Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1261 | Thyroid (non-cancer) | ECE2017

Therapeutic options in severe thyrotoxicosis with malabsorption

Stojkovic Mirjana , Savic Slavica , Nedeljkovic-Beleslin Biljana , Ciric Jasmina , Nisic Tanja , Zarkovic Milos

Abstract: A 55-year-old woman was admitted to our hospital due to severe hyperthyreosis. She started to feel symptoms of hyper-metabolism four months prior to hospitalization. At that time she was admitted in regional hospital and had gastroenterological examination because of diarrhea. Crohn’s disease was diagnosed and therapy started. At the same time, thyrosupressive therapy started. She had a history of hyperthyreosis thirteen years ago, duodenal hemorrhage ulcer, hyp...

ea0032p290 | Clinical case reports - Thyroid / Others | ECE2013

Neurogenic hypertension as a case report

Nisic Tanja , Stojkovic Mira , Stojanovic Milos , Ciric Jasmina , Beleslin Biljana , Lalic Tiana , Zarkovic Milos , Trbojevic Bozo

Introduction: Neurogenic hypertension is associated with unilateral neurovascular compression of the brainstem and cranial nerves V, IX-X, VII, VIII. Causes may include nerve injury, vascular compression, tumors. Symptomatology seems hyperactive dysfunction syndrome of the cranial nerves. In the clinical picture, it can be seen trigeminal neuralgia, vertigo, tinnitus, hemifacial spasm, and in some cases hypertension.Case report: Female patient, 45 years ...

ea0032p985 | Thyroid (non-cancer) | ECE2013

Efficacy and safety of combined parenenteral and oral steroid therapy in Graves' orbitopathy

Beleslin Biljana , Ciric Jasmina , Zarkovic Milos , Knezevic Miroslav , Stojkovic Mirjana , Lalic Tijana , Nisic Tanja , Trbojevic Boza

Introduction: Glucocorticoids (GC) are the first line treatment for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined. The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period.Methods: The study includes 50 patients (48±10 years; 37 females) with untreated, active and moderate-to-severe GO. Patient...

ea0032p1051 | Thyroid (non-cancer) | ECE2013

The influence of thyroid hormones on the variability of blood pressure

Nisic Tanja , Stojanovic Milos , Stojkovic Mirjana , Beleslin Biljana , Ciric Jasmina , Lalic Tijana , Trbovic Bozo , Zarkovic Milos

Introduction: Changes in thyroid function have significant impact on the cardiovascular system.Methods: In a group of 37 subjects the level of thyroid hormones FT4, FT3, and TSH were measured. Then carried out short-term analysis for 30 min measureing variability of blood pressure with non-invasive TASK FORCE monitor. Registered data were analyzed by spectral analysis of variability. Statistical analysis were done by Pearson correla...

ea0049ep111 | Clinical case reports - Pituitary/Adrenal | ECE2017

Primary adrenal insufficiency and pregnancy – a case report

Savic Slavica , Stojkovic Mirjana , Nedeljkovic-Beleslin Biljana , Nisic Tanja , Stojanovic Milos , Miletic Marija , Ciric Jasmina , Spremovic-Radjenovic Svetlana , Zarkovic Milos

Primary adrenal insufficiency (PAI) is uncommon in pregnancy. Women with PAI have reduced fertility and parity. If unrecognized or untreated during pregnancy PAI increases risk for maternal and foetal morbiditiy and mortality. Majority of women diagnosed before conception and appropriately treated, have uneventful pregnancies, with increased risk of cesarean section (CS) and preterm delivery.We report a 38-year-old woman with PAI during first spontaneus ...

ea0041ep330 | Clinical case reports - Thyroid/Others | ECE2016

Importance of levothyroxine absorption test in identifying malabsorption as a cause of inadequate substitution for hypothyroidism

Lalic Tijana , Ciric Jasmina , Beleslin Biljana , Stojkovic Mirjana , Savic Slavica , Nisic Tanja , Stojanovic Milos , Barac Marija , Zarkovic Milos

Introduction: The most common cause for persistent elevation of TSH levels in hypothyroid patients treated with levothyroxine is poor compliance. The levothyroxine absorption test (LAT) is usually confirmed this phenomenon called “pseudo-malabsorption”.Case report: Sixty-year-old female, weight 60 kg, BMI 24.3 kg/m2, presented with sleepiness, tiredness, fatigue and forgetfulness. Her skin was very dry and flaky. She had low toleranc...

ea0037ep287 | Calcium and Vitamin D metabolism | ECE2015

Bones in pseudohypoparathyroidism type 1a

Savic Slavica , Nisic Tanja , Lalic Tijana , Nedeljkovic-Beleslin Biljana , Stojkovic Mirjana , Barac Marija , Stojanovic Milos , Ciric Jasmina , Zarkovic Milos

Pseudohypoparathyroidism type 1a (PHP1a) is disorder characterised by resistance to the biological actions of circulating parathyroid hormone (PTH) along with typical features of Albright’s hereditary osteodystrophy (AHO). Tissue-specific imprinting of GNAS gene results in complete resistance to PTH in renal proximale tubule, but skeletal responsiveness to PTH appears intact, since Gαs is biallelically expressed in human bones. The objective of this study was to dete...

ea0037ep937 | Thyroid (non-cancer) | ECE2015

Side effects of steroid therapy in Graves' orbitopathy: comparison of two different protocols: parenteral vs combined parenteral and oral

Beleslin Biljana , Ciric Jasmina , Stojkovic Mirjana , Savic Slavica , Ciric Slavica , Lalic Tijana , Nisic Tanja , Stojanovic Milos , Zarkovic Milos

Introduction: Glucocorticoids (GCs) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined as serious side effects are great concern of GC therapy. The aim of the present study was to evaluate tolerability and safety of two different treatment protocols.Methods: Consecutive patients were divided according to the protocol of GC therapy into two groups: combined intravenous and ...

ea0032p57 | Adrenal cortex | ECE2013

Impact of antihypertensive drugs, sodium intake and potassium plasma concentrations on plasma aldosterone and plasma renin aktivity

Lalic Tijana , Zarkovic Milos , Ciric Jasmina , Beleslin Biljana , Stojkovic Mirjana , Stojanovic Milos , Nisic Tanja , Savic Slavica , Trbojevic Bozo

Introduction: Primary aldosteronism (PA) is a group of disorders which are characterized by inadequate and non-suppressible production of aldosterone. The prevalence of PA is increasing in hypertensive population. The golden standard of screening for primary aldosteronism, determination of aldosterone/plasma renin activity (ARR), is influenced by numerous exogenous and endogenous factors. Testing cannot always be conducted under optimal conditions.Object...

ea0032p620 | Female reproduction | ECE2013

Potential discriminant factors for different pcos phenotypes

Stojkovic Mirjana , Beleslin Biljana , Ciric Jasmina , Savic Slavica , Nisic Tanja , Stojanovic Milos , Lalic Tijana , Trbojevic Bozo , Zarkovic Milos

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is a heterogeneous disorder characterized by oligo- or anovulation (ANOV), biochemical or clinical manifestations of hyperandrogenemia (HA) and polycystic ovaries (PCO). Combination of these three characteristics makes four phenotypes of PCOS: phenotype 1 (ANOV+HA+PCO), phenotype 2 (ANOV+HA), phenotype 3 (HA+PCO) and phenotype 4 (ANOV+PCO). The difference...