Endocrine Abstracts

Introduction: Among all thyroid nodules 3 to 10% are Hürthle cell (HC) neoplasms classified as either HC adenomas or carcinomas. The presence of capsular or vascular invasion is indicative of a HC carcinoma whose incidence has been found to be 5 to 35%. Hürthle cell carcinoma could also lead to distant metastases and its decreased ability to uptake radioiodine worsens the prognosis. There are reports of histologically characterized HC adenomas with unpredictable clin...

Introduction: Most cases of Diabetes mellitus (DM) in children and adolescents are autoimmune (type 1), even though recently there has been an increase in type 2 DM mainly due to the increased prevalence of obesity in this age group. However, rarely DM could be attributed to other causes such as MODY. An extremely rare cause is the hereditary pancreatitis due to activating mutations of the PRSS1 gene. This gene encodes an enzyme, cationic trypsinogen, whose hyperactivity leads...

Objective: Thyroglobulin (Tg) production by normal or malignant thyroidal cells is TSH dependent. The rhTSH administration for Tg stimulation in patients with differentiated thyroid cancer (DTC), after thyroidectomy and eradication of thyroid remnants with I-131, offers an alternative to thyroid hormone withdrawal preventing the progressive morbidity of hypothyroidism. Tg measurement is usually obtained on the 3rd and 5th day after the first rhTSH injection.<p class="abste...

Forty-one vitamin D deficient women (aged 26-75 years, mean 56.2, median 57) were treated with Vitamin D3 (50000 IU/week for 1.5 month and 25000 IU/week for another 1.5 month). Before treatment their serum 25(OH)D was 17.3&pm;6.1 ng/ml (mean&pm;SD) and after treatment 37.0&pm;7.5 (P<0.0001). Their HOMA-IR was 2.2&pm;1.1 before and 2.3&pm;1.1 after (P=NS), serum insulin 9.0&pm;4.2 mIU/l before and 9.6&pm;4.5 after (NS), glucose 96.2&pm;8.2 mg/dl before and...

Introduction: Patients with primary hyperparathyroidism (PHPT) present high calcium and PTH levels while some patients present also high PTH levels but normal calcium levels (NHPT) and such patients be considered as having normocalcemic hyperparathyroidism. On the other hand vitamin D deficient patients develop secondary hyperparathyroidism (SHPT). Sometimes normocalcemic- and secondary hyperparathyroidism coexist. Therefore in clinical settings it is very difficult to disting...

Aim: To evaluate the change in PFI (Parathyroid Function Index) and WI (Wisconsin Index) after loading with vitamin D in patients with vitamin D deficiency.Patients and Methods: In 41 vitamin D deficient patients (25(OH)2D<17.16&pm;6.07 ng/ml, mean&pm;SD) the PFI (PTHxCa devided by P) and the WI (PTHxCa) were evaluated before and after 3 month loading with Vitamin D 50.000 IU per week for the first 6 weeks and 25.000 IU per week for the ne...

Introduction: Several markers based on anthropometric and biochemical parameters like fatty liver index (FLI), lipid accumulation product (LAP) index and visceral adiposity index (VAI), have been proposed for the detection of nonalcoholic fatty liver disease (NAFLD).Objective: To evaluate the diagnostic performance of FLI, LAP and VAI as markers of NAFLD in premenopausal women with and without polycystic ovary syndrome (PCOS), assessed for hepatic steato...

Introduction: Several studies have demonstrated associations of birth weight with metabolic and reproductive abnormalities in adults. The aim of this study was to investigate the birth weight in women with PCOS and its correlation with important clinical and biochemical parameters of the syndrome.Patients and methods: We studied 288 women with PCOS according to the NIH criteria (1990) and 166 women with normal cycles and without clinical or biochemical h...

Background: Subclinical autonomous cortisol hypersecretion is the most common hormonal abnormality in patients with adrenal incidentalomas, which is characterized by subtle abnormalities of the hypothalamic–pituitary–adrenal axis (HPA) due to adrenal autonomy. Possible detrimental effects of subclinical hypercortisolism in these patients are still under investigation.Objective: To investigate the prevalence of the metabolic syndrome (MS) in pat...

Rathke cleft cysts (RCCs) are non-neoplastic sellar lesions derived from remnants of Rathke’s pouch, and mostly asymptomatic. Symptomatic RCCs occur usually in middle-age, are >1 cm, and cause pituitary hypofunction, diabetes insipidus, hyperprolactinemia or visual impairment. In children, RCCs are rare and usually asymptomatic. However, symptomatic cases may present with growth retardation and diabetes insipidus. We report two children with symptomatic RCC manifestin...