Endocrine Abstracts

In the work-up for primary aldosteronism (PA) adrenal venous sampling (AVS) is a corner stone. Although challenged during recent years by means of being insensitive and invasive, it remains the so far only method for lateralization of PA. Indeed, omission of AVS in young patients with a clear adrenal nodule on a CT scan, and development of noninvasive alternatives using positron emission tomography (PET), may replace AVS in certain subgroups. A review of the curent status of A...

Autoimmune diseases tend to coexist in the same subjects and are more often present in women than in men. Finland has the highest incidence of type 1 diabetes (TID). However, the coexistence of autoimmune diseases and excess risk compared to individuals without T1D in unknown. This study compares the proportion of autoimmune hypothyreosis and hyperthyreosis, Addison’s disease and celiac disease in adults in Finland with and without T1D. The study included 4,758 patients w...

Introduction: Phaeochromocytomas often induce hyperglycaemia. Few cases are reported with hypoglycaemic fits. The mechanism is unknown. Our findings may indicate a mechanism.The patient: A 37 year old female had a phaeochromocytoma, with typical characteristics: attacks of headache, nausea and sweating. High blood pressures, up to 237/134. Electrocardiogram indicated ischemia, normal coronary arteries on dynamic CT, normal Echo-Doppler heart examination....

Background: The growth hormone system (growth hormone, GH and insulin-like-growth-factor I, IGF-I) might be implicated in congestive heart failure (CHF). In experimental models IGF-I increases cardiac contractility and reduces apoptosis of myocytes exposed to ischemic injury. In clinical studies GH-therapy has been used in CHF. One previous population based investigation showed that low levels of IGF-I was associated with an increased incidence of CHF. The result of this inves...

Background: Increased alcohol intake is associated with several health disorders. However, its impact on body composition is still controversial and data regarding this subject in people with type 1 diabetes (T1D) are limited. We have shown that central obesity is associated with diabetes complications in T1D, and now, we investigated whether the alcohol consumption is associated with body fat distribution in adults with T1D from the Finnish Diabetic Nephropathy (FinnDiane) St...

Objectives: Lonapegsomatropin (SKYTROFA; TransCon hGH), a prodrug of somatropin, is approved by the EMA and FDA for once-weekly treatment of pediatric growth hormone deficiency (GHD). Lonapegsomatropin uses TransCon® technology, which combines a parent drug transiently linked to an inert carrier to achieve sustained release. The characterization of anti-drug antibodies (ADAs) was assessed in 3 phase 3 trials of lonapegsomatropin in pediatric GHD.Met...

Background and Objective: Information on the long-term effects of anabolic androgenic steroids (AAS) use on the myocellular properties of human skeletal muscle is scarce, despite being the primary target of AAS. Animal studies suggest persistence of upregulated myonuclei numbers following AAS discontinuation. Few human studies have investigated the effects of AAS on human skeletal muscle cell morphology and exclusively focused on current AAS users. No data exist elucidating th...

Background: The purpose of this study was to register the frequency and cause of method-dependent interference in the Roche thyroid immunoassays observed in our laboratory.Methods: Serum samples to confirm discordant thyroid results were collected from June 2013 to September 2018, in samples sent to the Hormone Laboratory, Oslo University Hospital. The laboratory serves as a reference laboratory on thyroid diseases for about 2/3 of the inhabitants of Nor...

Background: We have previously shown that LC-MS/MS analyses of steroid hormones are superior to immunoassays monitoring 21OHD, due to better specificity and the possibility to multiplexing several steroid hormones in the same assay. This may lead to better understanding of the individual steroid hormone profile in patients with CAH. Here we present four patients cases with the same genotype in the CYP21A2 gene, and evaluate their steroid profile by LC-MS/MS analyses.<...

Pheochromocytoma is a rare disease but frequently poses a diagnostic dilemma due to the unspecific symptoms and its potentially life-threatening nature. There is a perception of an increase in the incidence of pheocromocytomas in recent years, but no data on time trends exist. We obtained data from The Danish National Registry of Patients, The Danish Registry of Causes of Death, and The National Pathology Registry for all persons registered with pheochromocytoma in 1977–2...