Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps1-01-10 | Cancer | ETA2023

Role of gender on adverse events in a consecutive series of 28 patients with advanced differentiated thyroid cancer receiving lenvatinib

Sapuppo Giulia , Grasso Sonia , Malandrino Pasqualino , Marturano Ilenia , Pellegriti Gabriella

Introduction: The treatment with tyrosine-kinase inhibitor drugs (1st line Lenvatinib) in patients with radioiodine-refractory differentiated thyroid cancer (I-131) and disease progression can be burdened by important side effects which often require suspension/reduction of the therapy and correct multidisciplinary management.Patients and methods: Clinical/histopathological characteristics, outcome, adverse events and the role of gender have been evaluat...

ea0084ps1-03-25 | Thyroid Cancer CLINICAL 1 | ETA2022

Low-intermediate risk thyroid cancer: no benefit of postsurgical iodine?

Tumino Dario , Malandrino Pasqualino , Russo Marco , Piticchio Tommaso , Le Moli Rosario , Frasca Francesco

Objectives: Evaluate the benefit of postsurgical radioactive iodine (RAI) in patients with differentiated thyroid cancer (DTC) at low to intermediate risk of recurrent disease in whom not routinary use of RAI is recommendedMethods: We retrospectively evaluated 1316 patients with DTC diagnosed between 2009-2015. ATA low (LR) and intermediate (IR) risk were included in the study (PTC: tumor size > 1 cm, microscopic extrathyroidal invasion, <5 micro...

ea0092op-06-04 | Oral Session 6: Pregnancy | ETA2023

Changes in TSH suppression during pregnancy reveals novel mechanism for increased thyroid hormone production: comparison between euthyroid and thyroidectomized pregnant women

Scuto Andrea , Tumino Dario , Gambero Federica , Di Benedetto Guenda , Piticchio Tommaso , Malandrino Pasqualino , Frasca Francesco

Objective: Clarify mechanisms determining thyroid homeostasis during pregnancy at hypothalamic-pituitary level.Methods: Retrospective analysis of 251 pregnant women. 220/251 euthyroid without thyroxine therapy (Group 1), 31/251 thyroidectomized under thyroxine replacement therapy (Group 2). Patients under thyroxine replacement therapy with a TSH between 0.4 and 4.0 were included in the study. Patients with combined T3/T4 therapy were excluded.<p clas...

ea0092op-11-01 | Oral Session 11: Autoimmunity / Hyperthyroidism | ETA2023

Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no histological confirm of celiac disease: a meta-analisys

Piticchio Tommaso , Frasca Francesco , Malandrino Pasqualino , Trimboli Pierpaolo , Carrubba Nunzia , Tumminia Andrea , Vinciguerra Federica , Frittitta Lucia

Background: Hashimoto’s thyroiditis (HT) is the most common autoimmune disease worldwide. Prevalence of celiac disease (CD) is higher in HT patients and HT is the most prevalent coexisting disease in CD patients. In the last years, interest about gluten free diet (GFD) has increased for its supposed extraintestinal anti-inflammatory effect, so many patients with HT initiate GFD on their own.Objectives: Aim of this meta-analysis is to examine all qua...

ea0092ps1-02-02 | Graves’ Disease | ETA2023

Predetermined vs calculated 131I activity for the treatment of patients with graves’ disease: which is the best?

Arcidiacono Francesco , Barca Ignazio , Prinzi Antonio , Scuto Andrea , Volpe Salvatore , Piticchio Tommaso , Malandrino Pasqualino , Frasca Francesco , Belfiore Antonino

Background: Graves’ disease (GD) is an autoimmune disorder of thyroid gland and is the first cause of hyperthyroidism. Radioactive iodine (RAI) therapy is the most used second- line treatment after failure of anti-thyroid drugs. The optimal RAI’s activity to be administered may be predetermined or calculated. Whether the latter is better is still a matter of debate.Aim: To compare the risk of persistent hyperthyroidism in GD patients treated wi...

ea0092op-10-03 | Oral Session 10: Novel diagnostics in Thyroid cancer | ETA2023

KI67 proliferative index, but not mitotic count and necrosis, is a prognostic factor in patients with medullary thyroid cancer: a single-center retrospective analysis according to the 2022 who pathological classification

Prinzi Antonio , Bosco Agata , Mirone Alessandro , Tumino Dario , Di Benedetto Guenda , Gambero Federica , Bartoloni Giovanni , Frasca Francesco , Belfiore Antonino , Malandrino Pasqualino

Background: The 2022 WHO Classification of Endocrine and Neuroendocrine Tumors has introduced, as other neuroendocrine neoplasms, new pathological features to classify medullary thyroid carcinoma (MTC) in low/high grade. However, whether it can be reliable in clinical practice should be confirm by further studies.Aim: To verify the predictive value of the 2022 WHO grading system in patients with MTC.Materials and Methods: Tumor tis...

ea0092ps3-29-03 | Treatment 2 | ETA2023

TKIS for advanced thyroid cancer increase tsh levels in thyroidectomized patients: A meta-analysis

Piticchio Tommaso , Belfiore Antonino , Malandrino Pasqualino , Trimboli Pierpaolo , Gambero Federica , Scuto Andrea , Volpe Salvatore , Di Benedetto Guenda , Dario Tumino , Le Moli Rosario , Privitera Grete , Pulvirenti Alfredo , Frasca Francesco

Background: Tyrosine kinase inhibitors (TKIs) are modern antineoplastic molecules widely used in the medical treatment of many cancers including iodine refractory differentiated thyroid carcer (DTC) and advanced medullary thyroid cancer (MTC). In patients with thyroid gland, TKIs frequently cause a destructive and/or autoimmune thyroiditis with consequent hypothyroidism. However, authors have reported unexpected TSH increase or hypothyroidism even in patients with total thyroi...

ea0063p25 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Management of mitotane for advanced adrenocortical carcinoma: a survey in Italy

Puglisi Soraya , Saba Laura , Perotti Paola , Calabrese Anna , Basile Vittoria , Arnaldi Giorgio , Cannavo Salvatore , Stigliano Antonio , Canu Letizia , Loli Paola , Pivonello Rosario , Malandrino Pasqualino , Badalamenti Giuseppe , Torlontano Massimo , Della Casa Silvia , Scaroni Carla , Terzolo Massimo

Background and objective: Mitotane is the main option of treatment for advanced adrenocortical carcinoma (ACC). However, limited evidence is available regarding practical management of mitotane treatment and its eventual combination with chemotherapy or radiotherapy. The aim of the study is to do a survey on the use of mitotane for advanced ACC in expert Italian centers, analyzing data of the LYSOSAFE database.Methods: Retrospective analysis of patients ...

ea0022p416 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Prognostic markers of survival after combined mitotane- and platinum-based chemotherapy in metastatic adrenocortical carcinoma characterized for plasma mitotane level and ERCC1 protein expression analyses

Malandrino Pasqualino , Ghuzlan Abir Al , Castaing Marine , Young Jacques , Caillou Bernard , Travagli Jean-Paul , Elias Dominique , de Baere Thierry , Dromain Clarisse , Chanson Philippe , Schlumberger Martin , Leboulleux Sophie , Baudin Eric

Introduction: Mitotane and platinum-based chemotherapy are the main therapeutic choices for treating inoperable and/or metastatic adrenocortical carcinoma (ACC).Objective: To search for prognostic parameters of survival in patients with metastatic ACC treated with combined mitotane- and platinum-based chemotherapy.Patients: One hundred and thirty one consecutive patients with metastatic ACC treated at the Gustave-Roussy Institute (...

ea0090p381 | Endocrine-related Cancer | ECE2023

Gender related differences in patients with carcinoid syndrome: new insights from a multicenter retrospective study

Grazia Tarsitano Maria , Altieri Barbara , Grossrubatscher Erika , Minotta Roberto , Zamponi Virginia , Albertelli Manuela , Appetecchia Marialuisa , Pia Brizzi Maria , Vittoria Davi Maria , Fanciulli Giuseppe , Giannetta Elisa , Guarnotta Valentina , La Salvia Anna , Lania Andrea , Lavezzi Elisabetta , Malandrino Pasqualino , Mazzilli Rossella , Modica Roberta , Pia Anna , Prinzi Natalie , Pusceddu Sara , Razzore Paula , Zanata Isabella , Chiara Zatelli Maria , Isidori Andrea , Maria Colao Anna , Faggiano Antongiulio , Maddalena Ruggeri Rosaria

The incidence of Neuroendocrine Neoplasm (NEN) and related carcinoid syndrome (CS) increased markedly in recent decades, and women appear to be more at risk than men. As per other tumors, gender may be relevant in influencing the clinical and prognostic characteristics. Unfortunately, there are no studies designed to answer this question in the literature. The present multicentric study was designed to evaluated gender differences, if any, in clinical presentation and outcomes...