Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1119 | Neuroendocrinology | ICEECE2012

Ghrelin, leptin and adiponectin plasma levels in narcolepsy with cataplexy

Lakocevic M. , Petakov M. , Barisic M. , Radosavljevic B. , Antic J. , Damjanovic S.

Introduction: Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness and REM-sleep abnormalities. Lateral hypothalamic hypocretin/orexin neurones are critical for normal wakefulness and energy expenditure, and the reduction of their activity has been linked with narcolepsy. Their activity is inhibited by extracellular glucose and the ‘satiety’ hormone leptin but stimulated by the ’hunger’ hormone ghrelin. Patients with narcolepsy ...

ea0029p1249 | Obesity | ICEECE2012

Serum leptin levels in patients with type 1 gaucher disease

Petakov M. , Suvajdzic N. , Lakocevic M. , Petakov M. , Ognjanovic S. , Isailovic T. , Macut D. , Djurovic M. , Elezovic V. , Popovic B. , Bozic I. , Bogavac T. , Damjanovic S.

Introduction: Leptin is an adipocyte-secreted hormone that plays a key part in energy homeostasis but also regulates reproductive, neuroendocrine, immune, and metabolic functions. Inflammatory cytokines may affect leptin secretion. Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues. The pathology of Gaucher disease pr...

ea0007p170 | Reproduction | BES2004

Leptin, inhibin B and LH levels in patients with anorexia nervosa

Djurovic M , Pekic S , Cetkovic A , Doknic M , Petakov M , Damjanovic S , Zivkovic V , Dieguez C , Casanueva F , Popovic V

Inhibin B is a product of the gonads and it is a marker for ovarian follicular development. We studied leptin, inhibin B and LH levels in two groups of patients with AN, at low weight (n=20, BMI=14.3 plus/minus 0.3 kg/m2) and after they reached goal weight and restore menstrual cycles (n=13, BMI 19.3 plus/minus 1.0 kg/m2). Nineteen eumenorrheic females (BMI 19.8 plus/minus 0.4 kg/m2) served as controls. At low weight in patients with AN, basal leptin (1.1 plus/minus 0.2 ng/L),...

ea0005p183 | Neuroendocrinology and Behaviour | BES2003

Serum leptin, insulin, IGF-1 levels and body composition in partially and fully recovered patients with anorexia nervosa

Djurovic M , Petakov M , Damjanovic S , Pekic S , Glisic B , Miljic D , Doknic M , Dieguez C , Casanueva F , Popovic V

The variables which might affect the reproductive function in recovered patients with anorexia nervosa (AN) were investigated. We studied 12 patients with partially (n=6) and fully recovered AN (n= 6). They were matched for age (22.5 plus/minus 1.8 vs. 23.2 plus/minus 1.7 yrs; p>0.05), body weight (50.3 plus/minus 2.1 vs. 56.7 plus/minus 2.3kg; p>0.05) and BMI (19.7 plus/minus 0.2 vs. 20.3 plus/minus 0.6 kg/m2, p>0.05). Partially recovered AN were amenorrhoeic while f...

ea0008p20 | Cytokines and growth factors | SFE2004

Low circulating ghrelin levels in gastrectomized patients do not affect the growth hormone response to insulin induced hypoglycemia

Miljic D , Pekic S , Pesko P , Djurovic M , Doknic M , Petakov M , Damjanovic S , Micic D , Cvijovic G , Diguez C , Casanueva FF , Popovic V

Ghrelin is a potent growth hormone (GH) secretagogue in rats and in humans. Since stomach is the main source of circulating ghrelin, gastrectomy reduces plasma ghrelin concentrations by 65%. The implications of decreased circulating ghrelin on GH secretion have not yet been investigated. Furthermore, the neuroendocrine pathways through which ghrelin acts to release GH are largely unknown. We aimed to investigate GH response after insulin induced hypoglycemia (ITT) and after sy...

ea0029p1696 | Thyroid (non-cancer) | ICEECE2012

Thyroid concentrations and leptin levels in patients with anorexia nervosa

Nikolic Djurovic M. , Jankovic D. , Petakov M. , Antic J. , Damjanovic S.

Anorexia nervosa (AN) is known as a state of gonadotrophin and leptin deficiency. Leptin, the product of OB gene, secreted by adipocytes, is proved to play an important role in regulating apetite and energy expenditure. Thyroid hormones are Important regulators of total energy expenditure are thyroid hormones and also are able to increase oxygen consumption by tissues. The aim of the study was to evaluate a possible interaction of thyroid hormones (T3, T4...

ea0026p108 | Female reproduction | ECE2011

Relation of insulin resistance and lipid peroxidation in non-obese women with polycystic ovary syndrome

Macut D , Lissounov A , Bozic I , Simic T , Bjekic J , Petakov M , Damjanovic S , Savic-Radojevic A

Introduction: Polycystic ovary syndrome (PCOS) is a frequent metabolic disorder in women of the reproductive age, and is characterized by multi-factorial cardiovascular risk factors. Insulin resistance is proposed as a central factor linking PCOS to increasing risk of cardiovascular disease. The aim of our study was to explore a link between insulin resistance and oxidative stress, as a predictor of cardiovascular risk, in young, non-obese PCOS women.Met...

ea0026p183 | Neuroendocrinology | ECE2011

Hipothalamo–pituitary–adrenal axis function in posttraumatic stress disorder

Bozic I , Macut D , Popovic B , Isailovic T , Petakov M , Ognjanovic S , Bogavac T , Damjanovic S

Introduction: Posttraumatic stress disorder (PTSD) is anxious disorder that occurs following exposure to trauma. In the last two decades, numerous studies showed that dysregulation of hipothalamo–pituitary–adrenal axis (HPAA) is a core feature of the PTSD. Still, results are heterogeneous and often conflicted with one another. Therefore, we conducted strictly controlled study in order to characterize relationship between ACTH and cortisol secretion in patients with c...

ea0011p395 | Diabetes, metabolism and cardiovascular | ECE2006

Insulin sensitivity and lipid profile in obese and normal weight hypertensive subjects

Ognjanovic S , Petakov M , Macut Dj , Isailovic T , Popovic B , Bozic I , Damjanovic S

The aim of this study was to compare metabolic profile in hypertensive obese and lean subjects. The study population consisted of 76 patients. We measured fasting glucose and insulin levels, triglycerides, total, LDL and HDL cholesterol. We also estimated the BMI, WHR, systolic (SBP) and diastolic blood pressure (DBP). We used WHO criteria for abdominal obesity (WHR>0.90 men, >0.85 women), and WHO criteria for diagnosing the metabolic syndrome (triglyceride>1.7 mmo...

ea0007p121 | Endocrine tumours and neoplasia | BES2004

Discrepancies between current consensus criteria for cure after transsphenoidal surgery for acromegaly

Petakov M , Djurovic M , Miljic D , Doknic M , Pekic S , Popovic V , Damjanovic S

The short-term results of transsphenoidal surgery as initial treatment for acromegaly were analyzed according to consensus defining the criteria for cure of acromegaly.Thirty nine newly diagnosed patients with acromegaly (20 females and 19 males, mean age 46.9 plus/minus 1.4 years, range 29-66 yrs), underwent transsphenoidal pituitary adenomectomy by the same neursurgeon. Patients have been assessed postoperatively at 8 weeks (GH after 75 g oral glucose ...