Searchable abstracts of presentations at key conferences in endocrinology

ea0011s93 | Contrasting practices in European endocrinology | ECE2006

Contrasting practices in European endocrinology. Radioiodine therapy. A Danish view

Hegedüs L

Radioiodine (131-I)- in use for more than 50 years for hyperthyroidism, with or without goitre, and also more recently for non-toxic goitre- has proven effective in the treatment of hyperthyroidism as well as in reducing goitre size. In hyperthyroidism, one or two 131-I doses will cure nearly all patients. Factors such as: sex, age, morphological goitre type, size of goitre, presence of thyroid autoantibodies, and pre- and post-radioiodine antithyroid drug (ATD) therapy influe...

ea0014p360 | (1) | ECE2007

Do patients and clinicians agree about which aspects of quality of life are relevant when evaluating the impact of thyroid diseases?

Watt Torquil , Hegedüs Laszlo , Rasmussen Æse Krogh , Groenvold Mogens , Bonnema Steen Joop , Bjorner Jakob , Feldt-Rasmussen Ulla

Objective: During the development of a thyroid-specific quality of life (QoL) questionnaire, patients and clinicians rated the relative relevance of a list of possibly relevant QoL issues. In this study we compare the patient and clinician ratings.Methods: Fifteen thyroid experts and 80 thyroid outpatients (14 with non-toxic goitre, 12 nodular toxic goitre, 21 Graves’ disease, 17 thyroid associated ophthalmopathy (TAO) and 16 primary hypothyroidism)...

ea0011p848 | Thyroid | ECE2006

Towards the development of a valid quality of life questionnaire for patients with thyroid diseases: Which questions shall we ask?

Watt T , Groenvold M , Rasmussen AK , Bonnema SJ , Hegedüs L , Bjorner JB , Feldt-Rasmussen U

Background and aim: In clinical populations, generic quality of life (QoL) questionnaires should be supplemented with disease-specific questionnaires, which may have higher sensitivity and clinical relevance. For the purpose of developing a comprehensive thyroid QoL questionnaire, we have evaluated the relative importance of various QoL aspects to thyroid patients.Methods: A list of problems (issues) related to thyroid diseases, previously identified thr...

ea0070aep875 | Thyroid | ECE2020

Treatment of hyperthyroidism reduces the systemic oxidative stress load, as measured by biomarkers of RNA and DNA damages

Larsen Camilla , Ryom Riis Kamilla , Hillert Winter Kristian , List Larsen Emil , Ellervik Christina , Hegedüs Laszlo , Brix Thomas , Enghusen Poulsen Henrik , Joop Bonnema Steen

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abst...

ea0070ep516 | Thyroid | ECE2020

Treatment of hypothyroidism does not affect whole-body oxidative stress, as measured by biomarkers of RNA and DNA damage

Ryom Riis Kamilla , Larsen Camilla , Winther Kristian H. , Larsen Emil L. , Ellervik Christina , Hegedüs Laszlo , Brix Thomas , Poulsen Henrik E. , Bonnema Steen J.

Background: Hyperthyroidism as well as hypothyroidism have been associated with oxidative stress, caused by an imbalance between pro-oxidants and antioxidants. Oxidative stress may damage the genomic apparatus and other cellular structures. Urinary excretion of 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent global RNA and DNA oxidation, thus reflecting oxidatively generated modification of nucleic acids in...

ea0073oc5.2 | Oral Communications 5: Thyroid | ECE2021

Use of thyroid hormones in hypothyroid and euthyroid patients: A 2020 THESIS* questionnaire survey of members of the Danish Endocrine Society (*Treatment of hypothyroidism in europe by specialists: An international survey)

Riis Kamilla Ryom , Froelich Jacob , Hegedüs Laszlo , Negro Roberto , Attanasio Roberto , Nagy Endre , Papini Enrico , Perros Petros , Bonnema Steen J.

PurposeThe standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients.MethodAn e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all me...

ea0073aep733 | Thyroid | ECE2021

Endocrinologists’ choice of levothyroxine formulation in hypothyroid and euthyroid patients in the republic of belarus

Shepelkevich Alla , Dydyshka Yuliya , Yurenia Alena , Lobashova Veranika , Attanasio Roberto , Laszlo Hegedüs , Nagy Endre , Negro Roberto , Papini Enrico , Perros Petros

Background and aimsIn the Republic of Belarus treatment of hypothyroidism in the adult population is regulated by the order of the Ministry of Health dated 2013. Levothyroxine is available in tablet form (dosage in increments of 25 µg). Liothyronine are not registered in the Republic of Belarus, but patients can purchase them on their own abroad. Thus, the aim was to study of possible endocrinologists’ preferences of choosing the levothyroxine ...

ea0073aep734 | Thyroid | ECE2021

Possible causes of hypothyroidism symptoms in euthyroid patients - an endocrinologist opinion study in the republic of belarus

Dydyshka Yuliya , Shepelkevich Alla , Yurenia Alena , Elena Brutskaya-Stempkovskaya , Attanasio Roberto , Laszlo Hegedüs , Nagy Endre , Negro Roberto , Papini Enrico , Perros Petros

Background and aimsIt has been reported that some patients with hypothyroidism treated with levothyroxine continue to experience persistent symptoms despite normal serum TSH. Thus, the aim was to study of causes of hypothyroidism symptoms in euthyroid patients.Materials and methodsFrom 01.10.2020 to 26.12.2020 there was survey using THESIS questionnaire: Treatment of Hypothyroidism in Europe by Specialists: I...