Searchable abstracts of presentations at key conferences in endocrinology

ea0073ep1 | Adrenal and Cardiovascular Endocrinology | ECE2021

A case report of metastatic adrenocortical carcinoma

Dayssem Khelifi , Iadh Ksira , Hedi Krifa

IntroductionAdrenocortical carcinoma is a rare neoplasm with local development, rarely metastatic in the spine. We report a case of metastatic dorsal spinal cord compression due to adrenocortical carcinoma.ObservationA 38-year-old lady with no notable medical history, complained of generalised weakness, severe abdominal pain and spasms. Abdominal computed tomography showed a large right adrenal renal mass mea...

ea0081ep831 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly in the elderly patients

Khelifi Dayssem , Khessairi Nadia , Terzi Ameni , Grira Wafa , Chihaoui Melika

Introduction: Pituitary adenomas in people over 65 represent less than 10% of all pituitary adenomas, 80% of which are non-functional. Somatotropic adenomas remain very rare. The interest of our study is to describe the clinical, paraclinical and therapeutic profile of cases of senile acromegaly.Patients and methods: This is a retrospective study of four senile acromegaly patients followed in our endocrinologyÂ’s department.Res...

ea0073aep352 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Bullosis diabeticorum

Khelifi Dayssem , Bacha Takwa , Jones Meriem , Litaiem Noureddine , Zeglaoui Faten

IntroductionSkin damage is common in diabetes. They can be classified into three groups: dermatoses associated with diabetes, acute and chronic skin complications of diabetes and dermatoses associated with antidiabetic treatments. Bullosis in diabetics, also called Bullosis diabeticorum, is one of the cutaneous complications of diabetes. It is a rare bullous dermatosis particular by its exclusive occurrence in diabetics.Observation...

ea0073aep374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Wolfram syndrome: A diagnostic challenge

Khelifi Dayssem , Debbabi Wided , Kharrat Issam , Samet Slim

IntroductionWolfram syndrome (also known as DIDMOAD syndrome) is a rare, genetic, endocrine disorder characterized by the early onset of diabetes mellitus and optic atrophy. It is frequently associated with diabetes insipidus, deafness and neurological signs.ObservationA 26-year-old woman was burn out of a consanguineous marriage. Diabetes mellitus was revealed at the age of 6 by ketoacidosis, treated from th...

ea0073ep36 | Calcium and Bone | ECE2021

Cerebral calcifications revealing familial pseudohypoparathyroidism

Khelifi Dayssem , Debbabi Wided , Kharrat Issam , Samet Slim

IntroductionPseudohypoparathyroidism (PHP) is the first example of hormonal resistance observed in human pathology characterized by a great variability of clinical and genetic expression. We present a case of PHP in a Tunisian family.ObservationThe index case is a 31-year-old man. He was burn out of a consanguineous marriage (distant consanguinity) followed since the age of 15 for convulsive seizures. Three m...

ea0081p367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metformine: anti-fibrotic molecule?

Khelifi Dayssem , Ben Nacef Ibtissem , Bouzid Kahena , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Background and aims: Diabetes causes tissue fibrosis by still poorly understood mechanisms which involve glycation products. Galectin-3 (Gal-3) is an emerging key player in metabolic disorders and a powerful factor in the development and progression of the fibrotic process in target organs in diabetic patients. The plasma level of Gal-3 increases during diabetic cardiomyopathy and diabetic nephropathy. We have studied the correlation between serum Gal-3 level and anti-diabetic...

ea0081p374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Threshold value of galectine-3 in a Tunisian diabetic population

Khelifi Dayssem , Nacef Ibtissem Ben , Bouzid Kahena , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Background and aims: Plasma Galectin-3 (Gal-3), mediator of fibrogenesis and inflammation, has been implicated in many diseases. Particularly in diabetics, this lectin directly mediates transdifferentiation in collagen-producing cells thus leading to fibrosis of target organs and accelerating the development of complications. The objective of our study was to determine a cut-off value for Gal-3 in our population.Methods: We conducted a cross-sectional, a...

ea0073ep146 | Pituitary and Neuroendocrinology | ECE2021

A case of primary amenorrhea revealing a macroprolactinoma

Khelifi Dayssem , Rojbi Imen , Ben Nacef Ibtissem , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

IntroductionPrimary amenorrhea should be considered in any patient who has not experienced periodic menstruation by 16 years regardless of the presence of normal growth and development of secondary sexual characteristics.Observation17-year-old patient, who exhibited normal secondary sexual characteristics, normal auxiliary and pubic hairs, normal breast development since the age of 12 with the non-appearance ...