Searchable abstracts of presentations at key conferences in endocrinology

ea0081p265 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenergic crisis after SARS-COV-2 infection in a patient affected by pheochromocytoma

Novizio Roberto , Emanuele Rizzo Gaetano , Paragliola Rosa Maria , Maggio Ettore , Locantore Pietro , Maria Corsello Salvatore

Background: SARS-CoV-2 infection is characterized by aspecific symptoms (e.g., fever, cough) and can be complicated by viral pneumonia and many other manifestations can occur. Endocrinological complications have also been described. Pheochromocytomas are rare tumors located in the adrenal medulla, causing symptoms due to catecholamines overproduction and abrupt release. Catecholamines release can be continuous or intermittent and there can be several triggers including stress,...

ea0081ep953 | Thyroid | ECE2022

Risk of malignancy of indeterminate thyroid nodules: an Italian single-center cohort study

Cera Gianluca , Novizio Roberto , Corsello Andrea , Rossi Esther Diana , Locantore Pietro , Pontecorvi Alfredo

Background: In 2014 a new Italian classification system of thyroid cytology divided the indeterminate TIR3 category in two groups, TIR3A and TIR3B, aiming to reduce unnecessary thyroidectomies. The reported risk of malignancy is: TIR3A: <10%, suggesting follow-up and possible FNA repetition after 6 months, and TIR3B: 15-30%, recommending surgery.Objectives: We aimed to: evaluate the histological prevalence of malignancy in TIR3A and TIR3B nodules in ...

ea0013p303 | Thyroid | SFEBES2007

W546X mutation of the thyrotropin receptor, cause of subclinical hypothyroidism (SH) in various clinical settings

Locantore Pietro , Evans Carol , Zhang Lei , Warner Justin , Gregory John , John Rhys , Lazarus John , Ludgate Marian

Objectives: Pregnancy and early infancy are periods when increased demand for thyroid hormone can result in subclinical hypothyroidism (SH). SH is frequently a prodrome to autoimmunity, but may be a compensation mechanism for an underlying genetic defect. The W546X mutation of the thyrotropin receptor (TSHR) is present at a frequency of 1 in 180 in a Caucasian population. We aimed to investigate whether W546X was the cause of SH presenting in pregnancy and early infancy.<p...

ea0075a07 | Adrenal gland | EYES2021

Adrenal and pituitary glands involvement by extranodal diffuse large B-cell lymphoma: a case presentation

Ramunno Vittoria , Visconti Felicia , Emanuele Rizzo Gaetano , Corsello Andrea , Maggio Ettore , Menotti Sara , Locantore Pietro

Background: Diffuse large B-cell lymphoma is the most common non-Hodgkin’s lymphoma (NHL). It can involve extranodal sites in about 30%, but the involvement of endocrine organs is rare (adrenal involvement is estimated<0.2%) and correlates with poor prognosis. In contrast to pituitary metastases from solid tumors, NHL involvement of the anterior lobe of the pituitary is more frequently seen.Case presentation: A 84-year-old woman presented to the...

ea0075a12 | Adrenal gland | EYES2021

Evaluation of urinary free cortisol and late night salivary cortisol as diagnostic tools for Cushing’s Syndrome

Novizio Roberto , Locantore Pietro , Mura Chiara , Emanuele Rizzo Gaetano , Ramunno Vittoria , Maria Corsello Salvatore

Background: Cushing’s syndrome (CS) is characterized by inappropriate cortisol secretion and its diagnosis is still challenging for endocrinologist. Nevertheless, CS is a rare condition, making difficult to collect data and establish tests’ diagnostic performances.Objectives: Assessing diagnostic performances of Urinary Free Cortisol (UFC) evaluated by liquid chromatography method coupled with tandem mass (LC-MS/MS) and Late Night Salivary Cort...

ea0075m13 | Metabolic Bone | EYES2021

Hypoparathyroidism after total thyroidectomy in a woman who underwent to bariatric surgery: A case report

Maggio Ettore , Veleno Miriam , Rossi Laura , Novizio Roberto , Emanuele Rizzo Gaetano , Morgante Cesare , Locantore Pietro

Background: Hypoparathyroidism (HypoPT) is characterized by low calcium and parathyroid hormone (PTH), often secondary to thyroid surgery. Treatment consists in activated vitamin D and calcium supplementation. Such treatment may be difficult in patients with malabsorption as calcium usually requires an acid environmental to dissolve, while calcitriol needs an intact intestine for a full absorption.Case report: A 36-year old woman had a history of sleeve ...

ea0075t06 | Thyroid | EYES2021

Ectopic Cushing’s syndrome due to advanced medullary thyroid cancer: a case report

Corsello Andrea , Ramunno Vittoria , Paragliola Rosa Maria , Pacini Giovanni , De Crea Carmela , Raffaelli Marco , Locantore Pietro

Background: Cushing’s syndrome (CS) in medullary thyroid cancer (MTC) is rare with less than 60 cases reported. Less than 1% of MTC develop ectopic ACTH-dependent CS and this correlated with metastasis at diagnosis and poor prognosis.Case presentation: A 32-year-old male was referred to our department for suspected CS. Initial evaluation showed hypokalemia(2.4 mmol/l) and severe ACTH-dependent CS (Cortisol h8:678ng/ml; ACTH:249pg/ml; urinary free co...

ea0041gp238 | Thyroid Cancer (1) | ECE2016

Correlation between basal and stimulated thyroglobulin in differentiated thyroid carcinoma of intermediate and high risk

Senes Paola , De Rosa Annapina , Paragliola Rosa Maria , Papi Giampaolo , Locantore Pietro , Pontecorvi Alfredo , Corsello Salvatore Maria

Thyroglobulin (Tg) is a highly sensitive tumor marker of differentiated thyroid cancer (DTC). To optimize the sensitivity, guidelines recommend Tg measurement after stimulation with recombinant TSH (rh-TSH) 6–12 months after radio remnant ablation (RRA). Based on recent evidence in Literature, it is possible to avoid the measurement of Tg after stimulation with rh-TSH (S-Tg) in presence of undetectable values of basal Tg (B-Tg) if high functional sensitivity (0.1 ng/ml) m...

ea0035p1140 | Thyroid Cancer | ECE2014

Thyroglobulin before radio remnant ablation during levothyroxine withdrawal can be considered an accurate parameter of remission of differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Locantore Pietro , Senes Paola , Prete Alessandro , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: Differentiated thyroid cancer (DTC) is the most frequent endocrine cancer. After surgery followed, if any, by 131I radio remnant ablation (RRA), follow-up monitoring consists of neck ultrasonography (US) and measurements of thyroglobulin (Tg) levels and anti-Tg antibodies (Ac-Tg) both on levothyroxine (L-T4) therapy and after recombinant TSH (rTSH). The aim of our study is to define a cut-off of Tg before RRA (RRA-Tg) during <...

ea0020p516 | Paediatric Endocrinology | ECE2009

Short stature in pediatric Cushing's syndrome: effectiveness of hypercortisolism cure

Paragliola Rosa Maria , Lovicu Rosa Maria , Ingraudo Francesca , Ianni Francesca , Locantore Pietro , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Cushing’s disease (CD) is the most common cause of endogenous Cushing’s syndrome in children and adolescents and represents a rare cause of short stature. A 14-year-old boy came to our attention for progressive weight gain and short stature. Birth length and weight were normal; clinical history was negative for use of glucocorticoids. At examination, height was 140 cm (3th centile), weight was 37.7 kg (10th centile). Tanner stage was: G2, PH 3, testis 3 ml. Hypothyro...