Endocrine Abstracts

Background and aims: Diabetes causes tissue fibrosis by still poorly understood mechanisms which involve glycation products. Galectin-3 (Gal-3) is an emerging key player in metabolic disorders and a powerful factor in the development and progression of the fibrotic process in target organs in diabetic patients. The plasma level of Gal-3 increases during diabetic cardiomyopathy and diabetic nephropathy. We have studied the correlation between serum Gal-3 level and anti-diabetic...

Background and aims: Plasma Galectin-3 (Gal-3), mediator of fibrogenesis and inflammation, has been implicated in many diseases. Particularly in diabetics, this lectin directly mediates transdifferentiation in collagen-producing cells thus leading to fibrosis of target organs and accelerating the development of complications. The objective of our study was to determine a cut-off value for Gal-3 in our population.Methods: We conducted a cross-sectional, a...

Introduction: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common of the CAH, it is also the most common of the autosomal recessive diseases. Hypertension is generally absent, and its presence should lead to an investigation of another cause.Observation: We report the case of a 26-year-old young man, descendant from a second-degree consanguineous marriage with a family history of the death of a brother at the age of 2...

Introduction: Primary hyperparathyroidism (pHPT) is a common endocrine disorder usually diagnosed by the presence of elevated serum calcium levels with inappropriate normal or increased parathyroid hormone (PTH) serum levels. This condition has been reported in few cases of patients with sickle cell disease (SCD), a multisystem disorder with acute and chronic complications.Observation: We report a case of a 63-year-old Tunisian woman with a history of ho...

Introduction: Postoperative hypoparathyroidism is a frequent complication of total thyroidectomy that must be detected and treated. The resulting hypocalcemia is quite severe and usually occurs in the first few days or weeks after surgery.Herein, we describe a case of chronic asymptomatic hypocalcemia related to postoperative hypoparathyroidism diagnosed years after total thyroidectomy.Observation: We report the case of a 61 year old woman, who had a tot...

Introduction: Primary hyperparathyroidism is associated with multiple complications: severe bone disease is one of them. Osteomalacia is by definition a metabolic bone disease characterized by a softening of the bones. We herein report a rare case of an association between primary hyperparathyroidism with osteitis fibrosa cystica and osteomalacia caused by a severe vitamin D deficiency.Observation: A 37-year old woman was referred for investigation of we...

Introduction: Pseudohypoparathyroidism (PHP) is a part of a very rare heterogeneous group of endocrine disorders. It is caused by alterations in the PTH receptor, which is encoded by the GNAS1 gene inducing target tissue resistance to PTH. Pseudohypoparathyroidism typically gets discovered during early childhood, rare are the cases discovered in adulthood.Observation: Herein the case of a 35-year-old man, descendant of a non-consanguineous marriage, with...

Introduction: Primary hyperparathyroidism is the most common manifestation of multiple endocrine neoplasia (MEN) type 1, with a frequent involvement of all the parathyroids. In cases where the four glands weren’t resected, a close monitoring should be performed for an early diagnosis of recurrence. Elevated calcium levels with elevated parathormone (PTH) levels in this context makes the physician suspect an adenoma or a hyperplasia of the remaining parathyroid. We herein ...

Introduction: Diabetes increases the risk of high blood pressure, atherosclerosis, coronary heart disease and stroke. Therefore, People with diabetes have an increased cardiovascular risk. Arterial stiffness is a marker of cardiovascular risk and has been shown to have an independent prognostic effect on cardiovascular disease. The aim of this study was to examine the relationship between cardiovascular risk and arterial stiffness in type 2 diabetes.Meth...

Introduction: Type 2 diabetes is an insidious and progressive disease; accounting for about 90% of all diabetes cases worldwide. Atherosclerosis is a common pathology in diabetes that involves a combination of fatty degeneration (atherosis) and stiffening of the arterial vessels (sclerosis), and the best tool to evaluate the arterial stiffness is the pulse wave velocity. The aim of this study is to evaluate the arterial stiffness in type 2 diabetic patients.<p class="abste...