Searchable abstracts of presentations at key conferences in endocrinology

ea0090s1.3 | Spotlight on posterior pituitary | ECE2023

Tolvaptan for hyponatremia in cancer

Peri Alessandro

Hyponatremia is the most common electrolyte disorder in hospitalized patients, including cancer patients. Multiple causes can lead to hyponatremia, but frequently this electrolyte disorder is due to the syndrome of inappropriate antidiuresis (SIAD). In cancer patients this syndrome is mostly secondary to ectopic secretion of arginine vasopressin by tumoral cells. In addition, several chemotherapeutic drugs induce the release of arginine vasopressin by the hypothalamus. There i...

ea0022s27.1 | Multifaceted aspects of neuroprotection | ECE2010

Relationship between oestrogen and cholesterol in neuroprotection

Peri Alessandro

Alzheimer’s disease (AD), the most common neurodegenerative disease associated with ageing, is still an incurable condition. Although in vitro evidence strongly indicates that oestrogen exerts neurotrophic and neuroprotective effects, the role of this class of hormones in the treatment of AD is still a debated issue. In 2000 a new gene, named seladin-1 (for Selective Alzheimer’s Disease indicator-1), was identified and found to be down regulated in vuln...

ea0081p435 | Pituitary and Neuroendocrinology | ECE2022

Liver steatosis in an in vivo model of hyponatremia secondary to SIAD

Marroncini Giada , Naldi Laura , Ancheschi Cecilia , Fibbi Benedetta , Peri Alessandro

Hyponatremia is the most frequent electrolytic disorder in clinical practice. It is estimated that in about 50% of cases hyponatremia is secondary to the syndrome of inappropriate antidiuresis (SIAD). Hyponatremia is associated with a worse outcome and with increased mortality in several diseases, including cancer. In vitro and in vivo evidence shows that low [Na+ ] is associated with neurological and extra-neurological alterations, which include f...

ea0037ep285 | Calcium and Vitamin D metabolism | ECE2015

Low extracellular sodium promotes adipogenic commitment of human mesenchymal stromal cells: a novel mechanism for chronic hyponatremia-induced bone loss

Deledda Cristiana , Fibbi Benedetta , Giuliani Corinna , Benvenuti Susanna , Luciani Paola , Mazzanti Benedetta , Saccardi Riccardo , Peri Alessandro

Hyponatraemia represents an independent risk factor for osteoporosis and fractures, affecting both bone density and quality. A direct stimulation of osteoclastogenesis and bone resorption in the presence of reduced extracellular sodium concentrations ([Na+]) has been shown, but, to date, the effects of reduced [Na+] on osteoblasts have not been elucidated. This study investigated the effects of a chronic reduction of extracellular [Na+], independently of osmotic stress, on hum...

ea0032oc1.6 | Pituitary & Molecular Endocrinology | ECE2013

Management of euvolemic hyponatremia attributed to SIADH in the hospital: interim results from a prospective, observational, multi-center, global registry

Peri Alessandro , Verbalis Joseph , Greenberg Arthur , Johannsson Gudmundur , Ball Steven , Jorgensen Jens Otto , Chiodo Joseph

Introduction: Hyponatremia (HN) is the most common electrolyte disorder of hospitalized patients (pts). It occurs in up to 28% of in-pts, increases the in hospital risk of death by 1.47 fold, and is associated with significantly higher mortality risk following discharge. The HN Registry is the first large scale, international effort to document the clinical characteristics, treatments used, and impact of HN in hospital settings.Methods: After informed co...

ea0032p623 | Growth hormome IGF axis – basic | ECE2013

Low extracellular sodium causes neuronal distress independently of reduced osmolality in an experimental model of chronic hyponatremia

Deledda Cristiana , Luciani Paola , Benvenuti Susanna , Modi Giulia , Bossio Alessandro , Giuliani Corinna , Fibbi Benedetta , Peri Alessandro

Introduction: There is evidence that chronic mild hyponatremia (serum (Na+) 130–135 mmol/l) may have clinical consequences, such as fracture occurrence and neurological symptoms including unsteadiness, falls and attention deficits. These have been traditionally associated to water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts negative effects on human neuronal...

ea0032p864 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Moderate hyponatremia is associated with an increased risk of overall mortality: a comprehensive meta-analysis

Corona Giovanni , Giuliani Corinna , Parenti Gabriele , Norello Dario , Verbalis Joseph G , Forti Gianni , Maggi Mario , Peri Alessandro

Introduction: Hyponatremia is the most common electrolyte disorder in clinical practice, and evidence to date indicates that severe hyponatremia is associated with increased morbidity and mortality. The aim of our study was to perform a comprehensive meta-analysis that included all the published studies that compared mortality rates in subjects with or without hyponatremia of any degree.Methods: An extensive Medline, Embase, and Cochrane search was perfo...

ea0016oc1.7 | Neuroendocrinology and pituitary | ECE2008

Intermittent high glucose concentrations reduce neuronal precursor proliferation by altering the IGF system: the involvement of the neuroprotective factor seladin-1

Giannini Stefano , Pezzatini Anna , Luciani Paola , Manuelli Cinzia , Benvenuti Susanna , Cellai Ilaria , Deledda Cristiana , Vannelli Gabriella Barbara , Rotella Carlo Maria , Serio Mario , Peri Alessandro

The exposure of cells to high glucose concentrations is considered a determinant of diabetic neuropathy. Conversely, members of the Insulin-like Growth Factor (IGF) system are well known neurotrophic factors. Here, we investigated the effects of constant and intermittent high glucose concentrations on IGF-I and IGF Binding Proteins (IGFBPs) in human neuroblast long-term cell cultures (FNC). We first demonstrated that FNC express the IGF-I receptor, and express and release in t...

ea0014p530 | (1) | ECE2007

The expression of the neuroprotective factor seladin-1 is up-regulated by thyroid hormones in human neuronal precursor cells, but not in mature neurons

Benvenuti Susanna , Luciani Paola , Cellai Ilaria , Deledda Cristiana , Saccardi Riccardo , Urbani Serena , Vannelli Gabriella B , Francini Fabio , Squecco Roberta , Serio Mario , Pinchera Aldo , Peri Alessandro

Thyroid hormones (TH) play a fundamental role during brain development by modulating the expression of different genes involved in neuronal differentiation, proliferation, migration, myelinization, and synapse formation. Seladin-1 (for SELective Alzheimer’s Disease INdicator-1) is a recently identified anti-apoptotic gene, which has been found to be down-regulated in brain regions affected by Alzheimer’s disease (AD). We hypothesized that seladin-1 might be a ...

ea0026p247 | Pituitary | ECE2011

A multicenter study on acromegalic patients treated with pegvisomant monotherapy or with pegvisomant plus somatostatin analogues: role of exon 3 deleted GH receptor polymorfism

Filopanti Marcello , Olgiati Luca , Lania Andrea , Beck-Peccoz Paolo , De Marinis Laura , Grottoli Silvia , Martini Chiara , Cannavo Salvatore , Bogazzi Fausto , Ferone Diego , Arnaldi Giorgio , Peri Alessandro , Tita Patrizia , Pigliaru Francesca , Angeletti Gabriella , Jaffrain-Rea Marie-Lise , Losa Marco , Spada Anna

Introduction: To date, two pharmacogenetic studies investigated the effect of the common exon 3 deletion of GH receptor (d3-GHR) variant in small series of acromegalic patients treated with Pegvisomant (Peg), suggesting an association of d3-GHR allele with better response to Peg.Aim: To assess the influence of d3-GHR variant in a large cohort of acromegalics with active disease and resistance to somatostatin analogues (SSA) treated with either Peg monoth...