Endocrine Abstracts

We previously reported that calycosin, a natural phytoestrogen structurally similar to estrogen, successfully triggered apoptosis of ER-positive breast cancer cell line, MCF-7. To better understand the antitumor activities of calycosin against breast cancer, besides MCF-7 cells, another ER-positive cell line T-47D was analyzed here, with ER-negative cell lines (MDA-231 and MDA-435) as control. Notably, calycosin led to inhibited cell viability and apoptosis only in ER-positive...

Objective: Propensity score matching (PSM) was used to study whether male patients with differentiated thyroid cancer (DTC) were the risk factors for prognosis after 131I treatment.Methods: 1677 patients with DTC who underwent total thyroidectomy and received 131I treatment were divided into male group (n= 546) and female group (n= 1131). The PSM method was adopted to process all the data to reduce the influence of...

Objectives: Along with better recognition of the role of primary aldosteronism (PA) in increasing cardiovascular risk and the potential of targeted therapy for PA, the long-term mortality according to different treatments are poorly understood.Methods: We investigated PA patients using the validated algorithms between 1999 and 2011. Their data were extracted from the whole claims of the Taiwan National Health Insurance. We used Cox regression with time-v...

Individuals with chronic hypoparathyroidism sometimes receive suboptimal care with high frequency of unplanned hospitalisation and iatrogenic harm. In 2015 the European Society for Endocrinology published evidence base consensus guidelines on the management of chronic hypoparathyroidism. Using these consensus recommendations as audit standards we worked with the Society for Endocrinology and Parathyroid UK to conduct a national audit of management of chronic hypoparathyroidism...

Background: The study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ ophthalmopathy (GO; GD+GO) that can represent the clinical disease characteristics.Methods: A eukaryotic expression plasmid of insulin-like growth factor 1 receptor (IGF-1R) α subunit (pcDNA3.1/IGF-1Rα) and a thyrotropin receptor (TSHR) A subunit plasmid (pcDNA3.1/TSHR-289) were injected in female BALB/c mice to induce a GD+GO model. Grouping w...

ObjectiveIn BALB/c mice with GD model, the TSHR and ICAM-1 were targeted for treatment, and new approaches to GD targeted therapy were explored.MethodsThe siRNA targeting TSHR and the ICAM-1 mAb specifically binding ICAM-1 were designed and synthesized. Thirty GD model mice were randomly divided into siRNA treatment group, ICAM-1 mAb treatment group, and untreated GD group, with 10 mice in each group, and 10 ...

Introduction: As a tumor-suppressor gene, armadillo repeat-containing 5 (ARMC5) gene regulates steroidogenesis and cell apoptosis in manner of second-hit model. Mutations of ARMC5 gene will disturb its normal function, leading to reduced cortisol synthesis and cell apoptosis, which is acknowledged as a frequent cause of primary bilateral macronodular adrenal hyperplasia (PBMAH). Not until another somatic ARMC5 mutation occur in germline mutation carriers, will they manifest as...

Objective: The purpose of this study was to describe the outcome after initiation of exenatide therapy and to determine whether the impact of adverse drug reactions on compliance was affected by gender.Methods: A retrospective study was performed of 18 diabetic patients (eight males) that were prescribed exenatide between June 2013 and September 2014. Each included patient received exenatide for ≥1 month. Age, disease course, race, BMI, medical his...

Objective: To investigate the impact of lifestyle intervention on elevated thyroid peroxidase (TPO) antibody levels in outpatients with normal thyroid function.Methods: A retrospective cohort study was performed to observe and evaluate euthyroid patients with excessive TPO antibodies that presented to the authors’ hospital between March 2013 and October 2014 for routine medical examinations. The subjects were randomly divided into the lifestyle inte...

Background: Impaired Insulin-like growth factor-1 (IGF-1) function is associated with obesity and hypertension, but the correlation of circulating IGF-1 with these conditions is weak. As a metabolite of IGF-1, the ratio of cGP/IGF-1 regulates IGF-1 bioavailability and may be a more accurate biomarker of IGF-1 function in obesity and hypertension.Methods: Using ELISA and HPLCms methodologies, we analysed plasma concentration of IGF-1, cGP and IGFBP-3 in 4...