Searchable abstracts of presentations at key conferences in endocrinology

ea0048o7 | Oral Communications | SFEEU2017

Hypertestosteronemia and primary infertility due to an extragonadal germ cell tumor of the anterior mediastinum

Dimitriadis Georgios K , Kaltsas Gregory , Randeva Harpal S

A 26-year-old Caucasian male presented to the joint infertility outpatients clinic with primary infertility. His medical history included hypertrophic cardiomyopathy (HCM) due to genetically confirmed MYH7 sarcomere protein mutation, treated with implantable cardioverter-defibrillator while his partner was a healthy 24-year-old Caucasian nulliparous female. Initial investigations showed hypertestosteronemia (Testosterone: >51.0 nmol/l) and azoospermia, hence the c...

ea0050p336 | Obesity and Metabolism | SFEBES2017

Metabolic phenotype of Male Obesity-associated Secondary Hypogonadism pre- and post-replacement therapy with intra-muscular Testosterone undecanoate therapy

Dimitriadis Georgios K , Randeva Harpal S , Grammatopoulos Dimitris K , Barber Thomas M

Aim: To explore the metabolic phenotype of Male Obesity-associated Secondary Hypogonadism (MOSH) and following treatment with long-acting intramuscular (IM) testosterone undecanoate.Methods: A prospective observational pilot study on metabolic effects of IM testosterone undecanoate in MOSH (Hypogonadal [HG] group, n=13), including baseline comparisons with controls (Eugonadal [EG] group, n=15). Half the subj...

ea0050p336 | Obesity and Metabolism | SFEBES2017

Metabolic phenotype of Male Obesity-associated Secondary Hypogonadism pre- and post-replacement therapy with intra-muscular Testosterone undecanoate therapy

Dimitriadis Georgios K , Randeva Harpal S , Grammatopoulos Dimitris K , Barber Thomas M

Aim: To explore the metabolic phenotype of Male Obesity-associated Secondary Hypogonadism (MOSH) and following treatment with long-acting intramuscular (IM) testosterone undecanoate.Methods: A prospective observational pilot study on metabolic effects of IM testosterone undecanoate in MOSH (Hypogonadal [HG] group, n=13), including baseline comparisons with controls (Eugonadal [EG] group, n=15). Half the subj...

ea0016p500 | Obesity | ECE2008

Retinol-binding protein 4 (RBP-4) levels do not change after oral glucose tolerance test in obese and overweight individuals, but correlate with some indices of insulin resistance

Lewandowski Krzysztof C , Basinska-Lewandowska Magdalena , Bienkiewicz Malgorzata , Randeva Harpal S , Lewinski Andrzej

Background: Secretory products from adipocytes may contribute to increased insulin resistance (IR). Retinol-binding protein-4 (RBP-4) may increase IR in mice, with elevated levels in insulin resistant mice and humans with obesity and type 2 diabetes. Mechanisms regulating RBP-4 synthesis remain not fully understood. It is not clear whether short-term hyperglycaemia alters RBP-4 levels in humans. In order to investigate this, we measured serum RBP-4 concentrations during 75 gra...

ea0016p534 | Obesity | ECE2008

Insulin and glucose regulates omentin-1, a novel adipokine: relation to women with the polycyastic ovary synfrome

Tan Bee K , Adya Raghu , Farhatullah S , Lewandowski KC , O'Hare Paul , Lehnert Hendrik , Randeva Harpal S

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Recent studies have shown that plasma omentin-1 levels decrease with obesity. Currently, no data exists on the relative expression and regulation of omentin-1 in adipose tissue (AT) of PCOS women.Objectives: To assess mRNA and protein levels of omentin-1 in omental (om) AT of PCOS women and matched controls, including circulating omentin-1. Ex vivo and in vivo</...

ea0014p71 | (1) | ECE2007

Raised serum, adipocyte and adipose tissue retinol binding protein 4 (RBP4) in women with polycystic ovary syndrome

Tan Bee Kang , Chen Jing , Pua Sheryl , Richard Kennedy C , Randeva Harpal S

Context: Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and obesity, both predisposing factors to type 2 diabetes. A very recently described adipokine, retinol-binding protein 4 (RBP-4), has been shown to modulate insulin signalling and possibly lead to IR. At present, there is no data that depict the relative expression of RBP-4 in either serum or adipose tissue of PCOS women.Objectives: In women with PCOS compared to matche...

ea0050p224 | Diabetes and Cardiovascular | SFEBES2017

UHCW audit on SGLT2 inhibitor (SGLT2-i) use

Mytilinaiou Maria , Dimitriadis Georgios K , Davasgaium Allan , Sambrook Diane , Hewins Claire , Nalawade Nilisha , Grammatopoulos Dimitris K , Randeva Harpal S

Aim: After almost 2 centuries, SGLT2-i have made their comeback in human pharmacology through successful re-introduction in diabetes type 2 (T2D). Via restriction of renal glucose reabsorption, SGLT2-i have shown promising results. The aim of this audit was to ensure that current practice at UHCW NHS Trust is in line with the agreed national standards, whilst collecting clinical data from the use of SGLT2-i.Methods: This...

ea0050ep061 | Neoplasia, Cancer and Late Effects | SFEBES2017

Hypertestosteronemia and primary infertility from a mediastinal extragonadal germ cell tumor

Dimitriadis Georgios K , Mytilinaiou Maria , Davasgaium Allan , Sambrook Diane , Drakou Eftychia E , Hewins Claire , Nalawade Nilisha , Randeva Harpal S

A 26-year-old Caucasian male presented to the joint infertility outpatients clinic with primary infertility. His medical history included hypertrophic cardiomyopathy (HCM) due to genetically confirmed MYH7 sarcomere protein mutation, treated with implantable cardioverter-defibrillator while his partner was a healthy 24-year-old Caucasian nulliparous female. Initial investigations showed hypertestosteronemia (Testosterone: >...

ea0050p224 | Diabetes and Cardiovascular | SFEBES2017

UHCW audit on SGLT2 inhibitor (SGLT2-i) use

Mytilinaiou Maria , Dimitriadis Georgios K , Davasgaium Allan , Sambrook Diane , Hewins Claire , Nalawade Nilisha , Grammatopoulos Dimitris K , Randeva Harpal S

Aim: After almost 2 centuries, SGLT2-i have made their comeback in human pharmacology through successful re-introduction in diabetes type 2 (T2D). Via restriction of renal glucose reabsorption, SGLT2-i have shown promising results. The aim of this audit was to ensure that current practice at UHCW NHS Trust is in line with the agreed national standards, whilst collecting clinical data from the use of SGLT2-i.Methods: This...

ea0050ep061 | Neoplasia, Cancer and Late Effects | SFEBES2017

Hypertestosteronemia and primary infertility from a mediastinal extragonadal germ cell tumor

Dimitriadis Georgios K , Mytilinaiou Maria , Davasgaium Allan , Sambrook Diane , Drakou Eftychia E , Hewins Claire , Nalawade Nilisha , Randeva Harpal S

A 26-year-old Caucasian male presented to the joint infertility outpatients clinic with primary infertility. His medical history included hypertrophic cardiomyopathy (HCM) due to genetically confirmed MYH7 sarcomere protein mutation, treated with implantable cardioverter-defibrillator while his partner was a healthy 24-year-old Caucasian nulliparous female. Initial investigations showed hypertestosteronemia (Testosterone: >...