Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.14.06 | Diabetes and obesity – Clinical diabetes | ECE2015

Higher HOMA levels and failed decrease in body fat can be considered unfavourable predictors of restoring euglycaemia in diabetic cirrhotic patients undergoing liver transplantation

Grancini Valeria , Lunati Elena , Resi Veronica , Spada Anna , Orsi Emanuela

Introduction: Diabetes mellitus (DM) is a very common complication of cirrhosis (prevalence: 20–60%), primary due to increased hepatic insulin-resistance (IR). After liver transplantation (LT), DM recovers in 67% of cases, while 33% of patients remain diabetic because of a concomitant decreased beta cell function. The roles played by pre-transplant factors determining changes in glucose tolerance after LT are imperfectly known.Aim of the study: To h...

ea0077lb48 | Late Breaking | SFEBES2021

Post-HUS diabetes mellitus in 3 years old child: the challenging management of glucose control and the advantages of SAP therapy initiation

Grancini Valeria , Colosimo Santo , Gaglio Alessia , Resi Veronica , Giarratana Laura , Adinolfi Valerio , Orsi Emanuela

Introduction: Hemolytic-uremic syndrome (HUS) is a clinical condition characterized by nonimmune hemolytic anemia, thrombocytopenia and progressive kidney failure mediated by E.Coli Shiga-like toxin. In rare cases the inflammatory process may lead to beta-cell necrosis and, hence, overt diabetes mellitus. Post-HUS DM is characterized by severe insulin depletion and very high insulin sensitivity, making its therapeutic management particularly challenging....

ea0035p394 | Diabetes (epidemiology, pathophysiology) | ECE2014

Increased prevalence of hepatocellular carcinoma in patients with cirrhosis and insulin resistance candidate to liver transplantation

Grancini Valeria , Lunati Elena , Zimbalatti Dario , Beck-Peccoz Paolo , Orsi Emanuela

Introduction: Hepatocellular carcinoma (HCC) is the first cause of death in patients with cirrhosis, with an incidence of 3–5% per year and a survival of 0–10% 5 years after the diagnosis. Major risk factors for HCC are HCV, HBV infection and alcohol, while a specific cause is not identifiable in 5–30% of cases. Several studies have shown a strong association between metabolic syndrome (MS), characterized by insulin-resistance (IR) and central obesity, and HCC; ...

ea0035p1033 | Thyroid (non-cancer) | ECE2014

Obesity and metabolic syndrome in patients with primary acquired hypothyroidism undergoing chronic LT4 replacement therapy

Manzoni Giuseppina , Martucci Federico , Oltolini Alice , Villa Simona , Zimbalatti Dario , Lattuada Guido , Orsi Emanuela , Perseghin Gianluca

Hypothyroidism is a risk factor for obesity, central adiposity and ectopic fat accumulation. To assess whether this risk could be detected also in stable patients taking regularly the LT4 replacement therapy we assessed retrospectively the prevalence of metabolic syndrome (ATP III definition) and calculated the fatty liver index (FLI) and the visceral adiposity index (VAI) in patients attending our Outpatient Endocrinology Clinic because of known primary acquired hy...

ea0063oc7.1 | Endocrine Connections 1 | ECE2019

Cortisol suppression or peripheral sensitivity and activation are associated with diabetes, hypertension and fragility fractures in postmenopausal eucortisolemic women

Aresta Carmen , Chiodini Iacopo , Gaudio Agostino , Eller-Vainicher Cristina , Morelli Valentina , Zhukouskaya Volha V , Merlotti Daniela , Orsi Emanuela , Barbieri Anna Maria , Fustinoni Silvia , Polledri Elisa , Gennari Luigi , Falchetti Alberto , Carnevale Vincenzo , Persani Luca , Scillitani Alfredo

Background: Cortisol excess is associated with a higher prevalence of hypertension (Hy), type 2 diabetes (T2D) and fragility fractures (FX). A possible association between T2D and fragility FX with the degree of glucocorticoid (GC) suppression and peripheral activation or sensitivity even in non-hypercortisolemic subjects has been previously suggested.Aim: To assess if the degree of GC suppression or peripheral sensitivity and activation are associated w...

ea0070aep1005 | Hot topics (including COVID-19) | ECE2020

Adrenal insufficiency at the time of COVID-19: A retrospective study

Carosi Giulia , Morelli Valentina , Del Sindaco Giulia , Cremaschi Arianna , Frigerio Sofia , Rodari Giulia , Indirli Rita , Liliana Serban Andreea , Profka Eriselda , Mungari Roberta , Resi Veronica , Orsi Emanuela , Ferrante Emanuele , Dolci Alessia , Giavoli Claudia , Arosio Maura , Mantovani Giovanna

Background: COVID-19 represents a global health emergency and infected patients with chronic diseases often present a severe impairment. Adrenal insufficiency (AI) is supposed to be associated with an increased risk of infections which could trigger adrenal crisis. Our primary aim was to evaluate the incidence of COVID-19 symptoms and complications in AI patients.Materials and methods: We conducted a retrospective case-control study, in 279 patients with...