Searchable abstracts of presentations at key conferences in endocrinology

ea0081p52 | Calcium and Bone | ECE2022

Atherothrombotic risk in subjects with parathyroid disorders: cross-sectional study

Naciu Anda Mihaela , Tabacco Gaia , Piccirillo Francesco , Mattia Viscusi Michele , Di Tommaso Alfonso Maria , Sterpetti Giulia , Palermo Andrea , Nusca Annunziata

Background: Clinical and molecular findings have shown that parathyroid hormone (PTH) affects the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Furthermore, the endothelium is a recognised target tissue of PTH and there is an increasing body of evidence that PTH affects functional and structural properties of arteries. Patients with chronic post-surgical hypoparathyroidism (hypoPT) have higher incidence...

ea0081ep588 | Endocrine-Related Cancer | ECE2022

Severe refractory nonislet cell tumor hypoglycemia and paraneoplastic hypercalcemia in a patient with pancreatic adenocarcinoma with neuroendocrine differentiation: a case report.

Rossini Giovanni , Tommaso Alfonso Maria Di , Rausa Donatella , Palermo Andrea , Tuccinardi Dario , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Nonislet cell tumor hypoglycemia (NICTH) is a rare complication of malignancy characterized by overproduction of incompletely processed IGF-2 and subsequent stimulation of insulin receptors and increased glucose utilization. We report a patient with pancreatic adenocarcinoma with neuroendocrine differentiation who presented with NICTH and paraneoplastic hypercalcemia. A 51 year-old male was admitted to the ER for altered mental status and confusion. His blood glucose was 27 mg...

ea0073aep627 | Thyroid | ECE2021

Laser ablation versus radiofrequency ablation for benign non-functioning thyroid nodules: twelve-month results of a randomized, parallel-arm, open-label trial

Cesareo Roberto , Manfrini Silvia , Pasqualini Valerio , Ambrogi Cesare , Sanson Gianfranco , Gallo Andrea , Pozzilli Paolo , Pedone Claudio , Crescenzi Anna , Palermo Andrea

BackgroundRadiofrequency ablation (RFA) seems to achieve a significantly larger nodule volume reduction rate (VRR) than laser ablation (LA) in benign non-functioning thyroid nodules (BNTNs). We compared the efficacy and safety of both thermal ablation treatments at the 12-month follow-up in patients with solid or predominantly solid BNTN.MethodsThis 12-month, single-use, randomized open-label parallel trial c...

ea0070oc7.6 | Endocrine-related Cancer | ECE2020

Llaser ablation vs radiofrequency ablation for benign non-functioning thyroid nodules: six-month results of a randomised, parallel, open-label, trial (LARA trial)

Cesareo Roberto , Maurizio Pacella Claudio , Pasqualini Valerio , Campagna Giuseppe , Lauria Pantano Angelo , Pozzilli Paolo , Cianni Roberto , Manfrini Silvia , Crescenzi Anna , Palermo Andrea

Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed to compare the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN.Methods: This six-month, single-use, randomized open label parallel trial compared the following primary endpoints between the RFA and LA groups six months after treatmen...

ea0056gp265 | Thyroid non cancer - Benign Thyroid disease/ treatment | ECE2018

Nodule size as predictive factor of efficacy of radiofrequency ablation in treating autonomously functioning thyroid nodules

Palermo Andrea , Naciu Anda Mihaela , Iozzino Mario , Pasqualini Valerio , Simeoni Carla , Manfrini Silvia , Tabacco Gaia , Casini Alessandro , Campagna Giuseppe , Cesareo Roberto

Background: Radiofrequency ablation(RFA) has been advocated as an alternative to radioiodine and/or surgery for the treatment of autonomously functioning benign thyroid nodule (AFTN). However, only a few studies have investigated the efficacy of RFA on AFTN. Furthermore, these studies are characterized by several biases about patient selection, number of RFA treatments, short clinical and radiographic follow-up. A recent prospective 12-month study has demonstrated that one sin...

ea0073aep104 | Calcium and Bone | ECE2021

Evaluation of bone quality by dxa-based bone strain index in primary hyperparathyroidism

Tabacco Gaia , Naciu Anda Mihaela , Messina Carmelo , Rinaudo Luca , Cesareo Roberto , Falcone Stefania , Manfrini Silvia , Napoli Nicola , Bilezikian John , Ulivieri Fabio Massimo , Palermo Andrea

BackgroudPrimary hyperparathyroidism (PHPT) is associated with impaired bone quality and increased fracture risk. Reliable tools for the evaluation of bone quality parameters are not yet clinically available. Bone Strain Index (BSI) is a new metric for bone strength based on Finite Element Analysis from lumbar spine and femoral neck dual X-ray absorptiometry images.AimTo assess the lumbar spine (LS), femoral ...

ea0081rc3.2 | Rapid Communications 3: Thyroid 1 | ECE2022

Performance of a raman fingerprint in thyroid nodules with indeterminate cytology: a prospective blinded monocentric study

Palermo Andrea , Sodo Armida , Mihaela Naciu Anda , Di Gioacchino Michael , Paolucci Alessio , Di Masi Alessandra , Maggi Daria , Crucitti Pierfilippo , Longo Filippo , Perrella Eleonora , Taffon Chiara , Verri Martina , Antonietta Ricci Maria , Crescenzi Anna

Background: Molecular analysis of thyroid fine-needle aspiration biopsy (FNA) was proposed to improve indeterminate nodules management. However, sensibility and specificity as well as the cost of molecular diagnostics require to be improved to increase their cost-effectiveness for medical practice setting. Raman spectroscopy (RS) demonstrated ability in separating benign from malignant thyroid lesions in surgically removed tissues, based on specific RS profile. This study aime...

ea0081rc8.6 | Rapid Communications 8: Calcium and Bone | ECE2022

Health related quality of life in adults with hypoparathyroidism in an exploratory analysis of the phase 2 PaTH forward trial of TransCon PTH

Palermo Andrea , Vokes Tamara J , Khan Aliya , Rubin Mishaela , Schwarz Peter , Clarke Bart L , Eriksen Erik , Marcocci Claudio , Pagotto Uberto , Tsourdi Elena , Sikjaer Tanja , Brod Meryl , Mcleod Lori , Markova Denka , Noori Wahidullah , Eng Walter Frank , Shu Aimee , Smith Alden

Background: Patients with hypoparathyroidism experience significant physical and cognitive symptoms and reduced health-related quality of life (HRQoL). Conventional therapy for hypoparathyroidism does not fully alleviate diminished HRQoL. The Hypoparathyroidism Patient Experience Scales (HPES) were developed to assess disease-specific physical and cognitive symptoms as well as the impact of hypoparathyroidsm on HRQol. TransCon PTH, an investigational long-acting prodrug of par...

ea0063gp20 | Calcium and Bone 1 | ECE2019

Clinical, biochemical and radiological profile of normocalcaemic hyperparathyroidism: a multicentric cross-sectional evaluation

Naciu Anda Mihaela , Tabacco Gaia , Falcone Stefania , Santonati Assunta , Maggi Daria , D'Onofrio Luca , Briganti Silvia Irina , Castellitto Domenico , Casini Alessandro , Pedone Claudio , Fabbri Andrea , Napoli Nicola , Pozzilli Paolo , Manfrini Silvia , Cesareo Roberto , Palermo Andrea

Background: The normocalcaemic hyperparathyroidism (NHPT) has been defined as a condition with persistently normal total and ionized calcium levels in the presence of high levels of PTH. The clinical aspects of NHPT have been evaluated in different cohorts but the interpretation of these findings is confounded by differing methods used to rule out secondary hyperparathyroidism and by the small number of NHPT subjects enrolled. Up to now, there is no information available that ...

ea0070oc6.5 | Hot Topics (including COVID-19 | ECE2020

TransCon PTH, a long-acting PTH, in patients with hypoparathyroidism: Results of the phase 2 PaTH forward trial

Sikjaer Tanja , Rejnmark Lars , Khan Aliya , Schwarz Peter , Vokes Tamara , Clarke Bart , Rubin Mishaela , Hofbauer Lorenz , Eriksen Erik , Palermo Andrea , Pagotto Uberto , Marcocci Claudio , Ahmed Intekhab , Mourya Sanchita , Markova Denka , Karpf David B

Background: Hypoparathyroidism (HP) is characterized by low serum calcium (sCa) and high serum phosphate (sP). Standard of care (SoC), active vitamin D and calcium, raises sCa and sP and increases burden of illness on HP patients by worsening hypercalciuria and the CaxP product. Parathyroid hormone (PTH)(1–84)(t1/2 ~2–3 hrs) is approved and can raise sCa and allow partial withdrawal of SoC, but does not sufficiently control urine calcium or symptoma...