Searchable abstracts of presentations at key conferences in endocrinology

ea0063mte5 | (1) | ECE2019

Risk classification of thyroid nodules by ultrasound and indications for FNA

Leenhardt Laurence

Objectives: Thyroid ultrasound (US) is a key examination for the management of thyroid nodules. Thyroid US is easily accessible, noninvasive, cost-effective and is a mandatory step in the workup of thyroid nodules. Thyroid US assessment of the risk of malignancy is crucial in patients with nodules, in order to select those who should have a fine needle aspiration (FNA) biopsy performed. Specific US features suggestive of malignancy have been recognized and described in literat...

ea0026mte3 | (1) | ECE2011

Management difficulties in recurrences and metastases of thyroid cancer

Leenhardt Laurence

Patients with thyroid carcinoma are usually considered as having a good prognosis although the disease may take an aggressive course. Indeed, 5–27% of patients develop locoregional recurrences located in cervical lymph nodes (60–75%), thyroid bed (20%) and trachea or muscle (5%), thus worsening the prognosis. Distant metastases develop in 10% of patients and are located mainly in the bones and the lungs but also in the liver leading to a risk of cancer-related death....

ea0032p1013 | Thyroid (non-cancer) | ECE2013

An open-label, randomized, controlled study of the effectiveness and safety of a high intensity focused ultrasound device compared with observation in patients with non-malignant cold thyroid nodules

Leenhardt Laurence , Rouxel Agnes , Menegaux Fabrice , Esnault Olivier

Aim: To compare nodule volume change at 6 months follow-up in patients treated by ultrasound guided high intensity focused ultrasound (US-HIFU) with patients undergoing observation in a simple monocentric, open label, randomized-control study.Patients and methods: The study was IRB approved and all patients signed an informed consent. 32 patients with 34 benign cold thyroid nodules indicated for surgery were recruited for the study: 21 patients assigned ...

ea0063gp256 | Thyroid Nodules and Cancer 2 | ECE2019

Impact of age at the diagnosis of radioiodine resistance in differentiated thyroid cancer patients

Saie Clotilde , Wassermann Johanna , Mathy Elise , Tezenas Sophie , Chereau Nathalie , Leenhardt Laurence , Buffet Camille

Background: Clinical predictors of survival of radioiodine-refractory differentiated thyroid cancer (RR-DTC) are poorly described. Age has been identified as a major prognostic factor in differentiated thyroid cancer. We asked whether age was a valuable predictor of poor prognosis in RR-DTC.Patients and method: This single centre, retrospective study enrolled all patients diagnosed with a RR-DTC between 1991 and 2017. The primary end point was overall su...

ea0092ps1-01-05 | Cancer | ETA2023

Radioiodine therapy for thyroid cancer and dyfunction of the salivary and lachrymal glands in the start study: results at 6 months follow-up

Baudin Clemence , Bressand Alice , Buffet Camille , Menegaux Fabrice , Soret Marine , Broggio David , Bassinet Celine , Huet Christelle , Leenhardt Laurence , Bernier Marie-Odile , Lussey-Lepoutre Charlotte

Background: Understanding of changes in salivary and lachrymal gland functions after radioiodine therapy (131I-therapy) remains limited; and, to-date no studies have evaluated dose-response relationships between absorbed dose from 131I-therapy and dysfunctions of these glands. This study investigates salivary/lachrymal dysfunctions in differentiated thyroid cancer (DTC) patients six months after 131I-therapy, identifies 131I-therapy related risk ...

ea0092ps3-28-06 | Translational 2 | ETA2023

Next-generation-sequencing on fine needle aspirates in neck recurrence of thyroid cancers

Theodon Helene , Buffet Camille , Guillerm Erell , Wasserman Johanna , Deniziaut Gabrielle , Jaffrelot Loic , Denis Jerome , Chereau Nathalie , Bigorgne Claude , Potonnier Wiame , Coulet Florence , Leenhardt Laurence

Objectives: Tumor molecular genotyping plays a key role in improving the management of advanced thyroid cancers. Molecular tests are classically performed on Formalin-Fixed Paraffin-Embedded (FFPE) carcinoma tissue. However alternative molecular testing strategies are needed when FFPE tumoral tissue is unavailable. The objective of our study was to retrospectively assess the performance of targeted DNA and RNA-based Next Generation Sequencing (NGS) on the fine needle aspirate ...

ea0049gp148 | Male Reproduction and Endocrine Disruptors | ECE2017

Impacts of a single ablative dose of radio iodine therapy for differentiated thyroid carcinoma on testicular function: results from the SAPIRA study

Bourcigaux Nathalie , Rubino Carole , Berthaut Isabelle , Donadille Bruno , Toubert Marie Elisabeth , Leenhardt Laurence , Corone Catherine , Petrot-Keller Isabelle , Brailly-Tabard Sylvie , Beaufaron Julie , Simon Tabassome , Siffroi Jean-Pierre , De Vathaire Florent , Sclumberger Martin , Bouchard Philippe , Christin-Maitre Sophie

Background: Radioactive iodine therapy (RAI) is a classical therapeutic approach in patients with differentiated thyroid carcinoma (DCT). Few data are currently available on RAI’s potential impacts on testicular function.Design: A longitudinal prospective multi-center study (PHRC N°P040419) included male patients before a single radioiodine dose of 3.7 GBq of I 131 (V0), at 3 months (V3) and 13 months (V13) post treatment.<p clas...