Searchable abstracts of presentations at key conferences in endocrinology

ea0081s17.3 | Infections and endocrinology | ECE2022

Endocrine and metabolic aspects of COVID-19

Kršek Michal

Coronavirus disease 19 (COVID-19) started to quickly spread worldwide in the end of 2019 and was declared by the WHO a pandemic on March 11, 2020. Prevailing signs and symptoms of COVID-19 comprise many organ systems and are very complex and variable and also even unpredictable and lead to tremendous increase in morbidity and mortality. Recently, there has been increasing evidence that COVID-19 affects in a complex way also the endocrine system. Renin-angiotensin-aldosterone s...

ea0081p484 | Thyroid | ECE2022

Assessing cognitive functions among elderly patients with subclinical hypothyroidism

Shankar Anand , Guha Shaibal , Kr Das Amit , Kumar Subhash

Background: The consequences of overt hypothyroidism on the central nervous system are well known. Interestingly, there is less proof in regards to the impacts of subclinical hypothyroidism (SCH) on the cognitive functions among elderly subjects. Studies from various countries including India have shown a variable association between SCH and cognitive dysfunction. This study planned to survey the event of cognitive impairment among the older Indian subjects who were introducin...

ea0081ep485 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between Type-1 diabetes and obesity

Kumar Subhash , Shankar Anand , Guha Shaibal , Das Amit Kr

Introduction: Increase in global childhood obesity is considered to be one of the detrimental problems all across the world. It is well known that about every 1 in every 300-500 infants suffers from Type-1 Diabetes Mellitus. Obesity has been directly associated with elevation of blood sugar and HbA1c.Objective: This study investigates the prevalence of obesity in Type-1 DM and the distribution of sex, age and its correlation with HbA1.<p class="abste...

ea0081ep840 | Pituitary and Neuroendocrinology | ECE2022

Evaluation of neuroendocrine dysfunction in the diagnosis of depressive and non-depressive alcohol-dependent persons

Guha Shaibal , Shankar Anand , Das Amit Kr , Kumar Subhash

Introduction: Acute and chronic alcohol intake and alcohol withdrawal induce dysfunction of neuroendocrine and other regulatory systems. The expression ‘neuroendocrine dysfunction’ alludes to an assortment of conditions brought about by imbalances in the body’s chemical creation straightforwardly connected with the pituitary, nerve center, and their tomahawks following TBI.Aims: This study aimed to assess a possible hypothalamo-pituitary-a...

ea0019p43 | Clinical practice/governance and case reports | SFEBES2009

Unusual presentation of non – PTH dependant hypercalcaemia

Arutchelvam V , Foulkes A , Napier C , Madathil A , Razvi S , Narayanan KR

Hypercalcaemia is a commonly encountered problem. Though primary hyperparathyroidism and malignancy account for greater than 90% of cases other rare causes need to be considered. We present an unusual but significant cause of hypercalcaemia.Of 87-year-old gentleman presented with acute abdominal pain and a severe hypercalcaemia with corrected serum calcium of 4.36 mmol/l (2.1–2.6). Significant dehydration was associated with acute renal failure (Tab...

ea0012p107 | Reproduction | SFE2006

Prevalence of assay interference in women with high serum testosterone levels

Ravikumar B , Handley G , Weaver JU , Oxynos C , Narayanan KR

Index case and aimsA 26 year old woman was referred to our endocrine clinic with infertility and raised testosterone levels. Clinical examination was completely normal, with no hirsuitism or virilizing features. She had normal gonadotropin and SHBG levels, but had elevated testosterone (6.6 nmol/l (0.5–2.8) and dehydroepiandrosterone sulphate (DHEA-S) levels (13.5 umol/l (1.4–11.1)). To exclude the possibility of interference in our direct assa...

ea0051p043 | Pituitary and growth | BSPED2017

SOX3 gene duplication (OMIM 313430) associated with midline CNS malformations, hypopituitarism and neurodevelopmental abnormalities: 3 unrelated cases

Nambisan Aparna K.R. , Kapoor Ritika , Ajzensztejn Michal , Hulse Tony , Buchanan Charles R.

Introduction: Duplications of the SOX3 gene at Xq27.1 are known to be associated with a spectrum of forebrain midline defects, isolated or multiple pituitary hormone deficiencies, spina bifida and sometimes learning difficulties. We report three cases of SOX3 duplication with hypopituitarism and differing presentations.Case reports: 1) A male infant presented in neonatal period with poor feeding, prolonged jaundice, central hypothyroidism and inadequate ...

ea0063p607 | Diabetes, Obesity and Metabolism 2 | ECE2019

Liver fibrosis and steatosis severity evaluation in patients with chronic hepatitis C and type 2 diabetes mellitus

Irina Morozova , Beliy PA , Axelrod AG , Rodnikova EM , Dudina KR , Safiullina NH , Znoyko OO

Background: Non-alcoholic fatty liver disease and chronic hepatitis C (CHC) are systemic diseases with a broad spectrum of coexisting disorders, but their common features are insulin resistance and higher frequency of concomitant type 2 diabetes mellitus (DM). According to recent studies, a higher frequency of CHC in patients with DM is not associated with this cohort exposure to multiple medical interventions, but with CHC being a possible risk factor for developing DM. CHC m...

ea0073aep390 | Endocrine-Related Cancer | ECE2021

Assessment of different markers of ovarian reserve in women with differentiated thyroid cancer treated with radioactive iodine

Adamska Agnieszka , Tomczuk-Bobik Paulina , Anna Poplawska-Kita , Siewko Katarzyna , Angelika Buczynska , Szumowski Piotr , Łukasz Żukowski , Janusz Myśliwiec , Monika Zbucka-Krętowska , Adam Krętowski

ObjectiveIt has been shown that treatment with radioactive iodine (RAI) of women with differentiated thyroid cancer (DTC) is connected with decreased serum concentration of anti-Müllerian hormone (AMH). To date, others markers connected with ovarian reserve have not been investigated yet. Therefore, the aim of the present study was to evaluate the effect of RAI on serum concentration of inhibin B, follicle stimulating hormone (FSH), AMH and antral f...

ea0086p280 | Thyroid | SFEBES2022

Novel targets determination among patients with angioinvasive differentiated thyroid cancer

Buczyńska Angelika , Sidorkiewicz Iwona , Kościuszko Maria , Adamska Agnieszka , Siewko Katarzyna , Zbucka-Krętowska Monika , Jacek Krętowski Adam , Popławska-Kita Anna

The most effective conventional treatment for differentiated thyroid cancer (DTC) still remains total thyroidectomy with subsequent adjuvant therapy with radioiodine ablation (RAI). In case of unsuccessful RAI treatment, an alternative method is the tyrosine kinase inhibitor therapy. However, its usage is related to many side effects and is not well tolerated by patients. Despite the great progress in the clinical management of patients with DTC, the lack of alternative therap...