Endocrine Abstracts

Introduction: Morbid obesity is associated with systemic inflammation, possible impaired glucose toleration and changes in serum lipids. Association of these parameters is risk for atherosclerosis and cardiovascular diseases.Methods: We have analyzed body weight, BMI, lipid profile, glucose, HbA1c and C reactive protein in 36 obese subjects, 8 males and 28 females, 37.9 (±18.6) years of age, before and three monts after bariatric surgery. There was ...

It is supposed a simillar dirnal change of TSH, free fatty acids (FFA) and leptin in humans. Hypothalamic-pituitary-thyroid axis (HPT) is suppressed during food deprivation while there is an elevation of FFA further influencing glucose metabolism. The aim of our study was to investigate whether leptin can act as a metabolic signal linking the adipose tissue metabolism and the HPT. We studied 13 women with polycystic ovary disease-PCOS (mean age: 26.6±1.83 years; BMI: 34...

Different hypothesis exist about the mechanism of glycose control after bariatric surgery involving intestinal bypass. The aim of our study was to determine the insulin and C-peptide response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5 days after gastric by pass surgery. Glycaemia (mmol/l; glucose oxidase), insulin (ECLIA, Roche Diagnostics, pmol/l) and C-peptide (ECLIA, Roche Diagnostics, pmol/l) were det...

Objective: Primary hyperparathyroidism (PHPT) is systemic disease affecting bone metabolism and glucose homeostasis. Patients with PHPT are insulin resistant and have atherogenic dyslipidaemia. Osteocalcin (OC) is bone biomarker associated with increased insulin secretion and insulin sensitivity and decreased visceral fat The aim of our study was to evaluate the body composition and levels of bone biomarkers (osteocalcin and betaCTx), insulin sensitivity and lipids in patients...

Introduction: Adrenal neurilemoma (or schwannoma) are vary rare tumors. They usually present as incidental finding in asymptomatic patients, which makes them dificult to diagnose preoperatively.Case report: We present a 60 year old woman with incidentally discovered adrenal mass of 5 cm on the right side. The tumor was detected by ultrasound and then it was confirmed by MSCT scan. We performed careful endocrine workup. Results showed normal levels of uri...

Introduction: Calcium plays a key role in myocardial contractions and relaxation. Heart failure induced by hypocalcemia is rare but potentially reversible case.Case report: We present the case of 50 years old woman with muscle cramps, cataract, chest pain and dyspnea that lasts 2 years. In regional health center she was treated as psychiatric patient and COPD. Last few months she became extremely malaise with crural edemas and walking distance of 100 m. ...

Introduction: Insulin resistance is quite common among obese individuals. Lifestyle interventions like diet interventions and regular physical activity are still important and safe first-line therapy.The aim of this study was to assess the effects of diet and physical activity-induced weight loss on insulin resistance in extremely obese patients.Methods: Forty-four patients (mean age 41.05±10.23 years) were consecutively recru...

Insulin resistance and/or hyperinsulinemia are risk factors for CVD. Plasma homocysteine is also important risk factor for the development of premature cardiovascular disease (CVD) in type 2 diabetes. The relationship between level of insulin and homocysteine in insulin resistant state is not clear. The aim of our study was to investigate whether plasma homocystein levels are changed by acute hyperinsulinemia and to associate the change of plasma homocysteine with the level of...

Introduction: Adiponectin and its receptors are expressed in human osteoblasts, suggesting that adiponectin may be a hormone linking bone and fat metabolism. In contrast to adiponectin anabolic effect on bone in vitro studies, clinical and animal studies suggest that adiponectin may have negative effects on bone by stimulating the receptor activator of nuclear factor-κB ligand (RANKL) pathway and inhibiting the production of the decoy receptor for RANKL and osteopr...

The antihyperglycaemic drug metformin reduces food consumption through mechanisms that are not fully elucidated. The present study investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin. Rats were injected intracerebroventricularly with ghrelin (5 μg), metformin (50, 100 or 200 μg), AICAR (25 μg) and L-leucine (1 μg) in ...