Searchable abstracts of presentations at key conferences in endocrinology

ea0090mte10 | Advantages and disadvantages of surgery, radioactive iodine, and long-term anti-thyroid drug therapy for Graves' hyperthyroidism | ECE2023

Advantages and disadvantages of surgery, radioactive iodine, and long-term anti-thyroid drug therapy for Graves’ hyperthyroidism

Ruchala Marek

Graves’ disease (GD) is an autoimmune thyroid disorder being the most frequent cause of hyperthyroidism in iodine-sufficient countries. There are three main ways to treat GD: pharmacotherapy, radioiodine treatment (RAI) and thyroidectomy. During the lecture certain advantages and disadvantages of those three methods will be discussed. Advantages of anti-thyroid drugs (ATDs) include their immunosuppressive action and outpatient therapy. Disadvantages are higher relapse rat...

ea0035s10.2 | Difficulties in the treatment of Graves orbitopathy | ECE2014

Radiotherapy in Graves’ orbitopathy: current status

Ruchala Marek

Treatment of Graves’ orbitopathy (GO) remains a diagnostic and therapeutic challenge for clinicians all over the world. The elimination of risk factors, like encouraging smoking cessation, achieving euthyroidism and local measures usage are the most important and usually sufficient treatment methods in most mild cases. A course of selenium may also be beneficial. High-dose i.v. glucocorticosteroids remain the first-line therapy in moderate-to-severe orbitopathy, however i...

ea0035p982 | Thyroid (non-cancer) | ECE2014

Treatment of severe thyroid function disorders and observed changes in body composition

Stangierski Adam , Guzik Przemyslaw , Ruchala Marek

Hyper- and hypothyroidism are accompanied by significant changes in basic metabolic rate, balance of catabolic and anabolic processes, thermogenesis and ultimately in body weight. The aim of this pilot study was to estimate changes in body composition during certain stages of treatment in patients with severe hypo- and hyperthyroidism; current relation between observed hormonal status and body composition and ultimately the relation between changes in body composition and chan...

ea0035p996 | Thyroid (non-cancer) | ECE2014

Irisin – newly discovered adipo-myokine and its association with thyroid function – preliminary study

Zybek Ariadna , Szczepanek-Parulska Ewelina , Ruchala Marek

Introduction: Irisin is a recently reported adipo-myokine. To date, many researchers underline its significant influence on the body metabolism and thermogenesis. Secreted by muscle and adipose tissue irisin promotes a program of subcutaneous white adipose tissue ‘browning’. As a result, heat production and general energy expenditure raise. Irisin is considered to be a potential mediator of the health-promoting role of physical exercises. Its possible compensatory ro...

ea0070aep123 | Bone and Calcium | ECE2020

Usefulness of parathormone (PTH) needle washout measurement vs MIBI scintiscan in localization of parathyroid adenoma- a single--center based preliminary study

Filipowicz Dorota , Szczepanek-Parulska Ewelina , Ruchala Marek

Introduction: An accurate identification of affected parathyroid is crucial for implementation of mini-invasive surgery techniques and therefore reduction of complication rate. A few centers postulate measuring washout parathormone (PTH)concentrationin suspected lesions, despite lack of established cut-off point for concentration values and validated measurement methods. Thisprospective study aimed to compare washout PTH assessment vs MIBI scintiscan in terms of efficacy in lo...

ea0056p880 | Pituitary - Clinical | ECE2018

Usefulness of stereotactic radiotherapy in acromegalic patient resistant to conventional treatment

Brominska Barbara , Komarowska Hanna , Ruchala Marek

Introduction: Acromegaly is a rare, chronic disease characterized by increased secretion of growth hormone, most commonly by autonomous adenoma of the anterior pituitary. Mortality is 2–3 times higher than in general population. So that, it is vital to achieve biochemical cure. We present a case in which patient was successfully treated with stereotactic radiotherapy (SRT)- CyberKnife and preserved pituitary function.Case report: A 39-years old men ...

ea0037ep625 | Obesity and cardiovascular endocrinology | ECE2015

The body distribution of iodine-125 labeled irisin in 10-week-old rats: preliminary data

Zybek Ariadna , Trejter Marcin , Zabel Maciej , Ruchala Marek

Introduction: Irisin is a newly discovered adipo-myokine, that has a significant influence on body metabolism. Available data about this peptide is still insufficient. The aim of the study is to provide some initial information about body distribution of irisin in rats.Methods: The studied group consisted of 27 10-week-old female Wistar rats, which received intraperitoneally ~0.7 mcCi of iodine-125 labeled irisin. The studied rats were divided on five su...

ea0037ep792 | Pituitary: clinical | ECE2015

Thyroid lesions in patients with acromegaly–case-control study

Wolinski Kosma , Stangierski Adam , Gurgul Edyta , Brominska Barbara , Ruchala Marek

Introduction: Acromegaly is a disease caused by excessive secretion of growth hormone and subsequently insulin growth factor 1. It is believed that this oversecretion can cause increased prevalence of nodular goiter and thyroid cancer. However, the amount of studies comparing acromegalic patients with control groups is low. The aim of the study was to assess the prevalence of thyroid lesions in patients with acromegaly in comparison with age and sex-matched control group.<...

ea0037ep955 | Thyroid (non-cancer) | ECE2015

Shear-wave elastography in diagnostics of primary hyperparathyroidism – new application of the method

Stangierski Adam , Wolinski Kosma , Szczepanek-Parulska Ewelina , Ruchala Marek

Introduction: Shear wave elastography (SWE) is a reliable, objective and reproducible technique in sonographic assessment of tissue stiffness. It is considered to be an improvement of conventional ultrasonographic examination. It was demonstrated to be useful in the diagnosis of many thyroid disorders, such as thyroid cancer, Hashimoto’s thyroiditis or Graves’ disease. The aim of our study was to check if SWE can be supportive in the diagnosis of primary hyperparathy...

ea0037ep1120 | Endocrine tumours | ECE2015

The prevalence of benign and malignant neoplasms in the patients with acromegaly

Stangierski Adam , Wolinski Kosma , Gurgul Edyta , Ruchala Marek

Introduction: Acromegaly is a relatively rare endocrine condition caused by GH oversecretion by pituitary adenoma. Its most frequent complications include cardiovascular and respiratory system diseases with high tendency of neoplastic transformation and increased risk of benign and malignant tumors. The aim of this retrospective study was to assess the prevalence of benign and malignant neoplasms in patients with acromegaly.Materials and methods: We have...