Endocrine Abstracts

Background: Hypothyroidism is a clinical condition caused by a deficiency of thyroid hormones or a decrease in their biological activity. Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricles. Rhythms with frequent and apparently idiopathic PVCs are considered to be a benign condition that can be managed with conservative measures. Beta blockers are considered to be quite effective.Objective: ...

Background: Autoimmune thyroid diseases (AITD) are multifaceted conditions in which the thyroid gland is infiltrated by lymphocytes resulting in the production of thyroid-specific auto-antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb). Iron deficiency (ID) is considered to be the most common nutritional deficiency worldwide and has multiple effects on thyroid metabolism.Aim: The goal of this study is to measure the prevalence of auto...

A 65-year-old patient was hospitalized three times over a two-year period for severe acute pancreatitis. After the first hospitalization, cholecystectomy was performed. During the second hospitalization she was treated in the ICU because of the development of necrotizing emphysematous pancreatitis with the development of sepsis. During the third hospitalization the patient presents clinically with general weakness, agitation, visual hallucinations, disorientation and damaged c...

Background and objective: Human recombinant growth hormone (hrGH/GH) is an injectable medication used commonly for growth hormone deficiency (GHD) and other health conditions that reduce growth and adult height. Daily GH injections can burden families and result in poor adherence. This study was conducted to investigate caregivers’ experiences, attitudes and preferences regarding pediatric GH treatment. At the time of data collection, the long-acting GH products were not ...

Introduction: Liver Steatosis (LS) can be one of the metabolic complications of Cushing Syndrome (CS). The data on the impact of cortisol on liver function are very limited, according to one study the prevalence of LS in CS is 20%. However, the frequency seems to be much higher. Hepatic Steatosis Index (HSI) predicts LS based on ALT, AST, BMI, sex and co-existence of diabetes mellitus/impaired glucose intolerance. It can identify candidates for further liver examinations.<...

Cushing Syndrome (CS) is associated with a 18-fold higher risk of venous thromboembolism (VTE) when compared to the general population with the similar demographic characteristics. Despite numerous studies on hypercoagulability in CS, the unequivocal recommendations regarding timing and dosing of thromboprophylaxis in hypercortisolism are still lacking. We present a case series of patients with CS and VTE, hospitalized in the Endocrinology Department of University Hospital in ...

Background: The Controlled Antenatal Thyroid Screening II (CATS) study, a large randomised trial of thyroxine supplementation for suboptimal gestational thyroid function (SGTF), reported a higher prevalence of elevated attention deficit hyperactivity disorder (ADHD) scores in 9 year-old children exposed to higher thyroid hormone (TH) in utero. Here we investigated if this was accompanied by altered neurodevelopment.Methods: 85 children aged 11-1...

Fatty liver (steatosis) can progress to non-alcoholic fatty liver disease, increasing the risk of diabetes and cardiovascular disease. Growth hormone (GH) deficiency is associated with steatosis, while raising GH reduces steatosis. To date it remains to be determined how GH mediates this hepato-protective effect. To investigate the hepatocyte-specific actions of GH, a mouse model of adult-onset hepatocyte-specific GH receptor knockdown (aHepGHRkd) was generated by treating adu...

Liver autophagy, as assessed by accumulation of LC3-II and p62 proteins, is positively correlated with the severity of nonalcoholic steatohepatitis (NASH) in humans. Since growth hormone (GH) is negatively associated with liver steatosis and NASH development, and our laboratory has reported that steatosis and NASH develops in a mouse model of adult-onset, hepatocyte-specific GH-Receptor knockdown (aHepGHRkd), we sought to determine if GH directly regulates the hepatocyte autop...

Osilodrostat as an inhibitor of adrenal 11B-hydroxylas, is an effective medication used in the management of endogenous hypercortisolism. There are limited data regarding usage of osilodrostat in ectopic Cushing Syndrome (CS). Surgery is usually the first line treatment in ectopic CS, however the source of ectopic hormonal production often remains undiscovered for a long period of time. Meanwhile dangerous state of severe hypercortisolism needs to be managed pharmacologically ...