Endocrine Abstracts

Coronavirus disease 19 (COVID-19) started to quickly spread worldwide in the end of 2019 and was declared by the WHO a pandemic on March 11, 2020. Prevailing signs and symptoms of COVID-19 comprise many organ systems and are very complex and variable and also even unpredictable and lead to tremendous increase in morbidity and mortality. Recently, there has been increasing evidence that COVID-19 affects in a complex way also the endocrine system. Renin-angiotensin-aldosterone s...

Background: The consequences of overt hypothyroidism on the central nervous system are well known. Interestingly, there is less proof in regards to the impacts of subclinical hypothyroidism (SCH) on the cognitive functions among elderly subjects. Studies from various countries including India have shown a variable association between SCH and cognitive dysfunction. This study planned to survey the event of cognitive impairment among the older Indian subjects who were introducin...

Introduction: Increase in global childhood obesity is considered to be one of the detrimental problems all across the world. It is well known that about every 1 in every 300-500 infants suffers from Type-1 Diabetes Mellitus. Obesity has been directly associated with elevation of blood sugar and HbA1c.Objective: This study investigates the prevalence of obesity in Type-1 DM and the distribution of sex, age and its correlation with HbA1.<p class="abste...

Introduction: Acute and chronic alcohol intake and alcohol withdrawal induce dysfunction of neuroendocrine and other regulatory systems. The expression ‘neuroendocrine dysfunction’ alludes to an assortment of conditions brought about by imbalances in the body’s chemical creation straightforwardly connected with the pituitary, nerve center, and their tomahawks following TBI.Aims: This study aimed to assess a possible hypothalamo-pituitary-a...

Hypercalcaemia is a commonly encountered problem. Though primary hyperparathyroidism and malignancy account for greater than 90% of cases other rare causes need to be considered. We present an unusual but significant cause of hypercalcaemia.Of 87-year-old gentleman presented with acute abdominal pain and a severe hypercalcaemia with corrected serum calcium of 4.36 mmol/l (2.1–2.6). Significant dehydration was associated with acute renal failure (Tab...

Index case and aimsA 26 year old woman was referred to our endocrine clinic with infertility and raised testosterone levels. Clinical examination was completely normal, with no hirsuitism or virilizing features. She had normal gonadotropin and SHBG levels, but had elevated testosterone (6.6 nmol/l (0.5–2.8) and dehydroepiandrosterone sulphate (DHEA-S) levels (13.5 umol/l (1.4–11.1)). To exclude the possibility of interference in our direct assa...

Introduction: Duplications of the SOX3 gene at Xq27.1 are known to be associated with a spectrum of forebrain midline defects, isolated or multiple pituitary hormone deficiencies, spina bifida and sometimes learning difficulties. We report three cases of SOX3 duplication with hypopituitarism and differing presentations.Case reports: 1) A male infant presented in neonatal period with poor feeding, prolonged jaundice, central hypothyroidism and inadequate ...

Background: Non-alcoholic fatty liver disease and chronic hepatitis C (CHC) are systemic diseases with a broad spectrum of coexisting disorders, but their common features are insulin resistance and higher frequency of concomitant type 2 diabetes mellitus (DM). According to recent studies, a higher frequency of CHC in patients with DM is not associated with this cohort exposure to multiple medical interventions, but with CHC being a possible risk factor for developing DM. CHC m...

The most effective conventional treatment for differentiated thyroid cancer (DTC) still remains total thyroidectomy with subsequent adjuvant therapy with radioiodine ablation (RAI). In case of unsuccessful RAI treatment, an alternative method is the tyrosine kinase inhibitor therapy. However, its usage is related to many side effects and is not well tolerated by patients. Despite the great progress in the clinical management of patients with DTC, the lack of alternative therap...

ObjectiveIt has been shown that treatment with radioactive iodine (RAI) of women with differentiated thyroid cancer (DTC) is connected with decreased serum concentration of anti-Müllerian hormone (AMH). To date, others markers connected with ovarian reserve have not been investigated yet. Therefore, the aim of the present study was to evaluate the effect of RAI on serum concentration of inhibin B, follicle stimulating hormone (FSH), AMH and antral f...