Searchable abstracts of presentations at key conferences in endocrinology

ea0056ep147 | Reproductive Endocrinology | ECE2018

From aneuploidy to eyploidy: a spontaneous, uncomplicated pregnancy in a patient with 45X0/47XXX mosaicism

Mavridi Artemis , Ntali Georgia , Theodora Marianna , Stamatelopoulos Kimon , Michala Lina

Turner syndrome (TS) is a chromosomal abnormality, due to a total or partial loss of one of the X chromosomes and is mostly characterized clinically by short stature and primary ovarian insufficiency. Spontaneous pregnancies in TS are rare (5%) and of relatively high risk, due to cardiovascular complications. Therefore, close medical monitoring is required. We report a case of a 21-year old woman with TS that had a full term uncomplicated pregnancy after spontaneous conception...

ea0032p207 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Subclinical atherosclerosis and cardiovascular risk in healthy, young menopausal women

Armeni Eleni , Stamatelopoulos Kimon , Georgiopoulos Georgios , Kouskouni Evangelia , Creatsa Maria , Alexandrou Andreas , Papamichael Christos , Lambrinoudaki Irene

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

ea0022p127 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Subjects homozygous for the BCL1 polymorphism of glucocorticoid receptor gene may have an increased risk for impaired endothelial function

Stamatelopoulos Kimon , Saltiki Katerina , Mantzou Emily , Voidonikola Paraskevi , Papamichael Christos , Alevizaki Maria

Objectives: Glucocorticoids may affect cardiovascular risk. Polymorphisms in the glucocorticoid receptor (GlucR) gene have been associated with increased risk for cardiovascular disease. We investigated whether the common Bcl1 polymorphism of the GlucR gene (associated with increased sensitivity to glucocorticoids) may be associated with early markers of atherosclerosis.Methods: Two hundred and fourteen middle aged apparently healthy subjects (age &#8230...

ea0020p355 | Diabetes and Cardiovascular | ECE2009

Endogenous estrogen levels are associated with endothelial function in males independently of lipid levels

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Introduction-aim: It has been suggested that estrogen may play an important role in the regulation of endothelium-dependent vasodilatation in both sexes. Especially in men, estradiol administration has been shown to improve endothelial function; however such reports are conflicting. The aim of our study was to examine the relation of endogenous sex hormone levels with markers of early atherosclerosis in a cohort of apparently healthy individuals.Methods:...

ea0020p455 | Obesity and Metabolism | ECE2009

Thyroid function tests, measures of adiposity and metabolic syndrome in apparently healthy euthyroid individuals

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Objective: Thyroid function tests (TFTs) have been associated with obesity; however associations with the type of adiposity have not been examined. Ultrasound (U/S) was used to assess regional adiposity in euthyroid individuals. Associations of thyroid function with obesity parameters and presence of the metabolic syndrome (MS) were investigated.Methods: Of 302 apparently healthy slightly overweight individuals (age 42.9±8.8, BMI 19.0–43.3, med...

ea0020p669 | Steroid Receptors | ECE2009

Androgen receptor gene CAG(n) repeat polymorphism and coronary artery disease (CAD) in women

Alevizaki Maria , Saltiki Katerina , Cimponeriu Adriana , Garofalaki Maria , Mantzou Emily , Stamatelopoulos Kimon

Objective: Androgen may be detrimental for vascular health in women. Sensitivity to androgen is influenced by the CAG repeat length of the androgen receptor (AR) gene. We investigated possible associations between the CAG repeat polymorphism with the severity of CAD in women undergoing coronary angiography.Methods: We examined 131 postmenopausal women (45–88 years). CAD severity was assessed by the number of coronary vessels with >50% stenosis. ...

ea0014p234 | (1) | ECE2007

Association of sex hormone-binding globulin (shbg) levels with measures of adiposity and metabolic profile in apparently healthy individuals

Saltiki Katerina , Voidonikola Paraskevi , Stamatelopoulos Kimon , Mantzou Emily , Chryssohoou Eleftheria , Papamichael Christos , Alevizaki Maria

Objective: The association of SHBG levels with obesity, hyperinsulinemia and metabolic abnormalities is well recognized in both men and women. Recent data suggest that SHBG levels are an important predictor of cardiovascular disease (CVD) risk. Several methods have been used for the measurement of adiposity including ultrasonography (U/S) which is a reliable and low-cost method. We used U/S to assess regional adiposity and investigated possible associations with SHBG levels.</...

ea0016oc6.5 | Metabolism and cardiovascular | ECE2008

Association of the SHBG gene promoter polymorphism with early markers of atherosclerosis in apparently healthy women

Saltiki Katerina , Voidonikola Paraskevi , Lazaros Leandros , Stamatelopoulos Kimon , Mantzou Emily , Georgiou Ioannis , Anastasiou Eleni , Papamichael Christos , Alevizaki Maria

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...

ea0016p39 | Adrenal | ECE2008

Impaired endothelial morphology and function in patients with subclinical Cushing's syndrome due to single adrenocortical adenomas

Androulakis Ioannis , Kollias Georgios , Markou Athina , Gouli Aggeliki , Anagnostou Tilemachos , Stamatelopoulos Kimon , Papamichael Christos , Piaditis Georgios , Kaltsas Gregory

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....

ea0077p239 | Reproductive Endocrinology | SFEBES2021

The rate of progression of atherosclerosis in menopause is associated with levels of circulating amyloid beta 1-40

Armeni Eleni , Delialis Dimitrios , Georgiopoulos Georgios , Tual-Chalot Simon , Vlachogiannis Nikolaos , Patras Raphael , Aivalioti Evmorfia , Augoulea Areti , Tsoltos Nikolaos , Soureti Anastasia , Stellos Konstantinos , Stamatelopoulos Kimon , Lambrinoudaki Irene

Background: Cardiovascular disease remains the leading cause of death worldwide, affecting both sexes. Awareness and prevention practices aiming to control cardiovascular risk in women remain inadequate. On the other hand, circulating amyloid β 1-40 (Aβ1-40) is a proatherogenic peptide, closely linked with the process of aging. We aimed to evaluate the possible association between the progression of atherosclerosis in postmenopausal women and the role of Aβ1-40 ...