Endocrine Abstracts

Introduction: Pheochromocytomasand paragangliomas are tumors derived from chromaffin cells which result from mutations of at least six different genes as autosomal dominant disorders.Aim: To evaluate the existence of correlations between genetic alterations and clinical data in 16 patients with pheochromocytomas and/or paragangliomas.Methods: From 2007 to 2009, 13 patients with pheochromocytoma [3 men, medium age 39 years (14&#8211...

Cell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomere maintenance due to the ‘alternative mechanism of telomere lengthening’ it was advanced that such immortalization could be due to telomerase reactivation, but the mechanisms underlying such reactivation remained elusive.Mutations in the coding region of telomerase gene are very rare in the cancer setting, despite being associated with...

Background: Graves’ Disease (GD) is one of the most common organ specific autoimmune disorders, being characterized by an abnormal production of stimulating autoantibodies to the thyrotropin receptor (TSHR). Some studies demonstrated that genetic polymorphisms in certain cytokines, namely interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), are associated with a greater susceptibility of developing GD. Our aim was to evaluate ...

After almost 3 years since SARS-CoV-2infection was detected for the first time, knowledge about its repercussions on the thyroid gland function in the course of acute illness or in the post-COVID-19 are still poorly understood. This gland may be particularly susceptible to SARS-CoV-2 as this coronavirus enters cells through ACE-2 receptors, which are largely expressed in the thyroid gland. Through an observational, longitudinal and retrospective study, we investigated the seru...

Objective: Graves’ Disease (GD) is one of the most common autoimmune disorders. Some SNP in pro-inflammatory cytokines have already been linked to an increased susceptibility of developing GD. Thyroid hormones are crucial modulators of lipid metabolism. A pro-inflammatory state, may contribute several metabolic changes, including disturbances in lipid metabolism. Our aim was to evaluate if SNP in pro-inflammatory cytokines also contribute to disturbances of lipid profile ...

Angiotensin-converting enzyme 2 (ACE2), Transmembrane serine protease 2 (TMPRSS2) and Furin were known to be key players for the SARS-CoV-2 infection. Thyroid gland was shown to be one of the relevant targets for SARS-CoV-2 infection allegedly due to the higher expression levels of these molecules in follicular cells. However, it remains to be fully determined the expression of ACE2, TMPRSS2 and Furin in normal follicular cell. In addition, the putative role of these molecules...

Introduction: The management of small size (≤ 1 cm) papillary thyroid carcinoma, also known as papillary thyroid microcarcinoma (PTMC) is a debated topic as it includes tumors with a wide range of biological characteristics and behavior.Objectives: To describe prevalence, clinical and histological characteristics of PTMC with excellent response to treatment after a median follow up of 9.85±6.21 years.Methods: We did a re...

Objective: While the genetic repertoire of papillary thyroid carcinomas (PTCs) and poorly differentiated thyroid carcinomas (PDTCs) is well documented, there is a considerable lack of molecular profiling in the metastases of these tumors. Hence, we aim at performing a meticulous molecular profiling of metastatic PTCs and PDTCs.Methods: We retrieved and analyzed the molecular and clinical features of 136 metastatic PTCs and 33 metastatic PDTCs subjected t...

Introduction and objectives: Papillary Thyroid Carcinoma (PTC) accounts for 84% of all thyroid cancers and has shown increasing incidence in recent decades. The greater availability of imaging studies and fine needle cytology partly explains this phenomenon. However, the rising incidence of advanced-stage thyroid carcinomas suggests that this trend may be partially due to a change in the biological behaviour of these tumours. In recent years, evidence has grown indicating that...

Objectives: Hürthle cell (oncocytic) lesions can be metaplastic or neoplastic events. The neoplastic entities -formerly, oncocytic variant of follicular tumours; Hürthle cell neoplasm (HCN) - include HC adenomas and HC carcinomas and have been recognized as a separate class of tumours by the WHO. The remaining of the thyroid tumours demonstrating “mitochondrion-rich cells” and oncocytic morphology are referred under the umbrella term of “oncocytic vari...