Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep26 | Adrenal and Cardiovascular Endocrinology | ECE2020

Genetic alterations and clinical features in 16 brazilian patients with pheochromocytomas and paragangliomas

Naliato Erika , Araujo Paula , Soares Paula , Lima Jorge , Lima Vinicius , Wo Julia , Sanchez Mirna , Carvalho Denise , Violante Alice

Introduction: Pheochromocytomasand paragangliomas are tumors derived from chromaffin cells which result from mutations of at least six different genes as autosomal dominant disorders.Aim: To evaluate the existence of correlations between genetic alterations and clinical data in 16 patients with pheochromocytomas and/or paragangliomas.Methods: From 2007 to 2009, 13 patients with pheochromocytoma [3 men, medium age 39 years (14&#8211...

ea0040l3 | Telomerase promoter mutations in cancer: beyond immortalization? | ESEBEC2016

Telomerase promoter mutations in cancer: beyond immortalization?

Soares Paula , Biology Group Cancer

Cell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomere maintenance due to the ‘alternative mechanism of telomere lengthening’ it was advanced that such immortalization could be due to telomerase reactivation, but the mechanisms underlying such reactivation remained elusive.Mutations in the coding region of telomerase gene are very rare in the cancer setting, despite being associated with...

ea0081p469 | Thyroid | ECE2022

Graves’ disease and polymorphisms in proinflammatory cytokines genes

Neves Celestino , Neves Joao Sergio , Goncalves Juliana , Soares Paula , Luis Medina Jose , Carvalho Davide

Background: Graves’ Disease (GD) is one of the most common organ specific autoimmune disorders, being characterized by an abnormal production of stimulating autoantibodies to the thyrotropin receptor (TSHR). Some studies demonstrated that genetic polymorphisms in certain cytokines, namely interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), are associated with a greater susceptibility of developing GD. Our aim was to evaluate ...

ea0081ep960 | Thyroid | ECE2022

Euthyroid sick syndrome as a prognostic marker in patients with SARS-CoV-2 infection

Estevens Joana , Santos Liliana R. , Nunes Daniel , Lemos Carlos , Soares Paula , Pais de Lacerda Antonio

After almost 3 years since SARS-CoV-2infection was detected for the first time, knowledge about its repercussions on the thyroid gland function in the course of acute illness or in the post-COVID-19 are still poorly understood. This gland may be particularly susceptible to SARS-CoV-2 as this coronavirus enters cells through ACE-2 receptors, which are largely expressed in the thyroid gland. Through an observational, longitudinal and retrospective study, we investigated the seru...

ea0084ps2-07-60 | Graves’ Disease 1 | ETA2022

Polymorphisms in proinflammatory cytokines’ genes and lipid profile in patients with graves’ disease

Neves Celestino , Sergio Neves Joao , Goncalves Juliana , Soares Paula , Delgado Luis , Carvalho Davide

Objective: Graves’ Disease (GD) is one of the most common autoimmune disorders. Some SNP in pro-inflammatory cytokines have already been linked to an increased susceptibility of developing GD. Thyroid hormones are crucial modulators of lipid metabolism. A pro-inflammatory state, may contribute several metabolic changes, including disturbances in lipid metabolism. Our aim was to evaluate if SNP in pro-inflammatory cytokines also contribute to disturbances of lipid profile ...

ea0092ps3-28-08 | Translational 2 | ETA2023

Understanding the putative role OF ACE2, TMPRSS2 and furin proteins on thyroid neoplastic transformation

Teresa Azevedo Maria , Macedo Sofia , Canberk Sule , Batista Rui , Soares Paula

Angiotensin-converting enzyme 2 (ACE2), Transmembrane serine protease 2 (TMPRSS2) and Furin were known to be key players for the SARS-CoV-2 infection. Thyroid gland was shown to be one of the relevant targets for SARS-CoV-2 infection allegedly due to the higher expression levels of these molecules in follicular cells. However, it remains to be fully determined the expression of ACE2, TMPRSS2 and Furin in normal follicular cell. In addition, the putative role of these molecules...

ea0084op-07-33 | Oral Session 7: Thyroid Cancer Basic | ETA2022

HüRthle cell tumors vs oncocytic variants of the follicular cell derived thyroid tumours: a comprehensive analysis based in transcriptome, proteome and cnv profiling

Canberk Sule , ferreira marta , Oliveira Carla , reis joana , barros rita , pereira luisa , osorio hugo , Rios Elisabete , Soares Paula , Maximo Valdemar

Objectives: Hürthle cell (oncocytic) lesions can be metaplastic or neoplastic events. The neoplastic entities -formerly, oncocytic variant of follicular tumours; Hürthle cell neoplasm (HCN) - include HC adenomas and HC carcinomas and have been recognized as a separate class of tumours by the WHO. The remaining of the thyroid tumours demonstrating “mitochondrion-rich cells” and oncocytic morphology are referred under the umbrella term of “oncocytic vari...

ea0049ep1357 | Thyroid (non-cancer) | ECE2017

Genetic variation in NFE2L2 and SEPS1S associated with increased risk of Hashimoto’s thyroiditis

Santos Liliana R , Duraes Cecila , Pestana Ana , Esteves Cesar , Neves Celestino , Carvalho David , Simoes Manuel Sobrinho , Soares Paula

Hashimoto’s thyroiditis (HT) is the most common chronic autoimmune thyroid disease, which is characterized by alteration of the thyroid function. HT is a multifactorial disorder and several candidate genetic loci have been identified as contributing to HT. The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. The relevance of selenoproteins in follicular thyroid cell physiology and in mole...

ea0073pep10.6 | Presented ePosters 10: Thyroid | ECE2021

Influence of pro-inflammatory cytokines polymorphisms on the interrelationship between Graves’ disease and diabetes

Celestino Neves , Neves Joao Sergio , Paula Soares , Delgado Luís , Luís Medina Luís , Carvalho Davide

BackgroundGraves’ Disease (GD) is characterized by production of stimulating autoantibodies to thyrotropin receptor resulting in hyperthyroidism. Hyperthyroidism is associated with insulin resistance, hyperglycemia and ketosis. Our aim was to evaluate if single nucleotide polymorphism (SNP) in pro-inflammatory cytokines contributes to dysglycemia in GD.MethodsWe evaluated 98 patients with Graves’ di...

ea0092ps1-08-06 | Translational 1 | ETA2023

Comparative cyto-histological genetic profile in a series of differentiated thyroid carcinomas

De Lurdes Godinho De Matos Maria , Pinto Mafalda , Alves Marta , Canberk Sule , Luisa Papoila Ana , Joao Bugalho Maria , Soares Paula

Introduction: Ultrasound-guided fine-needle aspiration cytology (US-FNAC), the gold standard method to distinguish benign from malignant thyroid nodules, is the most accurate, cost-effective and minimal invasive preoperative test, aiming to resolve patient management. However, up to 30% of US-FNACs are classified as indeterminate nodules, making difficult to avoid unnecessary surgeries. Molecular tests may contribute to refine the preoperative diagnosis of thyroid nodules....