Endocrine Abstracts

Background: D hypovitaminosis and primary hyperparathyroidism frequently coexist. Secondary hyperparathyroidism reactive to D hypovitaminosis is difficult to be differentiated from primary hyperparthyroidism.Aims: To differentiate patients with D hypovitaminosis and secondary hyperparathyroidism.Materials and methods: Prospective study involving 71 patients admitted in our department for 1 year with the initial diagnosis of primary...

We present the case of a 40 year old man presenting at first consultation an ‘idiopathic’ fast-onset and severe polyuro-polydipsic syndrome (diuresis of 10 l/24 hours, with urine osmolality of less than 50 mOsm/kg and urine gravity lower than 1001). Clinical examination showed pallor and decreased pilosity at an asthenic patient with limited lesions of vitiligo and loss of libido. Water deprivation test showed the persistence of excretion of highly diluted amounts of...

Topical application of corticosteroids is frequently used in the therapy of various dermatological diseases due to their antiinflammatory and immunsuppressive effects. Systemic pharmacological levels of glucocorticoids lead, on the other hand, to Cushing syndrome, i.e. significant modifications of intermediary metabolism, body composition, bone mass, haematolymphopoietic system and, last but not least, to skin modifications: purple striae, petechiae, infections. We describe a ...

Aim of the study: Assessing prevalence and severity of erectile dysfunction in patients with pituitary diseases.Materials and methods: International Index of Erectile Function (IIEF) and Sexual Health Inventory for Men (SHIM) questionnaires were used to assess erectile dysfunction (ED) in 83 patients having pituitary diseases (31 patients had hypopituitarism, 11 diabetes insipidus, 10 prolactinomas, 11 nonfunctional adenomas, 16 operated acromegaly, 4 GH...

We describe two very rare genetic diseases characterized by particular physical features and deviation from normal growth. The first patient, CM, was admitted for delayed growth (113 cm at 8 years of age, -3 S.D.). The child had short lower arms with small hands and clinodactyly of the fifth finger. He had round widely spaced eyes with long eyelashes, a flat profile and prominent forehead, short upturned nose, misaligned teeth and gum hypertrophy. We diagnosed a...

Topical application of corticosteroids is frequently used in the therapy of dermatological diseases due to their anti-inflammatory and immunosuppressive effects. On the other hand, when reaching pharmacological levels, exogenous corticoids frequently lead to complete Cushing syndrome, including skin modifications, irrespective of the route of administration. We describe four cases of iatrogenic Cushing’s syndrome triggered by topical application of corticoids. The first t...

It is known that thyroid pathology is generally more frequently found in women than in men. The somatotroph axis stimulates skeleton growth, but also the development of smooth tissues, including the thyroid gland. We investigated the effect of chronic GH excess upon ultrasound-evaluated (7.5 MHz linear probe) thyroid gland morphology of 74 patients (40 women şi 34 men) diagnosed with acromegaly. When compared to mean thyroid volume of age- and sex-matched non-acromegali...

Until 2002 less than 200 cases of primary hyperparathyroidism identified during pregnancy were reported. We present a case of primary hyperparathyroidism discovered during pregnancy in a 28-year-old woman. The disease was suspected due to a hypercalcemia discovered during a routine blood assessment during pregnancy (calcium=11 mg/dl, phosphorus=2.4 mg/dl). The patient was investigated in the Clinic of Endocrinology and the diagnosis of primary hyperparathyroidism was made on b...

Introduction: Acromegaly is a rare, complex condition that throughout its evolution affects the body on numerous levels, especially if inappropriately managed. Some of the complications it develops over time are ophthalmic, neurological and psychiatric.Aim: The aim is to asses the impact of long-term acromegaly on the eye, nervous system and mental health of previously diagnosed patients.Patients and method: 90 patients’ recor...

Background: Vitamin D deficiency is frequently associated with primary hyperparathyroidism, but the impact of this association on disease evolution and complications is ill defined. Aims: to assess the role of vitamin D status on the metabolic profile and spectrum of complications at patients with primary hyperparathyroidism.Materials and methods: Transversal study involving 42 patients with primary hyperparathyroidism submitted to parathyroidectomy. We ...