the main part of metabolic syndrome. We aimed to investigate the relationship between thyroid function, body mass index (BMI) and homeostasis model assessment index for insulin resi...

ea0016p780 | Thyroid | ECE2008

Severity of coronary atherosclerosis in patients with different TSH levels

Volkova Anna , Grineva Elena , Dora Svetlana

Subclinical hypothyroidism (SH) is very frequent condition in older population. If can occur in 12–20% of patients older than 60. It is well known today that thyroid hormones can increase gene expression of APO-B receptors in the liver and by this way improve catabolism of atherogenic lipoproteins. They also can regulate processes of contractility and weakening of heart muscle. Decrease of cardiac output and diastolic disfunction of left ventricle can be revealed in SH pa...

ea0014p322 | (1) | ECE2007

Influence of a subclinical thyrotoxicosis on heart in various age-grades

Babenko Alina , Grineva Elena , Vashrameeva Natalia

Subclinical thyrotoxicosis (ST) characterized by low serum TSH and normal FT4 and FT3 concentrations. ST may cause changes of geometry of heart and developments of diastolic dysfunction. Influence of ST on this evolutions depending on age of patients, duration of S?, effect of TSH level is not clear. In present research the effects of ST on changes of EchoCG at a different age were studied. The present study includes 66 normotensive patients with ST witho...

ea0063p758 | Thyroid 2 | ECE2019

Nivolumab-induced hypothyroidism in young male without prior antithyroid autoimmunity

Tsiberkin Alexander , Kuritsyna Natalia , Klyaus Nataliya , Tsoy Uliana , Grineva Elena

Introduction: Nivolumab, an anti–programmed cell death-1 (PD-1) monoclonal antibody, is a promising treatment of variety advanced malignancies. Immune checkpoint inhibitors can cause immune-related adverse events, including endocrine pathology. Destructive thyroiditis is one of the most frequently observed nivolumab-induced endocrine irAEs which associated with the presence of anti–thyroid peroxidase antibodies (TPO-Abs) and anti-thyroglobulin antibodies (Tg-Abs) pri...

ea0049ep200 | Neuroendocrinology | ECE2017

Insulinoma: diagnostic features and treatment management

Khacimova Liana , Karonova Tatiana , Tsoy Uliana , Ianevskaia Liubov , Grineva Elena

Backgraund: Insulinoma is the most common functional pancreatic neuroendocrine tumor originating from β-cells, with unregulated insulin production and rarely associated with MEN-I syndrome. Diagnosis and treatment of insulinoma are a challenge in the practice of endocrinologist.Aim: To determine on the basis of retrospective analysis the optimal approaches to the management of patients with organic hyperinsulinism.Materials an...

ea0070ep109 | Bone and Calcium | ECE2020

Hip fracture and the brown tumors as clinical manifestation of primary hyperparathyroidism in late reproductive age woman: Case report.

Yanevskaya Liubov , Karonova Tatiana , Pogosian Karina , Ryzhkova Daria , Grineva Elena

Purpose: Primary hyperparathyroidism (PHPT) is the third common endocrine disorder which often manifest with skeletal or renal disfunction. In developed countries asymptomatic form is the most common and such severe manifestations as osteofibrosis cystica are very rare.Clinical case: We present the case of 49-years-75 × 66 old caucasian woman, with history of urolithiasis, nephrolithotripsy in 2014. In November 2016 she was diagnosed with left femur...

ea0056p471 | Diabetes complications | ECE2018

Clinical and laboratory predictors of positive renal effects of vildagliptin

Bayrasheva Valentina , Pchelin Ivan , Babenko Alina , Chefu Svetlana , Grineva Elena

Accumulating facts show that incretin-modulating therapy could be beneficial in both glycemic control and nephroprotection in type 2 diabetes (DM2). Clinical evidence for nephroprotective potential of DPP-4 inhibitors is limited and predictive determinants are unknown. The study conducted with DM2 patients aimed to assess renal effects of vildagliptin addition and identify their clinical and laboratory predictors. The study enrolled 44 insulin-treated male and female type 2 di...

ea0073aep545 | Pituitary and Neuroendocrinology | ECE2021

Postoperative central diabetes insipidus after transsphenoidal adenomectomy in patients with Cushing’s disease

Tsoy Uliana , Bolatova Aizanat , Cherebillo Vladislav , Grineva Elena

PurposePostoperative central diabetes insipidus (PCDI) is one of the complications of transsfenoidal adenomectomy (TSA) in patients with Cushing’s disease. Identification of predictors of PCDI development and clinical course could optimize the management of such patients.AimTo study the prevalence of PCDI in patients with Cushing’s disease after transsphenoidal adenomectomy and to find the risk fact...