Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep854 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of cystic prolactinoma responsed to medical treatment

Omma Tulay , Gulcelik Nese Ersoz , Karaca Anara , Taskaldiran Isilay

Introduction: Cystic prolactinomas are considered resistant to volume depletion by dopamine agonists (DAs). Because of the effectiveness and tolerability, dopamine agonists (DAs) are the first line therapies in prolactinoma and reduce tumor mass as well as prolactin levels in most of all patients. Rathke’s cleft cysts, craniopharyngiomas and arachnoid cysts are differential diagnoses to keep in mind. DAs resistance or intolerance, psychiatric disorders associated with dop...

ea0049ep344 | Endocrine tumours and neoplasia | ECE2017

Differential roles of carboxylated and uncarboxylated Osteocalcin in stage I breast cancer as a diagnostic biomarker

Karaca Anara , Gulcelik Nese Ersoz , Bakar Filiz , Akgul Giray , Sahiner Zeynep , Gulcelik Mehmet Ali

Objective: The finding of new biomarkers is needed to have an early diagnosis of breast cancer. In this study we evaluated serum levels of carboxylated osteocalcin (OC) and uncarboxylated osteocalcin(UcOC), CRP as a diagnostic biomarker for breast cancer.Design and methods: Blood samples of 39 women with newly diagnosed breast cancer with stage I were obtained before surgery and 39 age and BMI matched health women were selected as controls.<p class="...

ea0049ep384 | Clinical case reports - Pituitary/Adrenal | ECE2017

Prediction of type 1 diabetes in autoimmune polyglandular syndrome type 2

Karaca Anara , Gulcelik Nese Ersoz , Omma Tulay , Taskaldiran Isilay , Firat Sevde Nur , Bozkurt Nujen

Introduction: Autoimmune Polyglandular Syndrome (APS) is a very rare endocrinopaty, characterized by the coexistence of at least two glandular autoimmune mediated diseases. In this case a patient presented with hyperpigmentation of the whole body, significant weight loss for last 6 months.Case: A-49 year old male were refered to our deparment with loss of appetite, fatigue, nausea, weight loss and with marked buccal pigmentation. Blood pressure was 80/50...

ea0035p385 | Diabetes (epidemiology, pathophysiology) | ECE2014

Presence of erythrocytosis in a patient with concomitant type 1 diabetes mellitus and Gitelman syndrome

Keskin Muge , Ozcan Muge , Aydin Unsal , Culha Cavit , Koc Gonul , Aral Yalcin , Gulcelik Nese Ersoz

İntroduction: Gitelman syndrome is characterized with hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis and neurological symptoms like muscle weakness. The association of GS and type 1 diabetes is rare, only described in a few case reports. We report a patient with unusual combination of Gitelman syndrome, Type 1 Diabetes Mellitus whose presentation was erytrocytosis.Case: A 26-year old male was diagnosed as Gitelman’s syndrome 5...

ea0026p444 | Thyroid (non cancer) | ECE2011

Regulation of visceral adipose tissue-derived serin protease inhibitor in overt and subclinical hypothyroid patients

Cinar Nese , Gulcelik Nese Ersoz , Aydin Kadriye , Akin Safak , Usman Aydan , Gurlek Alper

Introduction: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine which might exert an insulin-sensitizing effect. It is thought that vaspin mRNA expression may be a compensatory mechanism associated with obesity and insulin resistance. Given the fact that subclinical and overt hypothyroidism are known risk factors for insulin resistance, we aimed to assess the regulation of vaspin by thyroid hormones in humans.Met...

ea0022p351 | Diabetes | ECE2010

Increased serum nesfatin-1 levels in patients with impaired glucose tolerance

Gulcelik Nese Ersoz , Akin Safak Cavus , Aksoy Duygu Yazgan , Karakaya Jale , Usman Aydan

Objective: Nesfatin was found to be co-localized with insulin in pancreatic β cells and its levels were decreased in type 2 diabetic patients. In order to investigate the role of nesfatin in carbohydrate metabolism, we measured baseline nesfatin-1 levels and its response to glucose load in patients with impaired glucose tolerance (IGT) and in healthy subjects.Subjects and methods: Fourteen patients with IGT and, 13 age and body mass index matched co...

ea0022p810 | Thyroid | ECE2010

Atorvastatin inhibited proliferation in papillary thyroid cancer cell line

Gulcelik Nese Ersoz , Zeybek Dilara , Kaymaz Figen , Sarisozen Can , Asan Esin , Vural Imran , Usman Aydan

Aim: The role of statins on thyroid cell proliferation is of clinical interest. In this study, we investigated the effect of atorvastatin on papillary thyroid cell line (B-CPAP) and normal thyroid (Nthy-ori3-1) cell lines.Materials and methods: In this in vitro study, B-CPAP and Nthy-ori3-1 cell lines were treated with atorvastatin at 12.5, 25, 50, 100, 200 μM concentrations. At 48 and 72 h MTT, electron microscopy and immunohistochemistry we...

ea0056ep92 | Interdisciplinary endocrinology | ECE2018

FGF21 levels in patients with breast cancer

Sahiner Zeynep , Karaca Anara , Bakar Filiz , Akgul Giray , Ali Gulcelik Mehmet , Gulcelik Nese Ersoz

Aim: FGF-21, is a member of the FGF family that is involved in biological processes such as embryonic development, cellular growth, morphogenesis, tissue repair, tumor growth and invasion, with mitogenic and cellular vital activity activity in the cytogenetic localization of 19q13.33. Breast cancer is the fatal disease most commonly seen in women and increasing in frequency and the relationship between hormones secreted from adipose tissue and some cancers has been shown in re...

ea0073oc10.1 | Oral Communications 10: Thyroid | ECE2021

The role of VEGF expression in the development of papillary thyroid carcinoma in patients with lymphocytic thyroiditis

Gulcelik Nese Ersoz , Akın Şafak , Aydin Kadriye , Aydin Mericö Cisel , Usman Aydan

BackgroundVascular endothelial growth factor (VEGF) has been implicated in angiogenesis of papillary thyroid carcinoma (PTC). As VEGF expression is increased in PTC and even in lymphocytic thyroiditis (LT), we hypothesized that VEGF may play a role in the development of PTC in patients with LT. In order to find an association between VEGF and these disorders, we examined both the tumoral and adjacent tissues of PTC patients with and without LT.<p cla...

ea0056p566 | Obesity | ECE2018

Does follicle stimulating hormone effect adiposity in patients with hypergonadotrophic hypogonadism: a retrospective study

Demirci Ibrahim , Haymana Cem , Gulcelik Nese Ersoz , Sonmez Yusuf Alper , Meric Coskun , Aydogdu Aydogan , Demir Orhan , Azal Omer

Introduction: Recent studies showed that post-menopausal osteoporosis and weight gain starts at the perimenopause stage, a period characterized by relatively stable estrogen and rising FSH levels. FSH is found to be associated with adiposity in women, which is also a great risk factor for type 2 DM. There is also a sharp increase in visceral adiposity during this life stage, which coincides with the emergence of disrupted energy balance and reduced physical activity. There is ...