Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep293 | Clinical case reports - Pituitary/Adrenal | ECE2016

Ectopic prolactin-secreting adenoma at the pituitary stalk

Schilbach Katharina , Schopohl Jochen

Almost all cases of prolactinomas are benign intrasellar micro- or macroadenomas. Very rarely benign prolactinomas are located outside the sella and in most of these cases the tumors are located in the sphenoidal sinus.We here report a 35 year old woman who presented to the clinic with secondary amenorrhoea and galactorrhoea. Initial laboratory testing revealed mild hyperprolactinemia between 1100 and 1600 μU/ml and hypogonadotropic hypogonadism wit...

ea0020p557 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Impact of long-term growth hormone (GH) substitution on lipid metabolism and bone mineralisation (BMD) in pituitary insufficient patients with growth hormone deficiency (GHD)

Roemmler Josefine , Kuenkler Maren , Schopohl Jochen

Introduction: Growth hormone (GH) is a lipolytic hormone with pleitropic metabolic functions. The effects of long-term GH substitution in pituitary insufficient patients with growth hormone deficiency (GHD) on lipid metabolism and bone mineralisation (BMD) have yet to be ascertained.Methods: We measured fasting total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides, glucose and insulin concentrations in 52 GHD on ...

ea0063p252 | Pituitary and Neuroendocrinology 1 | ECE2019

A case of ‘micromegaly’: need for revision of oral glucose tolerance test (OGTT) cut-offs with modern growth hormone assays in acromegaly

Schilbach Katharina , Stormann Sylvere , Bidlingmaier Martin , Schopohl Jochen

The OGTT is the gold standard for confirmation or exclusion of acromegaly in treatment-naïve patients as well as after surgery. According to former guidelines, acromegaly is ruled out if the growth hormone (GH) nadir lies below 1.0 μg/l and 0.4 μg/l pre- and postoperatively, respectively. We present the case of a 40-year-old man who presented to the outpatient clinic in 2014 for endocrinological evaluation after an elevated IGF-I concentration had occasionally b...

ea0063p1067 | Pituitary and Neuroendocrinology 3 | ECE2019

A closer look at pituitary deficiency in Ipilimumab-induced hypophysitis

Stormann Sylvere Schilbar Katharina , Kuppers Anna , Schopohl Jochen , Stormann Sylvere

Introduction: Ipilimumab is a monoclonal antibody directed against CTLA-4 used primarily in treatment of malignant melanoma. Immunological side effects are common, amongst others it may lead to hypophysitis. We studied clinical characteristics of IpiH and compared it to cases of primary hypophysitis (PH).Methods: We conducted a retrospective single centre study in 75 hypophysitis patients (60 primary, 15 Ipilimumab-induced in patients with melanoma). Gro...

ea0037ep815 | Pituitary: clinical | ECE2015

Renal function in acromegaly

Pichl Christine , Stormann Sylvere , Pichler Matthias , Schopohl Jochen

Introduction: Acromegaly is a rare disease resulting from GH excess mostly due to pituitary adenomas. It is associated with changes of most organ systems and multiple comorbidities. The impact of GH and IGF-I excess on renal function in acromegaly is unclear.Methods: We investigated 66 acromegalic patients from our outpatient clinic (32 female, 34 male, mean age 61.5±12.9 years, women 10 years older than men). The renal function was assessed by bloo...

ea0022p547 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Ghrelin and leptin levels in acromegalic patients treated with pegvisomant

Roemmler Josefine , Otto Baerbel , Ayman Arafat , Martin Bidlingmaier , Jochen Schopohl

Introduction: GH rises dose dependently during treatment with the GH receptor antagonist pegvisomant. Ghrelin stimulates GH secretion. In de novo acromegalic patients with high GH levels, ghrelin levels are lowered and fat mass is reduced. Leptin levels are positively correlated to fat mass. We performed this cross-sectional study to evaluate whether elevated endogenous GH in acromegalic patients on pegvisomant treatment (peg) reduces ghrelin and leptin levels.<p class="ab...

ea0016p368 | Growth factors | ECE2008

Leptin and ghrelin serum levels during an oral glucose tolerance test in patients with growth hormone deficiency with and without growth hormone substitution

Roemmler Josefine , Kuenkler Maren , Otto Baerbel , Bidlingmaier Martin , Schopohl Jochen

In GH deficiency (GHD), fat mass is elevated compared to normal subjects. Leptin is positively related to fat mass, BMI and food intake, while ghrelin correlates negatively. During an oral glucose tolerance test (OGTT), leptin increases in obese subjects and generally does not change in normal weight subjects. Ghrelin decreases during OGTT. We performed a cross-sectional study in order to investigate the influence of GH-substitution on leptin and ghrelin in GHD.<p class="a...

ea0056p707 | Clinical case reports - Pituitary/Adrenal | ECE2018

Atypical pituitary adenoma: a case of histological mimicry

Schilbach Katharina , Saeger Wolfgang , Stormann Sylvere , Schopohl Jochen

We present the case of a 67-year-old man who presented to the outpatient clinic for endocrinological evaluation after partial resection of an atypical pituitary adenoma (APA). Pathohistological assessment of two independent and experienced neuropathologists resulted in a diagnosis of APA with unusually high proliferation indices (Ki67 10–20%/p53 30%) and immunoreactivity for LH, FSH and the alpha-subunit. Clinical examination as well as laboratory testing revealed no sign...

ea0081ep692 | Pituitary and Neuroendocrinology | ECE2022

Soluble alpha klotho in blood is a new and highly stable biomarker

Ribeiro de Oliveira Longo Schweizer Junia , Haenelt Michael , Schilbach Katharina , Stormann Sylvere , Schopohl Jochen , Bidlingmaier Martin

Background: Soluble alpha klotho (sαKL) is a circulating protein that has been linked to the growth hormone (GH) axis. We previously showed its association to disease activity in patients with acromegaly, with considerable robustness towards biological confounders. However, there is scarce data in literature regarding the analytical performance of the assay, and pre-analytical stability of sαKL in blood samples. Objective: We aimed to evaluate ...

ea0081ep715 | Pituitary and Neuroendocrinology | ECE2022

Growth hormone leading to faster recovery in pure motor Guillain-Barre syndrome: report of the first off-label use in one patient

Amereller Felix , Jochen Schopohl , Sylvere Stormann , Martin Bidlingmaier , Peter Rieckmann , Philipp Gulde

Background: Although the prognosis inGuillain-Barré syndrome (GBS) is generally good, the protracted and sometimes incomplete recovery is a heavy burden for patients. Animal studies suggest that treatment with growth hormone (GH) could stimulate myelin repair and thus accelerate functional recovery in acute polyneuropathy. We report on the first use of GH in GBS.Objective: To monitor safety and tolerability as well as to evaluate the effect of off-l...