Endocrine Abstracts

Objective: We aimed to compare the effectiveness of F-18 fluorodeoxyglucose in positron emission computed tomography (FDG-PET/CT) findings under elevated TSH levels (eTSH) and suppressed TSH levels (sTSH) in differentiated thyroid carcinoma patients with TENIS syndrome (Thyroglobulin-elevated Negative Iodine Scintigraphy).Methods: A total of 23 patients with differentiated thyroid carcinoma (DTC) who undergone total thyroidectomy and 131I ablation therap...

Aldosterone is the main steroid hormone controlling sodium homeostasis in human. During the neonatal period, full term newborns and more specifically premature infants, are subjected to an impaired renal capacity to reabsorb sodium, responsible for sodium loss and failure to thrive which could be linked to a renal aldosterone unresponsiveness at birth. A clinical prospective study on 50 newborns and their mothers, revealed high aldosterone and renin levels in umbilical blood s...

Pituitary infarctions are not unknown in patients with pituitary tumours. We describe here a 39-year-old lady, who presented with a history of sudden onset severe headache without any restriction of her visual fields. She had features of acromegaly with enlarged hand and feet size, progressive deepening of her voice and coarsening of facial features over the preceding year. She also had a euthyroid multinodular goitre. CT scan and MRI of the pituitary gland suggested cystic de...

Aim and Introduction: Peripheral giant cell granulomas (PHDG) are uncommon exophytic lesions of the oral cavity that originate from the periosteum or periodontal membrane as a polypoid mass. Mandibular involvement is more common than maxillary involvement. Patients with primary hyperparathyroidism can infrequently exhibit PHDG in the early stages of the disease. We wanted to present our case who was examined for giant cell granuloma developing in the mandibula and was found to...

Renal and cardio-vascular complications of prematurity are well established, notably those associated with renal tubular immaturity, responsible for major salt loss at birth, as well as early hypertension in adulthood. However, the molecular underlying mechanisms remain poorly understood. Our objective was to investigate the impact of preterm birth on the ontogenesis of renal corticosteroid pathways, to evaluate its implication on perinatal complications and on the emergence o...

The Mineralocorticoid Receptor (MR), a hormone-activated transcription factor that mediates sodium-retaining action of aldosterone, is highly expressed in the distal nephron in which large variations in extracellular fluid tonicity are generated by the cortico-papillary gradient. However, mechanisms regulating MR expression remain sparse. We recently showed that extracellular tonicity modulates renal MR expression through posttranscriptional mechanisms (Viengchareun, Mol Endoc...

Objective: Orexin-A and orexin-B and their G-protein coupled receptors (orexin receptor-1 & -2: OX1R, OX2R) have divergent effects on physiological behaviour, cardiovascular regulation, glucocorticoid and insulin release. Furthermore, orexins have been shown to affect both brown adipose tissue energy expenditure and thermogenesis through stimulation of sympathetic nerve activity. Despite in vivo studies demonstrating a role for orexins acting centrally on adipose ti...

Objective: Orexin-A and orexin-B and their G-protein coupled receptors (orexin receptor-1 & -2: OX1R, OX2R) have divergent effects on physiological behaviour, cardiovascular regulation, glucocorticoid and insulin release. Furthermore, orexins have been shown to affect both brown adipose tissue energy expenditure and thermogenesis through stimulation of sympathetic nerve activity. Despite in vivo studies demonstrating a role for orexins acting centrally on adipose ti...

Introduction: Radioiodine-resistant thyroid carcinoma is an important milestone in the treatment and follow-up of thyroid cancers. The biological defects of iodine uptake in thyroid cancer cells should be well known. In this study, we aimed to evaluate the clinical and pathological features and SLC5A5 gene expression status of iodine-refractory papillary thyroid carcinoma patients. Material-Method: We studied SLC5A5 expression in 83 papillary thyroid car...

Introduction: The incidence of papillary thyroid cancer (PTC) in the coexistence of Graves’ disease (GD) and thyroid nodule is not known clearly, and the pathophysiology of PTC development in these patients is still unclear. Aim: The aim of our study is to compare the clinicopathological features of GD patients with thyroid nodule + PTC and patients with euthyroid and non auto-immune thyroid nodule + PTC and investigate the clinicopathological featu...