Searchable abstracts of presentations at key conferences in endocrinology

ea0041s4.1 | How to diagnose endocrine disease in obese patients? (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>) | ECE2016

HPA axis abnormalities and metabolic syndrome

Kassi Eva

MetS is a cluster of interconnected factors that directly increase the risk of cardiovascular atherosclerotic diseases, and diabetes mellitus type 2. Visceral obesity/insulin resistance have gained increasing attention as the core manifestations of the syndrome. HPA axis is one of the main stress response pathways. Apart from having a circadian activity also mediates the adaptive response to stressors. A growing body of evidence point towards a strong relationship between pert...

ea0081p641 | Endocrine-Related Cancer | ECE2022

Management and long term follow up of hyperparathyroidism in multiple endocrine neoplasia type 1: single center experience

Yavropoulou Maria , Vlachou Sofia , Tsoli Marina , Fostira Florentia , Kaltsas Gregory , Kassi Eva

Background and objective: Multiple Endocrine Neoplasia type 1 (MEN 1) is an autosomal dominant disease characterized by a broad clinical spectrum. Previous multi-center studies, that analyzed large groups of patients with MEN 1 have been reported before but long term follow up data of these patients focusing exclusively on primary hyperparathyroidism (PHPT) are scarce.Patients and Methods: In this retrospective cohort study we include all patients with P...

ea0063gp155 | Cushing's | ECE2019

Endocrine immune-related adverse events following immune checkpoint inhibitors in patients with advanced melanoma: single-center retrospective analysis

Kassi Eva , Angelousi Anna , Asonitis Nikos , Petychaki Foteini , Diamantopoulos Panayiotis , Anastasopoulou Amalia , Benopoulou Olga , Gogas Helen

Introduction: Immune-check point inhibitors (ICPis) has been shown to significantly improve survival in patients with advanced melanoma. Immune-related endocrinopathies (irEs) and in particular hypophysitis and thyroid dysfunction have been well described with an incidence varying from 9–17% and 3.8–13.2% respectively.Methods: This is a retrospective analysis of irEs in 325 (190 men) patients with melanoma receiving ICPis (PD-1/PDL-1 or CTLA-4 ...

ea0063p20 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

A case series of metastatic pheochromocytomas and paragangliomas: patients characteristics, therapeutic approach and follow-up

Angelousi Anna , Kassi Eva , Peppa Melpomeni , Chrysoulidou Alexandra , Zografos George , Aggeli Chrysanthi , Kaltsas Grigorios

Background: Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine neoplasms with a <1:106 incidence, defined by the presence of metastatic disease besides recurrent or locally invasive disease.Aim: Retrospective analysis of clinical, biochemical/hormonal, imaging, genetic and histopathological features of patients with malignant PCs/PGLs diagnosed over 15 years.Results: Thirteen patient...

ea0041gp170 | Receptors &amp; Signalling | ECE2016

Altered exression of circadian clock genes in polyglandular autoimmune syndrome type III

Angelousi Anna , Nasiri-Ansari Narjes , Spilioti Eliana , Kalotychou Vasiliki , Chrousos George , Kaltsas Gregory , Kassi Eva

Introduction: CLOCK system is a highly conserved, ubiquitous molecular ‘clock’ which creates internal circadian rhythmicity under the influence of light/dark information. CLOCK system is regulated by the coordinated activation/inactivation of several transcription factors, including the CLOCK, the BMAL1 and other essential regulators, such as the Pers, Crys and RORs. The present study aimed to evaluate the circadian rhythm of clock-related genes expressed in patients...

ea0041ep772 | Nuclear receptors and Signal transduction | ECE2016

Effects of vitamin D on endothelial-derived factors implicated in the atheromatic plaque vulnerability

Rizou Aspasia , Nasiri-Ansari Narjes , Spilioti Eliana , Kalotychou Vasiliki , Moutsatsou Paraskevi , Athanasios Papavassiliou , Kassi Eva

Introduction: Although the protective effects of 1,25(OH)2D3 on the early stages of atheromatosis process have been investigated, data on its influence on factors implicated in plaque vulnerability are limited. During these stages metalloproteinases MMP-2, MMP-9, their inhibitors TIMP-1,TIMP-2, the RANKL-RANK-OPG system and MCP-1 play a critical role. We aimed to investigate the effect of vitamin D on the expression of the above factors on endothelial cel...

ea0037oc5.2 | Steroids, developmental and paediatric endocrinology | ECE2015

Vitamin D decreases in vitro glucocorticoid sensitivity via down regulation of glucocorticoid receptor expression

Ansari Narjes Nasiri , Spilioti Eliana , Kalotychou Vasiliki , Dalagiorgou Geena , Moutsatsou Paraskevi , Papavassiliou Athanasios , Kassi Eva

Introduction: Glucocorticoids (GCs) are used in the treatment of chronic inflammatory or autoimmune diseases. However, patients are often resistant to the GC effects. Response to GCs is triggered through glucocorticoid receptor (GR). An important regulator of GR activity is the FKBP5. FKBP5 binds to co-chaperones promoting a conformation with lower cortisol affinity. The number of GRs is another determinant of GC sensitivity; GR expression is regulated by the nuclear ...

ea0037gp.09.06 | Nuclear receptors and signalling | ECE2015

Effects of estrogens on endothelial-derived factors implicated in the atheromatic plaque vulnerability-clarification of the molecular mechanisms

Ansari Narjes Nasiri , Spilioti Eliana , Kalotychou Vasiliki , Dalman-Wright Karin , Moutsatsou Paraskevi , Papavassiliou Athanasios , Kassi Eva

Introduction: In the presence of atherogenic plaque, estrogens may be potentially harmful. Among the key vessel wall components in the later stages of atherogenic process are endothelial cells (ECs). During the stages of plaque instability/rupture, metalloproteinases (MMP2 and MMP9), their inhibitors (TIMP2 and TIMP1), RANK, RANKL, OPG, MCP1, lysyl oxidase (LOX), PDGF, and ADAMTS4 play critical role. We aimed to investigate i) the effect of oestrogens on the expression of the ...

ea0056p673 | Nuclear receptors and Signal transduction | ECE2018

Vitamin D abolishes the dexamethasone-induced apoptosis in acute myeloid leukemia cells via regulation of Notch signaling

Karapanagioti Angeliki G , Nasiri-Ansari Narjes , Angelousi Anna , Kalotychou Vasiliki , Papavasilliou Athanasios G , Kassi Eva

Introduction: Glucocorticoids are used for treatment of various hematological malignancies such as Acute Myeloid Leukemia (AML). Glucocorticoids are known to induce apoptosis by regulating the expression of key anti- or pro-apoptotic genes. Vitamin D induces apoptosis and cell cycle arrest in various types of cancer cells. Despite recent advances in treatment of AML, the poor response rate to therapy remains a big challenge.Therefore, discovering new factors that can affect th...

ea0056p1143 | Thyroid cancer | ECE2018

The significance of postoperative calcitonin (CT) levels in the evaluation of disease course in medullary thyroid cancer (MTC) patients

Saltiki Katerina , Simeakis George , Vogiatzi Evangelia , Kassi Eva , Zapanti Evangelia , Alevizaki Maria

Aim: Postoperative calcitonin (postCT) is a prognostic factor for disease progression in MTC patients. We evaluated the disease course in patients with persistently elevated post-CT.Methods: Of all MTC patients (n=273) followed-up in our Unit (for 1–37, median 7 years), 140 (39.3% men, 67.1% sporadicMTCs) had persistently elevated postCT (≥2.0 pg/ml). Clinical and biochemical data were recorded. Patients were classified in four groups...