Searchable abstracts of presentations at key conferences in endocrinology

ea0090oc2.2 | Oral Communications 2: Thyroid | ECE2023

Faecal microbiota signature in hypothyroid patients with refractoriness to levothyroxine treatment

Virili Camilla , Capriello Silvia , Stramazzo Ilaria , Filardo Simone , Pietro Marisa Di , Sessa Rosa , Centanni Marco

Despite an accurate management, in about 20% of hypothyroid patients showing an increased need for oral levothyroxine (LT4), the leading cause of treatment refractoriness remains unknown. Some studies hypothesized the relationship between gut microbiota composition and thyroid homeostasis, but the possible involvement of microflora in the efficacy of LT4 treatment has not been evaluated yet, and this represents the aim of our study. We examined the faecal microflora compositio...

ea0063p394 | Thyroid 1 | ECE2019

Gastric acidity determines the more appropriate preparation of oral thyroxine

Virili Camilla , Stramazzo Ilaria , Capriello Silvia , Santaguida Maria Giulia , Centanni Marco

Recent reports have proven gastric pH as key for both dissolution and bioavailability of oral thyroxine. This is clinically relevant in patients with gastric disorders to tailor an individualized treatment. In vitro, the softgel preparation of thyroxine possess a superior dissolution profile at increasing pH than the tablet T4. No data are available analyzing the correlation between the gastric pH and the softgel T4 performance in vivo and the present study i...

ea0063p794 | Thyroid 2 | ECE2019

The minimal effective dose of thyroxine is increased in hypothyroid patients with ulcerative colitis

Virili Camilla , Stramazzo Ilaria , Santaguida Maria Giulia , Gargano Lucilla , Centanni Marco

Abstract: Gastrointestinal disorders may impair oral thyroxine (T4) absorption by either affecting the tablet dissolution or adsorbing the hormone in the first tract of intestinal lumen. Ulcerative colitis (UC) is an inflammatory disease whose interference with oral T4 treatment has been suggested but no evidence have been presented so far. This study was aimed at examining the presence of UC and its possible interference in the pharmacologic thyroid homeostasis, in a large co...

ea0049gp221 | Thyroid 3 | ECE2017

Thyroid hormone T3 protects mice from fasting induced skeletal muscle atrophy by counteracting autophagy

Ucci Sarassunta , Russi Valentina , Santaguida Maria Giulia , Centanni Marco , Moresi Viviana , Falzacappa Cecilia Verga

Purpose: Skeletal muscle has been recognized as a thyroid hormones (THs) target for contractile function, regeneration, metabolism and glucose disposal. Despite a role in regulating muscle development has been described, little is known about the role of THs in regulating muscle homeostasis in a pathological state such as food deprivation induced atrophy. The purpose of this study is to evaluate whether thyroid hormones may hamper the fasting induced skeletal muscle atrophy an...

ea0049ep825 | Thyroid (non-cancer) | ECE2017

Thyroid hormone T3 protects skeletal muscle metabolism during fasting in mice

Russi Valentina , Ucci Sarassunta , Virili Camilla , Centanni Marco , Moresi Viviana , Falzacappa Cecilia Verga

Background: Skeletal muscle is known to be a target of THs, regulating oxygen consumption, fiber composition, calcium mobilization and glucose uptake. However, a possible role for THs in muscle homeostasis and cellular metabolism under pathological has never been investigated. Food deprivation induces skeletal muscle atrophy, causing metabolic changes, and forcing the tissue to utilize fatty acid as the main oxidation substrate. Aim of this project was to understand whether T3...

ea0014oc5.5 | Thyroid basic | ECE2007

Transcriptional regulation of human type 2 deiodinase and chorionic gonadotropin genes in human placenta: emerging evidence of a common promoter code

Canettieri Gianluca , Santaguida Maria Giulia , Franchi Antonella , Guardia Michele Della , Gulino Alberto , Centanni Marco

Human type 2 deiodinase (hD2) regulates T3 production in placenta during trophoblast development. hD2 mRNA and protein levels are elevated only during the first trimester of gestation then becoming barely detectable. These variations are similar to those of chorionic gonadotropin (hCG), a well-known marker of early gestation secreted by the cytotrophoblast. A peculiar promoter architecture of the gene encoding the alpha subunit of hCG allows a CRE-mediated synergism between cA...

ea0014p382 | (1) | ECE2007

Increased need for oral thyroxine in total thyroidectomized patients: a prospective analysis

Gargano Lucilla , Virili Camilla , Viceconti Nicola , Santaguida Maria Giulia , Nardo Serena , Centanni Marco

Increasing evidence suggests a relevant role for thyroid gland in maintaining hypophysis-thyroid homeostasis even in patients treated with oral thyroxine. Aim of the study was to compare the daily dose of thyroxine required to attain subnormal serum TSH levels in patients with nontoxic goitre before and following total thyroidectomy. To address this question we have studied: a) 15 patients (8 women and 7 men; median age=53 years) with nontoxic goitre (NTG) and no evidence of a...

ea0056p658 | Female Reproduction | ECE2018

Autoimmune thyroiditis and repeated pregnancy loss: a role for associated autoimmune disorders?

Virili Camilla , Cellini Miriam , Santaguida Maria Giulia , Brusca Nunzia , Stramazzo Ilaria , Gargano Lucilla , Centanni Marco

Repeated pregnancy loss (RPL), defined as two or more spontaneous abortions, may be associated with autoimmune thyroiditis (AT), either isolated or associated with polyautoimmune disorders (PD), which include antiphospholipid syndrome. An increased occurrence of RPL has been reported in patients with isolated AT but very few data are available on the influence of concurrent auto-aggressive disorders on RPL and this represented the aim of our study. A cohort of 1765 consecutive...

ea0084op-05-25 | Oral Session 5: Autoimmunity | ETA2022

Intestinal barrier permeability in patients with hashimoto’s thyroiditis associated to non-endocrine autoimmune disorders

Virili Camilla , Stramazzo Ilaria , Capriello Silvia , Brusca Nunzia , Flavia Bagaglini Maria , Nocella Cristina , Carnevale Roberto , Centanni Marco

Objective: Intestinal barrier (IB) is one of the wider human body surface, whose integrity allows the uptake of nutrients also preserving from the entrance of harmful compounds. An increased permeability of IB, known as “leaky gut”, has been demonstrated in patients with intestinal inflammatory and/or autoimmune disorders as well as in patients with autoimmune diseases involving organs far from the intestine, as in patients with Hashimoto’s thyroiditis (HT). The...

ea0084op-11-53 | Oral Session 11: Young Investigators / Basic | ETA2022

CD3+CD8+CD20+ T cells as a marker of the inflammatory phase in thyroid autoimmune and related polyautoimmune disorders: a pilot study

Stramazzo Ilaria , Virili Camilla , Capriello Silvia , Brusca Nunzia , Flavia Bagaglini Maria , Romeo Giovanna , Mangino Giorgio , Centanni Marco

Objectives: Human CD3+CD20+ T cells represents 3-5% of circulating T cells and may be detected in all lymphatic organs and in the cerebrospinal fluid. In healthy individuals CD3+CD20+ T cells have been shown to produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20- T cells. Some reports described the role of CD3+CD20+ T cells in autoimmune disorders such as multiple scler...