Endocrine Abstracts

Background: RhGH treatment in adults with childhood onset growth hormone deficiency (COGHD) affect bone metabolism over time according to gender and age. A long-term study of bone mass density (BMD) in young-middle age hypopituitary patients with COGHD may better highlight possible benefits of therapy and improve clinical follow up.Methods: We enrolled 40 adults (age range during follow-up: 16.8–36 years, F: 38%) with COGHD with at least 20 years o...

Background: Pasireotide LAR is a multireceptor targeted somatostatin analogue that has been shown to obtain a better biochemical control of acromegaly. However, pasireotide LAR could induce hyperglycemia in acromegalic patients with higher baseline glucose values. The devices that can track interstitial glucose levels such as continuous glucose monitoring (CGM) could be a useful for studying the impact of SSA on patients’ glucose status.Aim: We aime...

Background: Pegvisomant (PEG) is a second line medical treatment for active acromegalic patients. PEG efficacy is between 61.5 and 92% and even if it is administered daily its long half-life suggests a possible use with a non-daily regime.Aim: We aim to compare acromegalic patients on daily PEG administration (DP) with patients on non-daily PEG administration (NDP).Methods: We studied 43 acromegalic patients under PEG treatment bet...

Introduction: Acromegalic cardiomyopathy is characterized by myocardial hypertrophy and interstitial myocardial fibrosis at biopsy. We studied left ventricular hypertrophy -LVH- through echocardiography (-ECHO- 2-D standard echocardiography and Doppler analysis) and cardiac magnetic resonance (CMR) analysis. Myocardial fibrosis was studied with late enhancement technique (LE) and extracellular volume technique (ECV) at CMR.Methods: 25 patients -pts- (13 ...

Background: Hyperandrogenism and disrupted folliculogenesis are prominent features of polycystic ovary syndrome (PCOS) and are causatively linked to ovarian dysfunction. In PCOS, increased anti-Müllerian hormone (AMH) serum levels have been observed and related to the severity of the phenotype. However, the regulation of AMH in PCOS remains poorly understood. Therefore, we compared AMH secretory pattern after acute exposure to a GnRH-analogue in women affected by PCOS or ...

Introduction: Epidemiological studies indicate that patients with acromegaly have increased mortality rates for cardiovascular and cerebrovascular disease (CVD). Potentials risk factors for increased CVD include hypopituitarism and cranial radiation therapy (CRT).Case Report: A 43-year-old acromegalic woman was admitted because of worsening headache, left lower facial numbness and left arm weakness. Two weeks later she developed a central palsy of the le...