Endocrine Abstracts

Objectives: Thyroid ultrasound (US) is a key examination for the management of thyroid nodules. Thyroid US is easily accessible, noninvasive, cost-effective and is a mandatory step in the workup of thyroid nodules. Thyroid US assessment of the risk of malignancy is crucial in patients with nodules, in order to select those who should have a fine needle aspiration (FNA) biopsy performed. Specific US features suggestive of malignancy have been recognized and described in literat...

Patients with thyroid carcinoma are usually considered as having a good prognosis although the disease may take an aggressive course. Indeed, 5–27% of patients develop locoregional recurrences located in cervical lymph nodes (60–75%), thyroid bed (20%) and trachea or muscle (5%), thus worsening the prognosis. Distant metastases develop in 10% of patients and are located mainly in the bones and the lungs but also in the liver leading to a risk of cancer-related death....

Aim: To compare nodule volume change at 6 months follow-up in patients treated by ultrasound guided high intensity focused ultrasound (US-HIFU) with patients undergoing observation in a simple monocentric, open label, randomized-control study.Patients and methods: The study was IRB approved and all patients signed an informed consent. 32 patients with 34 benign cold thyroid nodules indicated for surgery were recruited for the study: 21 patients assigned ...

Background: Clinical predictors of survival of radioiodine-refractory differentiated thyroid cancer (RR-DTC) are poorly described. Age has been identified as a major prognostic factor in differentiated thyroid cancer. We asked whether age was a valuable predictor of poor prognosis in RR-DTC.Patients and method: This single centre, retrospective study enrolled all patients diagnosed with a RR-DTC between 1991 and 2017. The primary end point was overall su...

Background: Understanding of changes in salivary and lachrymal gland functions after radioiodine therapy (131I-therapy) remains limited; and, to-date no studies have evaluated dose-response relationships between absorbed dose from 131I-therapy and dysfunctions of these glands. This study investigates salivary/lachrymal dysfunctions in differentiated thyroid cancer (DTC) patients six months after 131I-therapy, identifies 131I-therapy related risk ...

Objectives: Tumor molecular genotyping plays a key role in improving the management of advanced thyroid cancers. Molecular tests are classically performed on Formalin-Fixed Paraffin-Embedded (FFPE) carcinoma tissue. However alternative molecular testing strategies are needed when FFPE tumoral tissue is unavailable. The objective of our study was to retrospectively assess the performance of targeted DNA and RNA-based Next Generation Sequencing (NGS) on the fine needle aspirate ...

Background: Radioactive iodine therapy (RAI) is a classical therapeutic approach in patients with differentiated thyroid carcinoma (DCT). Few data are currently available on RAI’s potential impacts on testicular function.Design: A longitudinal prospective multi-center study (PHRC N°P040419) included male patients before a single radioiodine dose of 3.7 GBq of I 131 (V0), at 3 months (V3) and 13 months (V13) post treatment.<p clas...