Searchable abstracts of presentations at key conferences in endocrinology

ea0081p367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metformine: anti-fibrotic molecule?

Khelifi Dayssem , Ben Nacef Ibtissem , Bouzid Kahena , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Background and aims: Diabetes causes tissue fibrosis by still poorly understood mechanisms which involve glycation products. Galectin-3 (Gal-3) is an emerging key player in metabolic disorders and a powerful factor in the development and progression of the fibrotic process in target organs in diabetic patients. The plasma level of Gal-3 increases during diabetic cardiomyopathy and diabetic nephropathy. We have studied the correlation between serum Gal-3 level and anti-diabetic...

ea0081p374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Threshold value of galectine-3 in a Tunisian diabetic population

Khelifi Dayssem , Nacef Ibtissem Ben , Bouzid Kahena , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Background and aims: Plasma Galectin-3 (Gal-3), mediator of fibrogenesis and inflammation, has been implicated in many diseases. Particularly in diabetics, this lectin directly mediates transdifferentiation in collagen-producing cells thus leading to fibrosis of target organs and accelerating the development of complications. The objective of our study was to determine a cut-off value for Gal-3 in our population.Methods: We conducted a cross-sectional, a...

ea0081ep95 | Adrenal and Cardiovascular Endocrinology | ECE2022

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency and hypertension: a case report

Besrour Chayma , Imen Rojbi , Sabrine Mekni , Marwa Majdoub , Youssef Lakhoua , Ibtissem Ben Nacef , Karima Khiari

Introduction: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common of the CAH, it is also the most common of the autosomal recessive diseases. Hypertension is generally absent, and its presence should lead to an investigation of another cause.Observation: We report the case of a 26-year-old young man, descendant from a second-degree consanguineous marriage with a family history of the death of a brother at the age of 2...

ea0081ep178 | Calcium and Bone | ECE2022

Sickle cell disease and hyperparathyroidism: case report

Jridi Maysam , Mekni Sabrine , Meriem Adel , Rojbi Imen , Nacef Ibtissem Ben , Mchirgui Nadia , Khiari Karima

Introduction: Primary hyperparathyroidism (pHPT) is a common endocrine disorder usually diagnosed by the presence of elevated serum calcium levels with inappropriate normal or increased parathyroid hormone (PTH) serum levels. This condition has been reported in few cases of patients with sickle cell disease (SCD), a multisystem disorder with acute and chronic complications.Observation: We report a case of a 63-year-old Tunisian woman with a history of ho...

ea0081ep201 | Calcium and Bone | ECE2022

Chronic asymptomatic hypocalcemia following thyroid surgery

Gharbi Mohamed , Mekni Sabrine , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

Introduction: Postoperative hypoparathyroidism is a frequent complication of total thyroidectomy that must be detected and treated. The resulting hypocalcemia is quite severe and usually occurs in the first few days or weeks after surgery.Herein, we describe a case of chronic asymptomatic hypocalcemia related to postoperative hypoparathyroidism diagnosed years after total thyroidectomy.Observation: We report the case of a 61 year old woman, who had a tot...

ea0081ep235 | Calcium and Bone | ECE2022

Association between primary hyperparathyroidism with severe bone disease and osteomalacia: A case report.

Khiari Hager , Rojbi Imen , Smadhi Houaida , Mekni Sabrine , Lakhoua Youssef , Nacef Ibtissem Ben , Khiari Karima

Introduction: Primary hyperparathyroidism is associated with multiple complications: severe bone disease is one of them. Osteomalacia is by definition a metabolic bone disease characterized by a softening of the bones. We herein report a rare case of an association between primary hyperparathyroidism with osteitis fibrosa cystica and osteomalacia caused by a severe vitamin D deficiency.Observation: A 37-year old woman was referred for investigation of we...

ea0081ep241 | Calcium and Bone | ECE2022

Pseudohypoparathyroidism discovered in adulthood

Besrour Chayma , Imen Rojbi , Sabrine Mekni , Marwa Majdoub , Youssef Lakhoua , Ibtissem Ben Nacef , Karima Khiari

Introduction: Pseudohypoparathyroidism (PHP) is a part of a very rare heterogeneous group of endocrine disorders. It is caused by alterations in the PTH receptor, which is encoded by the GNAS1 gene inducing target tissue resistance to PTH. Pseudohypoparathyroidism typically gets discovered during early childhood, rare are the cases discovered in adulthood.Observation: Herein the case of a 35-year-old man, descendant of a non-consanguineous marriage, with...

ea0081ep245 | Calcium and Bone | ECE2022

A recurrent hypercalcemia after subtotal parathyroidectomy revealing a Munchhausen syndrome

Kamoun Elyes , Nacef Ibtissem Ben , Mekni Sabrine , Lakhoua Youssef , Mchirgui Nadia , Rojbi Imen , Khiari Karima

Introduction: Primary hyperparathyroidism is the most common manifestation of multiple endocrine neoplasia (MEN) type 1, with a frequent involvement of all the parathyroids. In cases where the four glands werenÂ’t resected, a close monitoring should be performed for an early diagnosis of recurrence. Elevated calcium levels with elevated parathormone (PTH) levels in this context makes the physician suspect an adenoma or a hyperplasia of the remaining parathyroid. We herein ...

ea0081ep248 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between pulse wave velocity and cardiovascular risk in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Diabetes increases the risk of high blood pressure, atherosclerosis, coronary heart disease and stroke. Therefore, People with diabetes have an increased cardiovascular risk. Arterial stiffness is a marker of cardiovascular risk and has been shown to have an independent prognostic effect on cardiovascular disease. The aim of this study was to examine the relationship between cardiovascular risk and arterial stiffness in type 2 diabetes.Meth...

ea0081ep249 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evaluation of pulse wave velocity in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Type 2 diabetes is an insidious and progressive disease; accounting for about 90% of all diabetes cases worldwide. Atherosclerosis is a common pathology in diabetes that involves a combination of fatty degeneration (atherosis) and stiffening of the arterial vessels (sclerosis), and the best tool to evaluate the arterial stiffness is the pulse wave velocity. The aim of this study is to evaluate the arterial stiffness in type 2 diabetic patients.<p class="abste...