Searchable abstracts of presentations at key conferences in endocrinology

ea0056p1141 | Thyroid cancer | ECE2018

Medullary thyroid carcinoma: a case report on the efficacy and safety of combined treatment with Vandetanib and Lanreotide Autogel

Kalantzi Athanasia , Papanastasiou Labrini , Charalabidou Liana , Lyberopoulos Konstantinos , Kounadi Theodora

Introduction: Treatment options for progressive metastatic unresectable medullary thyroid carcinoma (MTC) include tyrosine kinase inhibitors (TKIs) or somatostatin analogues (SSA), although the efficacy of the latter is debatable. In such cases, combined treatment of TKIs and SSAs has not previously been reported.Aim: To present a metastatic MTC case successfully treated with a combination of Vandetanib and Lanreotide Autogel.Case ...

ea0063p416 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

High prevalence of autonomous aldosterone secretion in patients with type 2 Diabetes Mellitus and arterial hypertension. The effect of SGLT2 inhibitors on renin-angiotensin-aldosterone system

Tyfoxylou Ernestini , Papanastasiou Labrini , Piaditis George , Voulgaris Nikolaos , Chrousos George , Kounadi Theodora

Introduction: The causes of arterial hypertension in diabetic and non-diabetic hypertensive patients are still not clear. However, in recent studies in non-diabetic hypertensive patients (NDHP) we observed dysregulation of aldosterone (ALD) secretion either in the form of autonomous secretion or as hyperesponse to stress. To the best of our knowledge, a similar study in hypertensive patients with type 2 Diabetes Mellitus (DHP) has not been conducted yet....

ea0063p620 | Diabetes, Obesity and Metabolism 2 | ECE2019

Next generation sequencing reveals ABCC8 (MODY 12) variants in two families with diabetes mellitus (DM)

Markou Athina , Sertedaki Amalia , Tatsi Elizabeth , Piaditis George , Kounadi Theodora , Kanaka-Gantenbein Christina

Introduction: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by autosomal dominant inheritance, early onset diabetes, defect in the β-cell insulin secretion, positive family history, absence of diabetic ketoacidosis, auto-antibodies and insulin resistance. To date, 14 different MODY subtypes have been reported each one with distinct genetic etiology, however MODY patie...

ea0035p475 | Diabetes therapy | ECE2014

Improvement of HbA1c is blunted following discontinuation of an on-line telemonitoring system, in patients with inefficiently controlled insulin-treated diabetes mellitus

Fountoulakis Stelios , Papanastasiou Labrini , Malliopoulos Dimosthenis , Marakaki Chrisanthi , Markou Athina , Kounadi Theodora , Piaditis George

Aim: Primary goal was to determine whether the improvement of HbA1c, observed in inefficiently insulin-treated diabetes mellitus (DM) patients on a telemonitoring system, had a lasting effect following its discontinuation.Methods: Forty-seven DM patients (mean age 56.15±15.86 years, mean BMI 29.44±6.69 kg/m2, mean HbA1c 9.9±2.62%) and 25 insulin-treated matched controls (mean age 56.16±20.11 years, mean BMI 27.6±5.18 k...

ea0070aep67 | Adrenal and Cardiovascular Endocrinology | ECE2020

Hyperparathyroidism in patients with overt and mild primary aldosteronism: Epidemiological data from a tertiary centre

Gravvanis Christos , Papanastasiou Labrini , Glikofridi Spyridoula , Voulgaris Nikolaos , Tyfoxylou Ernestini , Kounadi Theodora

Introduction: Primary aldosteronism (PA) is the most common cause of endocrine hypertension. In recent studies, increased prevalence of hyperparathyroidism (HP) has been observed in PA patients. However, the prevalence of HP in overt or milder forms of PA has not been evaluated yet.Objectives: To estimate the prevalence of HP in patients with PA (overt and milder forms) and investigate the effect of treatment (eplerenone or surgery) on PTH secretion....

ea0070aep360 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Arare case of caucasian patient with insulin autoimmune syndrome induced by a-lipoic acid

Glikofridi Spyridoula , Papanastasiou Labrini , Markou Athina , Andrianesis Vasileios , Gravvanis Christos , Kounadi Theodora

Introduction: Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies (IA) in the absence of exogenous insulin administration. The occurrence of IAS may be influenced by a genetic predisposition determined by HLA class II. IAS is frequently reported in Japanese and Koreans due to their genetic predisposition (HLA-DRB1*0406) rather than in the Caucasians. Some drugs containing sulfhydryl compounds are known to initiate the...

ea0070ep25 | Adrenal and Cardiovascular Endocrinology | ECE2020

Plasma metanephrines and normetanephrines: Alternative indices of avs in a patient with primary aldosteronism and endogenous hypercortisolemia

Nikitas Skarakis Spyridon , Papadimitriou Irene , Papanastasiou Labrini , Diamantis Evangelos , Gravanis Miltiadis , Karydas Georgios , Kounadi Theodora

Background: Adrenal venous sampling (AVS) is the gold standard method that evaluates the source of aldosterone overproduction in primary aldosteronism. During AVS aldosterone and cortisol are simultaneously measured in order to assess successful adrenal cannulation and lateralization of aldosterone overproduction. However, in patients with both adrenal cortisol and aldosterone overproduction, plasma metaneprhines and normetanephrines can be measured to overcome selectivity and...

ea0073aep323 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Identification of a novel mutation of the abcc8 gene in a greek subject with mody12

Kanti Georgia , Papanastasiou Labrini , Sertedaki Amalia , Glikofridi Spyridoula , Gantenbein Christina Kanaka , Kounadi Theodora

Introduction’Maturity-onset diabetes of the young’ (MODY) constitutes a group of clinically and genetically heterogeneous monogenic forms of diabetes, characterized by beta-cell dysfunction. It describes an autosomal dominantly inherited disorder, caused by mutations in different genes, characterized by noninsulin-dependent diabetes commonly diagnosed at a young age. Fourteen MODY subtypes have been reported, often misdiagnosed as type 1 or 2 d...

ea0081p522 | Adrenal and Cardiovascular Endocrinology | ECE2022

Gastric monomorphic epitheliotropic intestinal T-cell lymphoma with bilateral adrenal metastases

Kaliakatsou Eirini , Markou Athina , Papanastasiou Labrini , Giagourta Irini , Kalantzi Athanasia , Dimitriadi Anastasia , Lenos Michael , Kounadi Theodora , Fountas Athanasios

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy-associated T-cell lymphoma, is a rare and aggressive subtype of lymphoma of the gastrointestinal track typically noted in Asian or Hispanic populations. Adrenal involvement as part of MEITL is extremely rare. Herein we present a patient of Greek origin with MEITL and bilateral adrenal metastases.Case Presentation: A 74-year-old man presente...

ea0063p91 | Calcium and Bone 1 | ECE2019

Effectiveness of intramuscular Ergocalciferol treatment in a patient with o steomalaciadueto severe vitamin D deficiencyafterbariatric surgery

Papanastasiou Labrini , Gravvanis Christos , Tournis Symeon , Markou Athina , Kalantzi Athanasia , Zoulias Manolis , Georgakopoulou Georgia , Pagoni Stamatina , Kounadi Theodora

Bariatric surgery is a common treatment for morbidly obese patients requiring weight loss and/or metabolic control. Vitamin D (VitD) deficiency and bone loss may occur post-operatively and supplementation with high oral doses of Vitamin D is required. Alternatively, intramuscular depot ergocalciferol (vitamin D2) which slowly releases VitD and overcomes the gastrointestinal tract, could be administrated in such patients.Aim: To present a case of severe V...