Searchable abstracts of presentations at key conferences in endocrinology

ea0063p186 | Diabetes, Obesity and Metabolism 1 | ECE2019

Relationship between cortisoluria and the presence of metabolic syndrome among HIV-infected patients

Guerreiro Vanessa , Sergio Joao , Serrao Rosario , Sarmento Antonio , Carvalho Davide , Freitas Paula

Introduction: People living with human immunodeficiency virus (HIV) are at increased risk of developing metabolic disorders, such as obesity, dyslipidemia, insulin resistance, diabetes and hypertension; which may also be associated with hypercortisolism. Due to the similarity between the metabolic changes present in these two clinical situations, several studies have evaluated whether HIV-infected patients have increased levels of cortisol, but the results are not consensual. ...

ea0037ep641 | Obesity and cardiovascular endocrinology | ECE2015

Body composition in HIV-infected patients under combined antiretroviral therapy over 5 years

Grenha Ines , Oliveira Joana , Lau Eva , Vieira Romana , Serrao Rosario , Sarmento Antonio , Carvalho Davide , Freitas Paula

Introduction: HIV infection and combined antiretroviral therapy (cART) have been associated with lipodistrophy and changes in body composition. However, there are few studies on body composition evolution of HIV-infected patients, under cART.Aims: To evaluate the evolution of body composition in HIV-1 infected patients under cART over 5 years.Methods: Retrospective, observational study in a cohort of HIV-infected patients on cART. ...

ea0056p607 | Obesity | ECE2018

Prevalence of obesity in a population of patients with HIV: relationship with clinical lipodistrophy, effect of sex, age, viral replication, duration of disease and cart

Guerreiro Vanessa , Neves Joao , Serrao Rosario , Sarmento Antonio , Carvalho David , Freitas Paula

Introduction: Adipose tissue disturbances (lipodystrophy and obesity) are prevalent in patients infected with HIV. Our aims were to evaluate the prevalence of obesity and the association with lipodystrophy, the effect of gender, age, viral replication, duration of disease and cART in a population of HIV patients under cART.Methods: In this retrospective study, 580 patients were included. The characteristics of the population are presented through percent...

ea0090p364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Metformin Ameliorates Fatty Liver Disease in A High-Fat Diet-Induced Obese FVB/N Mouse Model

Lozano de la Haba Samanta , Herman-Sanchez Natalia , Ojeda Perez Betsaida , Garcia-Estrada Antonio , Sarmento-Cabral Andre , M Luque Raul , Gahete Manuel D.

Objectives: Previous studies have shown that metformin can reduce high-fat diet (HFD)-induced body weight gain and fat accumulation in the liver. However, the results obtained in animal models regarding the implication of metformin in the modulation of other whole-body and tissue-specific parameters, are controversial or need to be further explored. Consequently, we aimed to explore the capacity of metformin in modulating glucose/insulin metabolism, liver function, adiposity, ...

ea0090p389 | Endocrine-related Cancer | ECE2023

Therapeutic potential of the splicing factor SRSF6 as a novel regulator of the Androgen Receptor in prostate cancer

Montero-Hidalgo Antonio J. , Gomez-Gomez Enrique , Saez-Martinez Prudencio , Fuentes-Fayos Antonio C. , Sanchez-Sanchez Rafael , Olmos David , Jesus Martinez-Fuentes Antonio , Sarmento-Cabral Andre , Gahete Manuel D. , Manuel Jimenez Vacas Juan , M Luque Raul

Background: Prostate cancer (PCa) is the fifth leading cause of cancer-related death worldwide. The main pharmacological strategy for this pathology is the blockade of the androgen receptor signalling pathway, commonly known as androgen-deprivation therapy. However, some of the patients does no longer respond to this hormonal therapy. Therefore, finding novel therapeutic strategies to tackle PCa, especially its most advanced phenotype [i.e., castration-resistant prostate cance...