Endocrine Abstracts

Introduction: Diagnosis of Cushing Syndrome (CS) is challenging due to its various non-specific symptoms, and multiple endogenous and exogenous causes. The incidence of endogenous CS is rare and estimated at 2 to 3 cases per million inhabitants per year in Europe (1). Primary bilateral macronodular adrenal hyperplasia (PBMAH) is an uncommon cause of endogenous ACTH-independent CS. It is a benign condition, characterized by the presence of bilateral macronodules (>1 cm), an...

Background: Adrenal insufficiency is a rare but potentially life threatening complication of the antiphospholipid antibody syndrome (APS). The adrenal gland is the most commonly involved endocrine organ with adrenal insufficiency reported in 0.4% of APS cases. Adrenal failure more often follows other thromboembolic manifestations of APS.Case report: We report a 25-year-old male with systemic lupus erythematosus (SLE) with antiphospholipid syndrome (tripl...

Pheochromocytoma is a rare catecholamine-secreting tumor with variable clinical manifestations. A possible cardiac presentation is acute left ventricular wall motion abnormality in the heart also known as the Takotsubo syndrome. Takotsubo stress cardiomyopathy was first described in 1990 in Japan and current knowledge remains limited. We report a case of pheochromocytoma-induced Takotsubo syndrome. A 43-year-old woman acutely developed nausea, severe chest pain, and dyspnoea d...

Background : The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of an unprecedented scale, with an ever-growing impact on healthcare systems. The clinical presentation of coronavirus disease 2019 (COVID-19) is diverse, ranging from asymptomatic illness to respiratory failure requiring admission to the intensive care unit (ICU). Risk factors for severe presentation include old age, male gender, underlying comorbidities such as metabolic syndr...

Objective: To compare the performances of the coronal contrast-enhanced T1-weighted (ceT1-w) and T2-weighted (T2-w) sequences, for the diagnosis of progression during the MRI follow-up of NFPAs.Materials and methods: 106 patients who had at least two MRIs for the follow-up of NFPA were retrospectively included. The largest diameter of the adenomas was measured on coronal ceT1-w and separately on T2-w sequences for all the MRIs of the follow-up, and by 2 ...

Introduction: Pituitary Neuroendocrine Tumor (PitNET) subtypes present functioning and silent variants but the silencing mechanisms are still unknown. One of the possible hypotheses could be a decrease in the expression of the specific adenohypophyseal hormone genes. The aim of the present study was to analyze the expression of adenohypophyseal hormone genes in a series of PitNETs, in order to evaluate differences between functioning and silent PitNET subtypes, taking into acc...

Thyroid Doppler ultrasound (TDUS) is highly used in the evaluation of thyroid nodules (TN). Malignant thyroid pathology has been more frequently associated with central vascularization of such nodules. There is controversy regarding the usefulness of the Resistance Index (RI) in the assessment of TN.Our aim was to analyze the utility of vascularization characteristics and RI at TDUS in the distinction of benign and malignant TN.Mat...

Aims: The aim of the present study was to evaluate the relative frequency of histological categories of thyroid malignant neoplasms. Another aim was to evaluate the TNM stage differentiated thyroid carcinoma (DTC) at the time of initial presentation in Valencia Community (Spain).Methods: Histopathology and TNM stage thyroid carcinomas diagnosed of thyroid carcinoma diagnosed between 1998 and 2005 in our endocrinology service, were recorded.The sample was...

Introduction: Vitamin D deficiency is associated with higher risk of severe COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (around 80.0% with plasma calcifediol <30 ng/ml) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown and the following winter in Northern Gran Canaria. There is an increasing awareness of this problem, both in family physicians and the general population, and t...

Introduction: We have recently reported that the use of cyproterone acetate (CPA) is associated with a highly significant increase of the risk of hypertension development after 5 years (adjusted hazard ratio 0.227, P< 0.001) in young transgender women. Due to the risks associated with the prolonged use of CPA (including the development of meningioma), the EMA presently recommends avoiding the use of doses > 10 mg CPA daily if possible. In fact, acceptable effi...