Searchable abstracts of presentations at key conferences in endocrinology

ea0063p62 | Calcium and Bone 1 | ECE2019

The effectiveness of colecalciferol and selective vitamin D receptor agonists treatment on secondary hyperparathyroidism in chronic kidney diseases patients

Egshatyan Lilit , Mokrisheva Natalia , Lutsenko Alexander

Background: Secondary hyperparathyroidism (SHPT) is an early complication of chronic kidney disease (CKD). Maintaining the level of 25(OH)D and parathyroid hormone concentrations in the target range reduce its associated complications (fractures and cardiovascular calcification).Aims: To examine the effectiveness of vitamin D supplementation and selective vitamin D receptor agonists treatment on SHPT in CKD.Materials and methods: P...

ea0063p1117 | Pituitary and Neuroendocrinology 3 | ECE2019

Epidemiology of acromegaly in Russian Federation: evaluation of National registry-based data

Lutsenko Alexander , Przhiyalkovskaya Elena , Pigarova Ekaterina , Belaya Zhanna , Rozhinskaya Liudmila

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...

ea0081ep724 | Pituitary and Neuroendocrinology | ECE2022

Short-term and long-term surgical remission of acromegaly in a tertiary medical center

Lutsenko Alexander , Belaya Zhanna , Przhiyalkovskaya Elena , Rozhinskaya Liudmila , Grigoriev Andrey , Azizyan Vilen , Melnichenko Galina

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

ea0090ep680 | Pituitary and Neuroendocrinology | ECE2023

Clinical features and long-term follow-up of patients with Nelson syndrome: a case series presentation

Lutsenko Alexander , Trukhina Diana , Belaya Zhanna , Przhiyalkovskaya Elena , Dzeranova Larisa , Pigarova Ekaterina , Rozhinskaya Liudmila

Background: Nelson syndrome is a rare complication of Cushing disease (CD), which occurs either in patients with very aggressive CD or as a result of misdiagnosis. Clinical characterization of patients with Nelson syndrome could provide important insights in management of the disorder.Methods: We analyzed medical records of patients with CD between 2015 and 2021 to identify those who developed Nelson syndrome.Results: Nine patients...

ea0090ep687 | Pituitary and Neuroendocrinology | ECE2023

ADH-deficiency (central diabetes insipidus) registry in Russia: current results

Lutsenko Alexander , Pigarova Ekaterina , Dzeranova Larisa , Vikulova Olga , Belaya Zhanna , Rozhinskaya Liudmila , Mokrysheva Natalia , Consortium CDI The

Introduction: ADH-deficiency (central diabetes insipidus, ADH-D) is a rare disease, and data on worldwide and country-specific prevalence rates are scarce. ADH-D registries could provide valuable information on epidemiology, etiological distribution, treatment requirements and potentially serve as a guide for management decisions in clinical practice.Objectives: To assess the epidemiological data on ADH-D in Russian Registry for Central Diabetes Insipidu...

ea0049ep1028 | Pituitary - Clinical | ECE2017

Russian hypothalamic and pituitary tumors registry (OGGO) data analysis: acromegaly

Lutsenko Alexander , Przhiyalkovskaya Elena , Pigarova Ekaterina , Belaya Zhanna , Rozhinskaya Liudmila , Stanoevich Irina

Objective: To analyze registry data on patients with acromegaly.Materials and methods: Russian hypothalamic and pituitary tumors registry database (on-line platform), which contains data on 3719 patients with acromegaly.Results: According to the database, highest prevalence of acromegaly per 100 000 inhabitants is registered in: Penza region (7.3), Kirov region (7.3), Krasnoyarsk region (6.2). Most common clinical presentations in ...

ea0070aep566 | Pituitary and Neuroendocrinology | ECE2020

Plasma microRNA levels in patients with active acromegaly

Lutsenko Alexander , Belaya Zhanna , Nikitin Alexey , Solodovnikov Alexander , Lapshina Anastasia , Przhiyalkovskaya Elena , Melnichenko Galina

Background: Plasma microRNAs (miRs) (miR-4446-3p, miR-215-5p, miR-342-5p) were downregulated in patients with active acromegaly (AM) compared with healthy control subjects as assessed by next-generation sequencing.Aim: The aim of this study wasto validate the previously observed finding in the newly enrolled patients with AM using qRT-PCR.Materials and methods: Morning plasma samples were collected from fasting patients with AM and...

ea0056p764 | Neuroendocrinology | ECE2018

Pregnancy outcomes in women with active acromegaly.

Vorotnikova Svetlana , Tarasova Arina , Pigarova Ekaterina , Lutsenko Alexander , Stanoevich Irina , Dzeranova Larisa

Growth hormone (GH) producing tumors are commonly associated with menstrual disorders and anovulation because of the direct effects of tumor mass on gonadotropins and possible association with hyperprolactinemia. However, some women with acromegaly get pregnant, which rises up a lot of questions about medication, complications and follow-up. We report outcomes of 7 cases of pregnancy in patients with active acromegaly. A median age of patients was 30 years, four of them were w...

ea0056p767 | Neuroendocrinology | ECE2018

Female patients with acromegaly in Russian hypothalamic and pituitary tumors registry (OGGO)

Lutsenko Alexander , Vorotnikova Svetlana , Stanoevich Irina , Przhiyalkovskaya Elena , Pigarova Ekaterina , Rozhinskaya Liudmila , Belaya Zhanna

Aim: To assess the data of the registry concerning women with acromegaly.Materials and methods: Russian hypothalamic and pituitary tumors registry database, containing the information on 3968 acromegalic patients.Results: From all patients with acromegaly registered in the database, 2878 patients (72.5%) are women. We assessed the following data on gonadal status and reproductive function in this group: 512 patients have irregular ...

ea0056p833 | Pituitary - Clinical | ECE2018

Registry for central diabetes insipidus in Russia: prevalence and etiologies of the disease

Pigarova Ekaterina , Dzeranova Larisa , Belaya Zhanna , Rozhinskaya Liudmila , Lutsenko Alexander , Melnichenko Galina , Dedov Ivan , Consortium CDI The

Introduction: Epidemiological data for central diabetes insipidus (CDI) are quite sparse.Objectives: To provide an epidemiological data on CDI in different regions of Russia (20 from 83 Federal regions).Materials and methods: We used the Russian Registry for Central Diabetes Insipidus (RCDI) to study the epidemiological features of CDI.Results: A total of 2004 patients with CDI were recorded, 47% women and 59...