Endocrine Abstracts

Electron transfer mediated by proteins is a key process in nature.Many of the proteins involved in such electron transfers are complex and may require a number of redox active cofactors. In addition the electron-transfer steps themselves may add to the complexity by being coupled to other processes such as proton transfer and re-organisational changes. This is the case in the cytochromes P450 that function as steroidogenic enzymes. In fact, these enzymes...

Background: The aim of this study was to explore if evaluation of lipid risk factors like lipoprotein(a) (Lp(a)) and conventional lipid profile parameters can be a efficient predictor of the cardiovascular risk in the patients of diabetes.Methods: Sixty individuals with angiographically proven premature CAD and 30 healthy individuals matched for age and sex were studied a tertiary health care center, New Delhi, India, over a period of 18 months. CAD pati...

Background: Lipoprotein-associated phospholipase A2 (LpPLA2) is known as an emerging marker of coronary artery disease (CAD). However its role and levels have not been documented clearly in diabetic patients with CAD in Indians. The aim of this study was to explore the association of LpplA2 levels between diabetic and non-diabetic patients with CAD and compare it with other established markers like hs-CRP.Methods: Sixty individuals with angiographically ...

Carcinoid tumours are the most common neuroendocrine tumors with an estimated incidence of 7-13/ million population. The clinical symptoms of carcinoid tumours usually relate to presence of the carcinoid syndrome, local symptoms or metastases. Most are asymptomatic with only 10% manifesting the 'carcinoid syndrome'. We report an 86 year-old lady referred for evaluation of multiple subcutaneous, nodules around her neck and upper back, with a suspicion of underlying lymphoprolif...

Background: Adreno cortical carcinoma (ACC) is a rare malignancy associated with aggressive biological behavior and poor outcome. The reported incidence in literature is about approximately two cases per million population’s.These tumors might be functional or non-functional depending on their ability to secrete various adrenocortical hormones. ACC occurring in children and adults show distinct characteristics and there is not much literature regarding the differences. Si...

Background: Diabetes mellitus or more appropriately type 2 diabetes mellitus (T2DM) is the most heterogeneous form of diabetes which is caused by complex interactions between genetic and environmental factors. Although genome-wide analysis has found several single nucleotide polymorphisms (SNPs) in association with T2DM, their documented role is ambiguous and very few studies have reported about the correlation of particular gene expression with T2DM. In this study, we aimed t...

Introduction: Thyroid surgery was initially considered as “horrid butchery” due to associated high morbidity and mortality, however with the advent of safe surgical techniques and improved understanding of thyroid physiology, thyroid surgery has become safer. Still there are certain intra-operative factors, as described in Difficulty Thyroidectomy Scale (DTS)which are thought to be associated with adverse outcome. However anatomical parameters also need to be address...

Background: Autoimmune destruction is the most common aetiology of primary adrenal insufficiency (PAI) in Europe and north America. In contrast, tuberculosis is a common cause of PAI in developing countries. More recently, adrenal histoplasmosis (AH) is being increasingly reported from IndiaAims: To study the aetiology, clinical presentation and mortality in adults with PAI who were diagnosed between 2006-2019 and to determine the changes in aetiology si...

Introduction: Maturity-onset diabetes of the young (MODY) 5 is caused by mutations in the TCF2 (HNF1B) gene encoding the transcription factor hepatocyte nuclear factor-1. However, in 60% ofthe patients with a phenotype suggesting MODY5, no pointmutation is detected in TCF2 gene. In some of those patients genomic rearrangements may be responsible for the phenotype.MODY5 or renal and diabetes syndrome (OMIM #137920) encompasses a wide cli...

We report a falsely elevated blood spot thyrotrophin (TSH) concentration caused by a TSH-IgG complex. A routine blood spot screen returned a whole blood TSH of 213 mU/l from a one week-old neonate using the Wallac DELFIA method. Measurement in serum confirmed elevated TSH (826 mU/l, Roche Elecsys assay) but free thyroxine (17.2 pmol/l) was normal. The baby’s mother was clinically euthyroid but also showed discordant high serum TSH (287 mU/l) with normal free thyroxine (13...