Endocrine Abstracts

Introduction: Microalbuminuria tends to appear in Type 2 diabetes (T2D) and reflecting underlying cardiovascular disease rather than diabetic nephropathy presented at diagnosis. The objective of this study was to evaluate the prevalence of microalbuminuria and its possible relations with T2D, pre-diabetes and hypertension, in a representative sample (n=2860) of the adult population (>18 years old) of Galicia (NW Spain).Material and methods: Subjects ...

Introduction: Atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, regulates several physiologic parameters including diuresis and natriuresis, and lowers arterial, blood pressure.It has been reported that plasma concentrations of ANP rise in response to acute hyperglycaemia in diabetes (1) (2) and this may indicate a neurohormonal response to limit target organ damage (3).We investigate if in situation chr...

Aim: To study the results of transsphenoidal surgery in our Neuroendocrinology Unit in last 10 years.Methods: We reviewed all patients operated in our hospital and followed in our Neuroendocrinology Unit in the last 10 years. We excluded patients with previous surgery or irradiation on this area. We obtained data about type and size of tumor, previous hormonal deficit, local symptoms,complications of surgery and the status after this (remission, persiste...

Aims: To know characteristics and long term evolution of patients with prolactinoma in our Neuroendocrinology Unit.Material and methods: We studied retrospectively all patients with diagnosis of prolactinoma in our Neuroendocrinology Unit in last 12 years.Results: We studied 126 patients. Predominant sex was female (69.07%), 56.7% were macroadenomas. The time from the onset of symptoms until they are seen by the specialist ranges 1...

Introduction: The recombinant GH receptor antagonist pegvisomant (PGV) is actually used for the treatment of acromegaly when surgery and medical therapy with somatostatin analogues (SSA) have failed. Long term safety and effectiveness need to be evaluated.Material and methods: Retrospective analysis of clinical data from all patients treated with pegvisomant in a pituitary disorders unit.Results: Thirteen patients are being treated...

Objective: To report a case of hyperandrogenism attributable to the presence of an ovarian Leydig cell tumor secreting testosterone in a postmenopausal woman.Methods: The laboratory, radiologic, and pathologic findings in our case are described.Results: A 59-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning 5–6 year...

Introduction and objetives: There are few data in literature about the effects of rosuvastatin in patients with familial hypercholesterolemia in Spain. The objective of this study has been:1-to evaluate the efficacy and security of rosuvastatin in patients with familiar hypercholesterolemia2-to test the hypothesis that patients with diabetes have different response to treatment with rosuvastatin.Material and ...

Introduction: Patients with bariatric surgery require close monitoring because of possible metabolic complications. It has been published some cases of severe and persistent hypoglycemias resistant to diet and pharmacologic treatment being necessary a pancreatectomy. We present a case report of nesidioblastosis after gastric bypass that required subtotal pancreatectomy but despite this, hypoglycemias persisted. Before performing total pancreatectomy we placed a tube feeding in...

Ghrelin is a peptide hormone secreted by the stomach with orexigenic properties that induce food intake trough the activation of hypothalamic AMP activated kinase (AMPK). In rodents fed on normal diet the central administration of ghrelin induces an increase in food intake, however, when fed a high fat diet (HFD) rodents are resistant to the orexigenic effect of ghrelin. Recent data show that Cidea interacts with AMPK β-subunit and promotes AMPK degradation trough ubiquit...

Objective: Calculation of accurate insulin boluses is one of the major problems related to intensive insulin regimens. A bolus calculator (BC) incorporated into the insulin pump estimates the dose of insulin to be administered at the meal and makes calculation easier and more precise.The aim of the present study was to assess the efficacy of a BC on glycaemic control of patients with DM1 on CSII.Material and methods: We enrolled 20...